Fentanyl Disrupts Vagal Control of Airway Tone to Induce Transient Obstruction [0.03%]
芬太尼通过干扰迷走神经控制气道张力来诱导短暂性气道梗阻
Riley R Parks,Marissa J Andersen,Mackenna L Hatfield et al.
Riley R Parks et al.
Aim: Opioid-induced respiratory depression (OIRD) is the primary cause of death in opioid overdose, resulting from both suppressed respiratory rhythm and increased airway and thoracic rigidity that compromise ventilation ...
Electrical Remodeling of Pressure Overloaded Rat Heart Is Attenuated if Imposed During Proliferative Cardiac Growth [0.03%]
增生性心脏生长时施加的压力过载大鼠心脏电重构减弱
Eva Nekvindova,Jaroslav Hrdlicka,Almos Boros et al.
Eva Nekvindova et al.
Aim: Left ventricular pressure overload (LVPO) in adults is associated with adverse electrical remodeling, characterized by reduced conduction velocity (CV). However, the progression of LVPO differs when imposed during th...
Dietary Nitrate Prevents Cardiac Dysfunction in HFrEF by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation [0.03%]
膳食硝酸盐通过改善血流动力学、减轻重塑和缓解炎症来预防HFrEF心脏功能障碍
Miho Shimari,Gaia Picozzi,Ariela Boeder et al.
Miho Shimari et al.
Aims: Impaired cardiac function, reduced nitric oxide (NO) bioavailability, and inflammation are key contributors to the pathogenesis and progression of heart failure with reduced ejection fraction (HFrEF). This study aim...
Transduction Mechanisms for Cold Temperature in Mouse Trigeminal and Vagal Ganglion Neurons Innervating Different Peripheral Organs [0.03%]
小鼠三叉神经和迷走神经中支配不同外周器官的感觉神经元的冷信号转导机制
Katharina Gers-Barlag,Ana Gómez Del Campo,Pablo Hernández-Ortego et al.
Katharina Gers-Barlag et al.
Aim: To elucidate the molecular mechanism of cold sensing by visceral sensory endings, a side-by-side characterization of cold-sensitive (CS) neurons in adult mouse trigeminal (TG) and vagal ganglia (VG) was performed. ...
MiR-126-5p Derived From Bone Marrow Mesenchymal Stem Cell Exosomes Promotes Skeletal Muscle Regeneration by Regulating FBXO32/MyoD Signaling [0.03%]
骨髓间充质干细胞外泌体来源的miR-126-5p通过调节FBXO32/MyoD信号促进骨骼肌再生
Yi Yan,Minxing Zheng,Xuanjing Wang et al.
Yi Yan et al.
Aim: In the process of muscle growth and repair, microRNAs (miRNAs) serve as a critical factor in spatiotemporal regulation. Nevertheless, the molecular regulatory mechanisms underlying muscle regeneration remain largely ...
The Impact of Preeclampsia and Gestational Diabetes on Future Maternal Cardiometabolic Health [0.03%]
子痫前期和妊娠糖尿病对母亲未来心血管代谢健康的影响
Alice M Barrell,Amanda N Sferruzzi-Perri
Alice M Barrell
Introduction: Pregnancy is a time of significant maternal physiological change to meet the metabolic demands of the feto-placental unit. In cases of pregnancy complications, mal-adaptive physiological responses may occur,...
Spatiotemporal Differences of GABAergic Polarization and Shunting During Dendritic Integration [0.03%]
树突整合过程中GABA能极化和分流的时空差异性
Yulia Dembitskaya,Artem Kirsanov,Yu-Wei Wu et al.
Yulia Dembitskaya et al.
Aim: In the adult brain, GABA exerts either depolarizing or hyperpolarizing effects on neuronal membranes, depending on neuron type, subcellular location, and neuronal activity. Depolarizing GABA typically inhibits neuron...
Does Calcium Supplementation Negate Erythropoiesis With Endurance Training? [0.03%]
钙补充会影响耐力训练引起的红细胞增多症吗？
Meihan Guo,David Montero
Meihan Guo
Natural Mutation in Naked Mole-Rat UCP1 Refutes Importance of the Histidine Pair Motif for Proton Conductance and Thermogenesis [0.03%]
无毛 mole-rat UCP1 的天然突变否定了 His 对子基序对质子传导和产热的重要性
Michael J Gaudry,Amanda Bundgaard,Maria Kutschke et al.
Michael J Gaudry et al.
Aim: Uncoupling protein 1 (UCP1) is the crucial protein for non-shivering thermogenesis in placental mammals, but the molecular mechanism of thermogenic proton transport is still unknown. Its histidine pair motif (H145 an...