Yu-Xiang Wang,Qi Chen
Yu-Xiang Wang
Ketone Monoester Increases Skeletal Muscle Power and Energy Turnover in Older but Not Young Men Without Affecting Metabolic Economy: A Controlled, Double Blind, Cross-Over Trial [0.03%]
羟基酯增加老年人而非年轻人的骨骼肌能量周转但不影响代谢效率：一项控制的双盲交叉试验
Ole Emil Andersen,Ryan Godsk Larsen,Niels Møller et al.
Ole Emil Andersen et al.
Aim: Ketosis may represent a therapeutic target for age-related impairments in skeletal muscle function. This study investigated acute effects of ketosis on metabolic economy, mitochondrial function, and contractile param...
Randomized Controlled Trial
Acta physiologica (Oxford, England). 2026 Mar;242(3):e70161. DOI:10.1111/apha.70161 2026
WDR72 Is Required for Urinary Acidification and Normal H+-ATPase Activity in Intercalated Cells in Mice [0.03%]
WDR72对于小鼠尿液酸化及正常H+-ATP酶在闰细胞中的活性是必需的
Hannah Auwerx,Moana Busch-Dohr,Xiaoxu Li et al.
Hannah Auwerx et al.
Aim: Biallelic inactivating WDR72 variants are linked to distal renal tubular acidosis (dRTA), nephrocalcinosis, and amelogenesis imperfecta. The kidney shows high WDR72 expression; its precise localization and function r...
Glucagon-Like Peptide-1 Receptor Agonists in Obesity-Induced Respiratory Pathophysiology [0.03%]
胰高糖素样肽-1受体激动剂在肥胖诱导的呼吸病理生理学中的作用
Melanie Alexis Ruiz,Thales Henrique do Carmo Furquim,Dashdulam Davaanyam et al.
Melanie Alexis Ruiz et al.
ClC-2 Contributes to Hypotonicity-Induced Adrenal Aldosterone Secretion [0.03%]
ClC-2参与低张力诱导的肾上腺醛固酮分泌
Marina Volkert,Hoang An Dinh,Ute I Scholl et al.
Marina Volkert et al.
Aim: The zona glomerulosa (ZG) of the adrenal cortex regulates blood pressure and electrolyte homeostasis through aldosterone production. In ZG cells, potassium and angiotensin II (Ang II) trigger calcium oscillations tha...
Functional Training Mitigates Reduced Circulating Indole-3-Lactate Levels in Persons With Relapsing-Remitting Multiple Sclerosis [0.03%]
功能训练缓解复发性多发性硬化症患者循环色氨酸水平降低的效果
Tiffany Wences Chirino,Frederike Adammek,Sergen Belen et al.
Tiffany Wences Chirino et al.
Aim: Indoles are tryptophan (Trp)-derived metabolites that are produced by the gut microbiota and may influence the gut-microbiota-brain axis in multiple sclerosis (MS). Indole-3-lactate (ILA) is reduced in persons with M...
Randomized Controlled Trial
Acta physiologica (Oxford, England). 2026 Mar;242(3):e70166. DOI:10.1111/apha.70166 2026
The Secondary Motor Cortex Encodes Aversive Signals and Exerts an Inhibitory Control of Motor Sequence Learning in Mice [0.03%]
小鼠 secondary motor cortex 区域编码厌恶信号并施加运动序列学习的抑制控制作用
Xinran Pan,Yan Li,Qionghui Cai et al.
Xinran Pan et al.
Aim: The secondary motor cortex (M2) is engaged in behavioral planning, movement preparation, and the execution of complex motor sequences in a specific order. However, the nature of neuronal signals encoded by M2 neurons...
Non-Hebbian Long-Term Depression at VIP Interneuron Inputs Selectively Tunes Inhibition in Disinhibitory Circuits of Mouse Hippocampus [0.03%]
抑制性神经元输入中的非赫布式长期抑制调节小鼠海马区的去抑制环路
Jadwiga Jabłońska,Grzegorz Wiera,Jerzy W Mozrzymas
Jadwiga Jabłońska
Aim: Control of synaptic inhibition at the network level is essential for neuronal computation; however, the mechanism by which inhibitory I → I synapses between interneurons adjust their strength remains unclear. Here, ...
Kristian Gundersen,Jo C Bruusgaard,Einar Eftestøl
Kristian Gundersen
Changes in muscle mass and force are mainly related to changes in fiber size. In eukaryotes, DNA-content and cell size are generally correlated, suggesting the existence of a DNA-template limitation. This might be particularly important in ...
Activation of TGR5 Alleviates Renal Fibrosis by Promoting NEDD4L-Mediated p-Smad2/3 Ubiquitination [0.03%]
TGR5活化通过促进NEDD4L介导的p-Smad2/3泛素化来缓解肾纤维化
Meng Li,Luosha Long,Xiaoduo Zhao et al.
Meng Li et al.
Aim: Renal fibrosis is a major contributor to chronic kidney disease (CKD) progression and eventual organ failure. G protein-coupled bile acid receptor 1 (TGR5) was previously shown to have beneficial effects on kidney di...