Lack of Synaptic Adhesion Proteins Makes Zebrafish More Anxious and Less Aggressive [0.03%]
粘附蛋白缺失使斑马鱼更加焦虑且更具攻击性
Maja R Adel,Florian Freudenberg
Maja R Adel
Secretagogin, Driven by Neuronal Activity, Transiently Regulates Exocytosis During Development [0.03%]
分泌活动驱动的secretagogin在发育过程中瞬时调节胞外转运
Robert Zorec,Alexei Verkhratsky
Robert Zorec
Specialized Pro-Resolving Mediators as Emerging Players in Cardioprotection: From Inflammation Resolution to Therapeutic Potential [0.03%]
炎症消退介质在心脏保护中的新兴作用：从促进炎症消退至治疗潜力
Anna De Bartolo,Naomi Romeo,Tommaso Angelone et al.
Anna De Bartolo et al.
Aim: Timely myocardial reperfusion is essential for restoring blood flow to post-ischemic tissue, thereby reducing cardiac injury and limiting infarct size. However, this process can paradoxically result in additional, ir...
Neutrophil Function in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis [0.03%]
慢性肾脏病患者中性粒细胞功能的系统评价和meta分析
Jane Sophie Lauxen,Sonja Vondenhoff,Carolina Victoria Cruz Junho et al.
Jane Sophie Lauxen et al.
Background: Patients with chronic kidney disease (CKD) are at increased cardiovascular risk. Since neutrophils play a central role in atherosclerosis and cardiovascular disease, this study analyzed neutrophil function in ...
The Ancient Drug Salicylate Indirectly Targets Fructose-1,6-Bisphosphatase to Suppress Liver Glucose Production in Diet-Induced Obese Mice [0.03%]
古老的药物水杨酸通过间接靶向果糖-1，6-二磷酸酶来抑制肥胖小鼠的肝脏葡萄糖生成
Raid B Nisr,Abdelmadjid Atrih,Erika J Gutierrez Lara et al.
Raid B Nisr et al.
Aims: The benefit of salicylate in the treatment of diabetes has been recognized for over a century; however, challenging side effects have prevented widespread use. A better understanding of the relevant enzyme targets m...
Comparison of Phasic Store-Operated Calcium Entry in Rat Slow- and Fast-Twitch Muscle Fibers [0.03%]
大鼠慢缩肌纤维和快缩肌纤维阶段性储钙释放操作性钙内流的比较研究
Elena Lilliu,Rocky Choi,Karlheinz Hilber et al.
Elena Lilliu et al.
Aim: This study investigates the activation and regulation of phasic store-operated calcium entry (pSOCE) in fast- and slow-twitch skeletal muscle fibers. Specifically, we aimed to enhance the sensitivity of pSOCE detecti...
Comparative Study
Acta physiologica (Oxford, England). 2025 Jun;241(6):e70059. DOI:10.1111/apha.70059 2025
Chronic High-Fat Diet Consumption Followed by Lipopolysaccharide Challenge Induces Persistent and Long-Lasting Microglial Priming, Mediates Synaptic Elimination via Complement C1q, and Leads to Behavioral Abnormalities in Male Wistar Rats [0.03%]
长期高脂饮食后脂多糖攻击诱导雄性Wistar大鼠小胶质细胞表型持久改变并介导突触消除及行为异常
Titikorn Chunchai,Hiranya Pintana,Chanon Kunasol et al.
Titikorn Chunchai et al.
Aim: Microglia exhibit innate immune memory, altering their responses to subsequent challenges. Consumption of high-fat diet (HFD) triggers innate immune responses, but the characteristics of HFD-induced microglial primin...
Martin Jastroch,Michaela Keuper
Martin Jastroch