Vitamin K preserves gamma-glutamyl carboxylase activity against carbamylations in uremia: Implications for vascular calcification and adjunct therapies [0.03%]
维生素K通过对抗尿毒症中的卡宾衍生物保护γ-谷氨酰羧化酶的活性：对血管钙化及辅助治疗的意义
Nadine Kaesler,Suresh Kaushik,Janina Frisch et al.
Nadine Kaesler et al.
Aim: Vascular calcification contributes to morbidity and mortality in aging and is accelerated in diabetes and in chronic kidney disease. Matrix Gla Protein is a potent inhibitor of vascular calcification, which is activa...
Cav3.1 T-Type Calcium Channel Acts as a Gateway for GABAergic Excitation in the Medial Prefrontal Cortex That Leads to Chronic Psychological Stress Responses in Mice [0.03%]
前额皮质中的T型Ca2+通道 Cav3.1作为GABA能兴奋信号传导的门控，介导小鼠慢性心理应激反应
Yasushi Yabuki,Karin Hori,Zizhen Zhang et al.
Yasushi Yabuki et al.
Aim: The molecular mechanisms of chronic stress-induced psychiatric disorders, including depression, remain unknown. The current study aimed to assess the role of Cav3.1 T-type calcium channels as a gateway for the chroni...
Glucose absorption by isolated, vascularly perfused rat intestine: A significant paracellular contribution augmented by SGLT1 inhibition [0.03%]
葡萄糖通过孤立的血管灌流大鼠小肠上皮吸收：SGLT1抑制促进其经旁细胞途径吸收
Cecilie Bæch-Laursen,Rune Kuhre Ehrenreich,Ida Marie Modvig et al.
Cecilie Bæch-Laursen et al.
Aim: Intestinal glucose transport involves SGLT1 in the apical membrane of enterocytes and GLUT2 in the basolateral membrane. In vivo studies have shown that absorption rates appear to exceed the theoretical capacity of t...
Pharmaceutical prokinetic and surgical interventions have opposing effects on gastroduodenal electromechanical coupling [0.03%]
药物促动力和手术干预措施对胃十二指肠电机械偶联产生相反的影响
Sam Simmonds,Tim H-H Wang,Ashton Matthee et al.
Sam Simmonds et al.
Improper gastric emptying is implicated in several gastrointestinal disorders and may result from disrupted electromechanical coupling of the gastroduodenal junction (GDJ). Rhythmic "slow waves" and myogenic "spikes" are bioelectrical mecha...
16/8 intermittent fasting in mice protects from diet-induced obesity by increasing leptin sensitivity and postprandial thermogenesis [0.03%]
间歇性禁食通过提高饮食诱导的体温和瘦素敏感性来防止肥胖
Adriano Cleis Arruda,Raisa Brito Santos,Leandro Ceotto Freitas-Lima et al.
Adriano Cleis Arruda et al.
Aims: To evaluate the molecular mechanisms involved in intermittent fasting 16/8 (16/8 IF), a widespread dietary practice adopted worldwide that consists of 16 h of fasting and 8 h of feeding. ...
Tobias Wang
Tobias Wang
Deficiency of the Synaptic Adhesion Protein Leucine-Rich Repeat Transmembrane Protein 4 Like 1 Affects Anxiety and Aggression in Zebrafish [0.03%]
粘附蛋白LRRTM1同系物的缺乏影响斑马鱼的焦虑和攻击行为
Eva Tatzl,Giulia Petracco,Isabella Faimann et al.
Eva Tatzl et al.
Aim: Leucine-rich repeat transmembrane proteins (LRRTMs) are synaptic adhesion proteins that regulate synapse development and function. They interact transsynaptically with presynaptic binding partners to promote presynap...
Exercise training restores longevity-associated tryptophan metabolite 3-hydroxyanthranilic acid levels in middle-aged adults [0.03%]
运动训练可恢复中年成人与长寿相关色氨酸代谢物3-羟基抗坏血酸水平
Niklas Joisten,Marcel Reuter,Friederike Rosenberger et al.
Niklas Joisten et al.
Aim: Recent pre-clinical evidence suggests that the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) and the related enzyme activity along the kynurenine metabolic pathway (KP) are associated with lifespan extensio...
Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy [0.03%]
乳酸通过组合使用静脉收缩，动脉舒张和正性肌力作用来协调代谢的血流动力学改变
Casper Homilius,Jacob M Seefeldt,Jakob Hansen et al.
Casper Homilius et al.
Aim: H+ facilitates metabolic blood flow regulation while negatively impacting cardiac contractility. Cardiovascular consequences of conjugate bases accumulating alongside H+ remain unclear. Here, we evaluate the cardiova...