Peng Yang,Athena Yue-Tung Lee,Jingjing Xue et al.
Peng Yang et al.
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) genome editing system has revolutionized the field of genome editing for therapeutic applications for genetic diseases and canc...
Emerging metallic nanotechnology platforms for cancer sensing and imaging [0.03%]
癌症检测及成像的新兴金属纳米技术平台
Masoud Negahdary,William Skinner,Samuel Mabbott et al.
Masoud Negahdary et al.
Despite major advances, the management of cancer remains one of the greatest unresolved challenges in medicine and a leading cause of death worldwide. Thus, improved, early, and minimally invasive diagnostics are urgently demanded. In recen...
Evin Gultepe,Raghnya Valluru,Nik Bear Brown et al.
Evin Gultepe et al.
Nanotechnology has transformed healthcare, leading to the clinical adoption of numerous nanomedical products. To evaluate their clinical translation, we analyzed all trials registered on ClinicalTrials.gov using a novel nanomedicine lexicon...
Nanofluidic delivery implant sustains localization and maximizes efficacy of intratumoral immunotherapy [0.03%]
纳米流体递送植入物能够维持肿瘤内免疫治疗的局部作用并最大化其疗效
Hsuan-Chen Liu,Nicola Di Trani,Marzia Conte et al.
Hsuan-Chen Liu et al.
Intratumoral immunotherapy holds promise for improving cancer treatment efficacy. However, rapid clearance from the tumor upon bolus volume injections limits efficacy and impedes assessment of dose-dependent effects on the tumor immune micr...
Peroxidase-catalyzed proximity labeling to survey the proteome of nanomaterial-cell interface during macropinocytosis-mediated internalization [0.03%]
过氧化物酶催化的临近标记技术用于在巨胞饮介导的内吞作用过程中纳米材料-细胞界面蛋白质组研究
Yushuang Wei,Xiangyang Li,Yao Gong et al.
Yushuang Wei et al.
Nanomaterials often need to interact with proteins on the plasma membrane to get cross and access their intracellular targets. Therefore, to fully understand the cell entry mechanism, it is of vital importance to gain a comprehensive insigh...
Efficient Intracellular Delivery of CRISPR-Cas9 Ribonucleoproteins Using Dendrimer Nanoparticles for Robust Genomic Editing [0.03%]
利用 dendrimer 纳米颗粒有效递送 crisper-cas9 核糖核蛋白进行高效的基因组编辑
Wathsala Liyanage,Gokul Kannan,Sujatha Kannan et al.
Wathsala Liyanage et al.
CRISPR-Cas9, a flexible and efficient genome editing technology, is currently limited by the challenge of delivering the large ribonucleoprotein complex intracellularly and into the nucleus. Existing delivery techniques/vectors are limited ...
Lymph node targeting of cyclosporine ameliorates ocular manifestations in a mouse model of systemic lupus erythematosus (SLE) via PD-L1 [0.03%]
通过PD-L1改善系统性红斑狼疮小鼠模型眼部表现
Raghu Ganugula,Kabirat T Babalola,Ingrid M Heyns et al.
Raghu Ganugula et al.
One-third of systemic lupus erythematosus (SLE) patients experience various degrees of ocular manifestations, with immunosuppressants recommended as a treatment option. Targeted immune suppression via oral administration is challenging due ...
Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials [0.03%]
用于癌症临床试验的聚合物纳米治疗药物的大规模生产研究
Md Musavvir Mahmud,Nikhil Pandey,Jeffrey A Winkles et al.
Md Musavvir Mahmud et al.
Nanotherapeutics have gained significant attention for the treatment of numerous cancers, primarily because they can accumulate in and/or selectively target tumors leading to improved pharmacodynamics of encapsulated drugs. The flexibility ...
Reprogramming the pancreatic cancer stroma and immune landscape by a silicasome nanocarrier delivering nintedanib, a protein tyrosine kinase inhibitor [0.03%]
硅纳米药物载体递送尼替尼达滨重编程胰腺癌基质和免疫微环境
Lijia Luo,Xiang Wang,Yu-Pei Liao et al.
Lijia Luo et al.
The prevailing desmoplastic stroma and immunosuppressive microenvironment within pancreatic ductal adenocarcinoma (PDAC) pose substantial challenges to therapeutic intervention. Despite the potential of protein tyrosine kinase (PTK) inhibit...
Nanoscopic and Functional Characterization of Keratinocyte-Originating Exosomes in the Wound Fluid of Non-Diabetic and Diabetic Chronic Wound Patients [0.03%]
非糖尿病和糖尿病慢性伤口患者伤口液中角质细胞源性外泌体的纳米特征及功能特性分析
Poornachander R Guda,Anu Sharma,Adam J Anthony et al.
Poornachander R Guda et al.
Exosomes, a class of extracellular vesicles of endocytic origin, play a critical role in paracrine signaling for successful cell-cell crosstalk in vivo. However, limitations in our current understanding of these circulating nanoparticles hi...