Lateral size of graphene oxide determines differential cellular uptake and cell death pathways in Kupffer cells, LSECs, and hepatocytes [0.03%]
氧化石墨烯的横向尺寸决定了其在枯氏细胞、内皮细胞和肝细胞中不同的吸收及死亡途径
Jiulong Li,Xiang Wang,Kuo-Ching Mei et al.
Jiulong Li et al.
As a representative two-dimensional (2D) nanomaterial, graphene oxide (GO) has shown high potential in many applications due to its large surface area, high flexibility, and excellent dispersibility in aqueous solutions. These properties ma...
Dalila Iannotta,Man Yang,Christian Celia et al.
Dalila Iannotta et al.
Extracellular vesicles (EVs) are cell-released lipid-bilayer nanoparticles that contain biologically active cargo involved in physiological and pathological intercellular communication. In recent years, the therapeutic potential of EVs has ...
Spontaneous Formation of β-sheet Nano-barrels during the Early Aggregation of Alzheimer's Amyloid Beta [0.03%]
阿尔茨海默病淀粉样蛋白β aggregates早期自发形成β折叠纳米桶
Yunxiang Sun,Aleksandr Kakinen,Xulin Wan et al.
Yunxiang Sun et al.
Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we performed the first synergic in silico, in vitro and in vivo valid...
Jinping Wang,Beilu Zhang,Jingyu Sun et al.
Jinping Wang et al.
Porous nanomaterials with high surface area, tunable porosity, and large mesopores have recently received particular attention in cancer therapy and imaging. Introduction of additional pores to nanostructures not only endows the tunability ...
Inherited and acquired corona of coronavirus in the host: Inspiration from the biomolecular corona of nanoparticles [0.03%]
冠状病毒宿主面的继承与获得的冠层：源自纳米颗粒生物分子冠层的启发
Jie Gao,Li Zeng,Linlin Yao et al.
Jie Gao et al.
The family of coronavirus are named for their crown shape. Encoded by the genetic material inherited from the coronavirus itself, this intrinsic well-known "viral corona" is considered an "inherited corona". After contact with mucosa or the...
Lung-selective 25-hydroxycholesterol nanotherapeutics as a suppressor of COVID-19-associated cytokine storm [0.03%]
选择性肺靶向的25-羟基胆固醇纳米药物用于抑制新冠肺炎相关细胞因子风暴
Hyelim Kim,Han Sol Lee,June Hong Ahn et al.
Hyelim Kim et al.
In response to the coronavirus disease-19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), global efforts are focused on the development of new therapeutic interventions. For the treatment of COVID...
Amit Khurana,Prince Allawadhi,Isha Khurana et al.
Amit Khurana et al.
The emergency use authorization (EUA) by the US-FDA for two mRNA-based vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) has brought hope of addressing the COVID-19 pandemic which has killed more than two million people globally. ...
Towards Microfluidic-Based Exosome Isolation and Detection for Tumor Therapy [0.03%]
基于微流控的外泌体捕获与检测技术在肿瘤治疗中的应用展望
Jie Wang,Peng Ma,Daniel H Kim et al.
Jie Wang et al.
Exosomes are a class of cell-secreted, nano-sized extracellular vesicles with a bilayer membrane structure of 30-150 nm in diameter. Their discovery and application have brought breakthroughs in numerous areas, such as liquid biopsies, canc...
Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus [0.03%]
一种工程化的自我导航MnARK纳米疫苗诱导针对新型冠状病毒的强力保护性免疫能力
Yaling Wang,Yuping Xie,Jia Luo et al.
Yaling Wang et al.
Effective vaccines are vital to fight against the COVID-19 global pandemic. As a critical component of a subunit vaccine, the adjuvant is responsible for strengthening the antigen-induced immune responses. Here, we present a new nanovaccine...
2D MXenes with antiviral and immunomodulatory properties: A pilot study against SARS-CoV-2 [0.03%]
具有抗病毒和免疫调节性能的二维MXene材料：针对SARS-CoV-2的初步研究
Mehmet Altay Unal,Fatma Bayrakdar,Laura Fusco et al.
Mehmet Altay Unal et al.
Two-dimensional transition metal carbides/carbonitrides known as MXenes are rapidly growing as multimodal nanoplatforms in biomedicine. Here, taking SARS-CoV-2 as a model, we explored the antiviral properties and immune-profile of a large p...