The thoughtful bowel [0.03%]
深思熟虑的肠道
Michael D Gershon
Michael D Gershon
GLUT12-A promising new target for the treatment of insulin resistance in obesity and type 2 diabetes [0.03%]
GLUT12──肥胖和2型糖尿病治疗的新靶点绝缘抵抗力
Mariana Astiz,Henrik Oster
Mariana Astiz
Adult vascular dysfunction in foetal growth-restricted guinea-pigs is associated with a neonate-adult switching in Nos3 DNA methylation [0.03%]
胎儿生长受限的 Guinea Pig 成年后血管功能障碍与Nos3 DNA甲基化的新生儿-成年转换有关
Bernardo J Krause,Estefanía Peñaloza,Alejandro Candia et al.
Bernardo J Krause et al.
Aim: Foetal growth restriction (FGR) is associated with endothelial dysfunction and cardiovascular diseases in adult subjects. Early vascular remodelling and epigenetic changes occurring on key endothelial genes might pre...
Angiotensin II inhibits P-glycoprotein in intestinal epithelial cells [0.03%]
血管紧张素II抑制肠上皮细胞P-糖蛋白的功能
Anoop Kumar,Shubha Priyamvada,Vikas Soni et al.
Anoop Kumar et al.
Aim: P-glycoprotein (Pgp/MDR1) plays a major role in intestinal homeostasis. Decrease in Pgp function and expression has been implicated in the pathogenesis of IBD. However, inhibitory mechanisms involved in the decrease ...
Natalia Strugala,Pontus B Persson
Natalia Strugala
AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting [0.03%]
AKAP12缺陷通过抑制VEGF诱导的内皮细胞迁移和出芽损害血管生成
Peter M Benz,Yindi Ding,Heike Stingl et al.
Peter M Benz et al.
Aim: Protein kinase (PK) A anchoring protein (AKAP) 12 is a scaffolding protein that anchors PKA to compartmentalize cyclic AMP signalling. This study assessed the consequences of the downregulation or deletion of AKAP12 ...
Driton Vela
Driton Vela
Highly active cardiomyocytes need iron for their metabolic activity. In physiological conditions, iron turnover is a delicate process which is dependent on global iron supply and local autonomous regulatory mechanisms. Though less is known ...
miR-29a promotes pathological cardiac hypertrophy by targeting the PTEN/AKT/mTOR signalling pathway and suppressing autophagy [0.03%]
microRNA-29a通过靶向PTEN/AKT/mTOR信号通路并抑制自噬促进病理性心脏肥大
Jia-Yu Shi,Chu Chen,Xuan Xu et al.
Jia-Yu Shi et al.
Aim: Although miR-29 has emerged as a crucial non-coding RNA in the regulation of pathological cardiac hypertrophy, further exploration of its specific mechanisms is necessary to resolve controversy about its major role i...
Gunnar Flemström's legacy in intestinal bicarbonate secretion-A homage to Gunnar Flemström and his work in intestinal bicarbonate secretion [0.03%]
贡纳·弗莱姆斯特罗姆对肠碳酸氢盐分泌的贡献——致贡纳·弗莱姆斯特罗姆及其在肠碳酸氢盐分泌研究中的成就
Ursula Seidler,Olof Nylander,Markus Sjoblom et al.
Ursula Seidler et al.