The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears (Ursus arctos) [0.03%]
斯堪的纳维亚棕熊（Ursus arctos）冬眠期间低代谢状态下肌肉线粒体装置的保持机制
Audrey Bergouignan,John Noone,Charlotte Brun et al.
Audrey Bergouignan et al.
Aim: Unlike humans, brown bears (Ursus arctos) uniquely preserve skeletal muscle mass and function during months of hibernation despite prolonged fasting and inactivity. We investigated how mitochondrial energetics respon...
A Surprising Molecule Not Required for Fatty Acid Handling by Adipocytes [0.03%]
一种令人惊讶的不需要的处理脂肪酸的分子不是脂肪细胞所需的分子
Caroline M Alexander
Caroline M Alexander
Maternal Excess Adiposity and Decidual Dyshomeostasis-A New Temporal Target for Intervention [0.03%]
母体肥胖和蜕膜功能障碍——一个新的干预时间窗口
Caroline Dunk
Caroline Dunk
Lysosome pH Dynamics in Physiology and Disease: Molecular Mechanisms and Therapeutic Insights [0.03%]
生理和疾病中的溶酶体pH动态变化：分子机制和治疗见解
Sonia Infante-Tadeo,Diane L Barber
Sonia Infante-Tadeo
Background: An acidic lysosomal lumen (pH ~4.5) is essential for the degradative and signaling functions of this organelle, which serves as a central hub for cellular homeostasis. Lysosome pH (pHlys), however, is not stat...
N-Acetylglucosamine Selectively Attenuates Neuroinflammation in a Mouse Model of Mitochondrial Dysfunction [0.03%]
N-乙酰葡萄糖胺选择性地减轻线粒体功能障碍小鼠模型中的神经炎症
Laura Jiménez-Sánchez,Paula Ruiz-López,Pilar González-García et al.
Laura Jiménez-Sánchez et al.
Aim: Mitochondrial dysfunction plays a central role in multiple neurodegenerative diseases, yet the temporal sequence of cellular events underlying neurodegeneration remains poorly defined. This study aimed to characteriz...
Myophosphorylase Knock Out Prevents the Exaggerated Exercise Pressor Reflex in Rats With Simulated Peripheral Artery Disease [0.03%]
骨骼肌磷酸果糖激酶基因敲除可抑制外周血管疾病大鼠运动时高血压反应增强的现象
Guillaume P Ducrocq,Laura Anselmi,Victor Ruiz-Velasco et al.
Guillaume P Ducrocq et al.
Aim: Controversy exists on which metabolites determine the exaggerated exercise pressor reflex (EPR) in peripheral artery disease (PAD). In decerebrated rats, we investigated the role played by lactate and hydrogen ions i...
Alms1 KO Rat: A New Model of Cardiometabolic Syndrome With Spontaneous Hypertension [0.03%]
自发性高血压的施舍症候群新模型-Alms1基因敲除大鼠
Ankita B Jaykumar,Sumit R Monu,Jiang Xu et al.
Ankita B Jaykumar et al.
Alström syndrome 1 (ALMS1) is a protein linked to Alström syndrome, a rare genetic disorder characterized by obesity, insulin resistance, hyperinsulinemia, and hypertension. Genetic studies have further associated Alms1 with hypertension ...
Cell Type-Specific Loss of SIRT1 in Central Amygdala Leads to Depression-Like Behaviors by Altering Neuronal Excitability in Mice [0.03%]
小鼠中央杏仁核神经元特异性Sirt1缺失通过改变神经元兴奋性导致类似抑郁的行为反应
Hui Huang,Xiao-Bao Ding,Yu-Wen Lin et al.
Hui Huang et al.
Aim: The current understanding of the underlying pathogenesis of depression is still limited. Silent information regulator 1 (SIRT1) has been shown to mediate the development of depression. However, the underlying mechani...
Shane K Maloney,Duncan Mitchell
Shane K Maloney
Piezo1-Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress [0.03%]
Piezo1介导的机械转导：协调足细胞和肾小球壁层上皮细胞对机械应力的动态反应
Maria Elena Melica,Giulia Antonelli,Anna Julie Peired et al.
Maria Elena Melica et al.
Aim: The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living...