The Calcium-Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses [0.03%]
钙结合蛋白S100A10（p11）通过调节兴奋性突触的囊泡动态变化对正常运动性能发挥重要作用
Esther Vilches-Herrando,Guillermo Rodríguez-Bey,Rosendo G Hernández et al.
Esther Vilches-Herrando et al.
Aim: Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. ...
Dominique Sage-Ciocca,Etienne Challet
Dominique Sage-Ciocca
Acyl-CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice [0.03%]
乙酰辅酶a结合蛋白在白色和棕色脂肪组织中可有可无，对小鼠全身能量代谢的影响较小
M F Nørremark,R Petersen,P M M Ruppert et al.
M F Nørremark et al.
Aim: Acyl-CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long-chain acyl-CoAs. We generated an adipocyte-wide ACBP knockout mouse and a brown adipose tiss...
Human Skeletal Muscle Mitochondria Responses to Weight Loss Induced by Bariatric Surgery or Lifestyle Intervention [0.03%]
代谢手术或生活方式干预引起的减肥对人类骨骼肌线粒体的影响
Birgitta W van der Kolk,Sini Heinonen,James W White et al.
Birgitta W van der Kolk et al.
Aim: We investigated how weight loss induced by bariatric surgery or lifestyle intervention affects skeletal muscle mitochondrial metabolism. Methods: ...
Randomized Controlled Trial
Acta physiologica (Oxford, England). 2026 Feb;242(2):e70150. DOI:10.1111/apha.70150 2026
Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium [0.03%]
人类肠上皮细胞中SLC26A3和CFTR在表面pH调节和HCO3-分泌中的不同作用
Mahdi Amiri,Azam Salari,Ursula Seidler
Mahdi Amiri
Background and aims: Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosi...
Do Andean Aymara High-Altitude-Enriched Genetic Variants Protect Europeans Against Acute Mountain Sickness? [0.03%]
安第斯阿亚马人高海拔富集的遗传变异能够保护欧洲人体内急性高原病吗？
Josef T Prchal,Martin Burtscher,Soo Jin Kim et al.
Josef T Prchal et al.
Oral Acid Load Lowers Bacterial Burden and Elevates Urinary Proinflammatory Response in a Mouse Model of Urinary Tract Infection [0.03%]
口服酸性物质可降低泌尿系统感染小鼠模型中的细菌数量并升高尿液中促炎因子的水平
Aimi D K Hamilton,Johanna Hornhaver,Laura V Sparsoe et al.
Aimi D K Hamilton et al.
Aim: Urinary tract infections (UTIs) are common and frequently caused by uropathogenic Escherichia coli (UPEC). Whether urinary pH has any influence on the development and progression of UTIs is still widely debated. In t...
Chemogenetic Restoration of the "Excitation-Inhibition" Imbalance in the Medial Prefrontal Cortex Ameliorates Schizophrenia-Like Sensory Gating Deficits [0.03%]
化学遗传学恢复内侧前额叶皮质的“兴奋-抑制”不平衡可改善精神分裂症样的感觉门控缺陷
Xiaoyu Chen,Lichun He,Qiuxia Zhang et al.
Xiaoyu Chen et al.
Aim: Sensory gating is a neurological mechanism that filters out irrelevant sensory input, protecting cognitive processing from sensory overload. Patients with schizophrenia usually lack sensory gating, which severely aff...
Untethered and Triggered: Collagen VI Loss at the Nexus of Force, Fibrosis, and Arrhythmia [0.03%]
未附着与触发：VI型胶原蛋白损失在力、纤维化和心律失常的交汇点上的作用
Robert G Gourdie
Robert G Gourdie
Ependymal Yes-Associated Protein Promotes the Neural Regeneration Through Enhancing the Ependymal Cell-Derived Perilesional Glial Borders in Mice After Spinal Cord Injury [0.03%]
少突胶质前体细胞起源的脑膜母细胞瘤的克隆演化
Jiashu Lian,Xiaowu Lin,Jiali Shi et al.
Jiashu Lian et al.
Objectives: Ependymal cell-derived perilesional glial borders may play a beneficial role in neural regeneration after spinal cord injury (SCI). Yes-associated protein (YAP), a key transcriptional cofactor, is involved in ...