Lipocalin-2 Restores Soluble Guanylyl Cyclase-Dependent Dilation of the Afferent Arteriole After Renal Transplantation or Ex Vivo Hypoxia/Reoxygenation in Mice [0.03%]
脂联素-2可恢复肾移植或体外缺血再灌注后小鼠系膜动脉一氧化氮介导的舒张反应
Liang Zhao,Minze Xu,Anna Maria Pfefferkorn et al.
Liang Zhao et al.
Aim: Dilatory microvascular function is impaired in ischemia/reperfusion injury in the kidney. Nitric oxide independent activators of soluble guanylyl cyclase (sGC) provide renal protection by dilating microvessels and pr...
Reversal of Diabesity Through Modulating Sympathetic Inputs to Adipose Tissue Following Carotid Body Resection [0.03%]
通过切断颈动脉体交感神经向脂肪组织的输入治疗糖尿病肥胖症
Bernardete F Melo,Joana F Sacramento,Julien Lavergne et al.
Bernardete F Melo et al.
Background and aims: The development of innovative strategies to treat diabesity and its comorbidities is of major societal importance. The carotid bodies (CB), classically defined as O2 sensors, are also metabolic sensor...
Effects of Dietary BCAAs Intake on the Blood Pressure in Dahl Salt-Sensitive Rats [0.03%]
饮食BCCAs摄入对Dahl盐敏感大鼠血压的影响
Meng Chen,Li Zeng,Xiangbo Chen et al.
Meng Chen et al.
Aim: Circulating branched-chain amino acids (BCAAs) have been widely found to be associated with the risk of hypertension, but mechanisms remain unclear. In this study, we hypothesized that BCAAs could alleviate the devel...
Cardiolipin Remodeling in Cardiovascular Diseases: Implication for Mitochondrial Dysfunction [0.03%]
心脏疾病中的心磷脂重塑：线粒体功能障碍的潜在原因
Huijie Zhang,Fengzhi Yu,Zhenjun Tian et al.
Huijie Zhang et al.
Aim: Mitochondrial dysfunction is pivotal in both the development and progression of cardiovascular diseases (CVDs), though its exact mechanisms remain unclear. Cardiolipin (CL), a key mitochondrial phospholipid, is invol...
Fatty Acid Taste Quality Information via GPR40 and CD36 in the Posterior Tongue of Mice [0.03%]
小鼠舌后部脂肪酸味质信息的GPR40和CD36受体感知
Yumiko Nagai,Kenichi Tokita,Keiko Yasumatsu
Yumiko Nagai
Aim: Taste cells expressing GPR120 and connected chorda tympani nerve (CT) fibers are necessary for obtaining specific information on long-chain fatty acids (FA) in mice. However, the functions of GPR40, GPR120, and CD36 ...
Molecular Dynamics Simulations of a Putative Novel Mechanism for UCP1-Assisted FA Anion Transport [0.03%]
UCP1辅助FA阴离子运输的拟议新型机制的分子动力学模拟
Sanja Vojvodić,Giorgia Roticiani,Mario Vazdar et al.
Sanja Vojvodić et al.
Background: Mitochondrial energy can be stored as ATP or released as heat by uncoupling protein 1 (UCP1) during non-shivering thermogenesis in brown adipose tissue. UCP1, located in the inner mitochondrial membrane, reduc...
Aquaporin-4-Mediated Water Permeability Rescues Aquaporin-3 Deficiency Caused Nephrogenic Diabetes Insipidus [0.03%]
Aquaporin-4介导的水平衡可校正Aquaporin-3缺陷引起的尿崩症
Yi Ying,Zhiwei Qiu,Jihan Liu et al.
Yi Ying et al.
Aim: The aim of this study was to determine whether water or solute transport plays a critical role in AQP3-mediated urine concentrating ability, using AQP3 knockout (AQP3-KO) mice and a novel mouse model in which the AQP...
Multi-Wearable Approach for Monitoring Diurnal Light Exposure and Body Rhythms in Nightshift Workers [0.03%]
用于监测夜班工人昼夜光照暴露和机体节律的多可穿戴设备方法
Steffen L Hartmeyer,Nicholas E Phillips,Friedrich C Jassil et al.
Steffen L Hartmeyer et al.
Aim: As our understanding of light's impact on human health grows, studies examining light exposure and related health outcomes in everyday settings are increasingly important, particularly in high-risk groups like nights...
Observational Study
Acta physiologica (Oxford, England). 2025 Jul;241(7):e70069. DOI:10.1111/apha.70069 2025
Revisiting Concepts of Thermal Physiology: Understanding Feedback and Feedforward Control, and Local Temperature Regulation [0.03%]
重温热生理学概念：理解反馈和前馈控制以及局部温度调节
Duncan Mitchell,Shane K Maloney,Edward P Snelling et al.
Duncan Mitchell et al.
Most experts agree that the dominant mechanism through which body temperature is regulated, under a thermal challenge, environmental or metabolic, is negative feedback control. However, some consider negative feedback to be too sluggish to ...
Branched-Chain Amino Acids and Di-Alanine Supplementation Attenuates Muscle Atrophy in a Murine Model of Cancer Cachexia [0.03%]
支链氨基酸和二 Ala 补充剂缓解了癌性恶病质小鼠模型的肌肉萎缩现象
Mayra Colardo,Noemi Martella,Michela Varone et al.
Mayra Colardo et al.
Aim: Cancer cachexia is a severe metabolic disorder leading to skeletal muscle atrophy. Muscle wasting is a major clinical problem in cachectic patients, as it limits the efficacy of chemotherapeutic treatments and worsen...