A Hundred Years of the Chemosensory Synapse: A Tribute to Fernando de Castro [0.03%]
纪念费尔南多·德卡斯特罗教授诞辰一百周年——化学感受突触的百年研究进展
Fernando de Castro,José López-Barneo
Fernando de Castro
The Absence of Collagen VI Reduces Systolic Function but Paradoxically Increases Ca2+ Release in the Rat Heart [0.03%]
胶原蛋白VI缺失降低心室收缩功能但增加大鼠心脏钙离子释放
A Krstic,H Moammer,S Hassan et al.
A Krstic et al.
Aim: Collagen VI has recently been strongly linked to poor outcomes in heart failure through increased endotrophin, a collagen VI-derived signaling molecule linked to fibrotic remodeling in cardiovascular disease. The mut...
DDR1 Regulates Femoral Arterial Calcification in Lower-Extremity Artery Disease Through NF-Kappa B Activation [0.03%]
通过NF-κB激活调节股动脉钙化以治疗下肢动脉疾病中的DDR1
Manovriti Thakur,Thibaut Quillard,Nico Angliker et al.
Manovriti Thakur et al.
Aim: Lower-extremity arterial disease (LEAD) is a manifestation of atherosclerotic cardiovascular disease, affecting 230 million people worldwide with increasing prevalence. Medial arterial calcification (MAC) is common i...
Arild Njå,Terje Lømo
Arild Njå
Aim: We have previously described an important role of skeletal muscle tone in body temperature regulation, muscle tone defined as the tonic motor unit activity recorded between movements. Here, we study muscle tone in an...
Succinate Modulation as a Biochemical Correlate of Metabolic and Neurobehavioral Changes Associated With Intermittent Fasting in Obesity [0.03%]
肥胖症间歇性禁食相关的代谢和神经行为变化的生化相关因素——琥珀酸调节作用
Andrea Tognozzi,Fabrizia Carli,Sherif Abdelkarim et al.
Andrea Tognozzi et al.
Aim: Obesity significantly impacts the central nervous system (CNS), increasing the risks of neuropsychiatric disorders and dementia. Intermittent fasting (IF) shows promise for improving peripheral and CNS health, but it...
Upregulated Calcium Sensing Receptor Mediates Pulmonary Venous Remodeling in Pulmonary Hypertension [0.03%]
上调的钙敏感受体介导肺高血压中的肺静脉重构
Qiudi Mo,Xing Wen,Luyao Wang et al.
Qiudi Mo et al.
Aim: The mechanism of pulmonary venous remodeling (PVR) remains unclear. We tested the role of the calcium sensing receptor (CaSR) in PVR in pulmonary hypertension (PH). ...
Effect of Weight-Neutral Treatment With Semaglutide or Tirzepatide on β-Cell Identity in db/db Mice [0.03%]
利拉鲁肽或 tirzepatide 体重中性治疗对 db/db 小鼠β细胞身份的影响
Zhaobin Deng,Dongxu Zheng,Jinsook Son et al.
Zhaobin Deng et al.
Aim: Insulin resistance and pancreatic β-cell failure are key characteristics of type 2 diabetes (T2D). Impaired β-cell function is associated with loss of β-cell identity, resulting in β-cell dedifferentiation or tra...
Suprachiasmatic Nuclei Possess Glucocorticoid Receptors That Activate Downstream Signaling Pathways but Do Not Entrain Their Circadian Clock [0.03%]
视上核具糖皮质激素受体可激活下游信号通路但不能为其昼夜钟同步化提供线索
Martin Sládek,Vendula Lužná,Pavel Houdek et al.
Martin Sládek et al.
Aim: The circadian clock in the suprachiasmatic nuclei of the hypothalamus (SCN) is resistant to glucocorticoids (GC) in adults but responds to dexamethasone (DEX) during the fetal stage. Previously, this resistance of th...
Acute Normobaric Hypoxia Reveals Blunted Chemoreflex and Autonomic Dysfunction in Asymptomatic Post-COVID-19 Patients [0.03%]
急性常压低氧条件下无症状新冠后遗症患者化学感受器反射和自主神经功能减退
Elissa Silva de Farias Mello,André Luiz Musmanno Branco Oliveira,Pedro Paulo da Silva Soares et al.
Elissa Silva de Farias Mello et al.
Rudolf Schubert
Rudolf Schubert