Peroxidase-catalyzed proximity labeling to survey the proteome of nanomaterial-cell interface during macropinocytosis-mediated internalization [0.03%]
过氧化物酶催化的临近标记技术用于在巨胞饮介导的内吞作用过程中纳米材料-细胞界面蛋白质组研究
Yushuang Wei,Xiangyang Li,Yao Gong et al.
Yushuang Wei et al.
Nanomaterials often need to interact with proteins on the plasma membrane to get cross and access their intracellular targets. Therefore, to fully understand the cell entry mechanism, it is of vital importance to gain a comprehensive insigh...
Efficient Intracellular Delivery of CRISPR-Cas9 Ribonucleoproteins Using Dendrimer Nanoparticles for Robust Genomic Editing [0.03%]
利用 dendrimer 纳米颗粒有效递送 crisper-cas9 核糖核蛋白进行高效的基因组编辑
Wathsala Liyanage,Gokul Kannan,Sujatha Kannan et al.
Wathsala Liyanage et al.
CRISPR-Cas9, a flexible and efficient genome editing technology, is currently limited by the challenge of delivering the large ribonucleoprotein complex intracellularly and into the nucleus. Existing delivery techniques/vectors are limited ...
Lymph node targeting of cyclosporine ameliorates ocular manifestations in a mouse model of systemic lupus erythematosus (SLE) via PD-L1 [0.03%]
通过PD-L1改善系统性红斑狼疮小鼠模型眼部表现
Raghu Ganugula,Kabirat T Babalola,Ingrid M Heyns et al.
Raghu Ganugula et al.
One-third of systemic lupus erythematosus (SLE) patients experience various degrees of ocular manifestations, with immunosuppressants recommended as a treatment option. Targeted immune suppression via oral administration is challenging due ...
Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials [0.03%]
用于癌症临床试验的聚合物纳米治疗药物的大规模生产研究
Md Musavvir Mahmud,Nikhil Pandey,Jeffrey A Winkles et al.
Md Musavvir Mahmud et al.
Nanotherapeutics have gained significant attention for the treatment of numerous cancers, primarily because they can accumulate in and/or selectively target tumors leading to improved pharmacodynamics of encapsulated drugs. The flexibility ...
Reprogramming the pancreatic cancer stroma and immune landscape by a silicasome nanocarrier delivering nintedanib, a protein tyrosine kinase inhibitor [0.03%]
硅纳米药物载体递送尼替尼达滨重编程胰腺癌基质和免疫微环境
Lijia Luo,Xiang Wang,Yu-Pei Liao et al.
Lijia Luo et al.
The prevailing desmoplastic stroma and immunosuppressive microenvironment within pancreatic ductal adenocarcinoma (PDAC) pose substantial challenges to therapeutic intervention. Despite the potential of protein tyrosine kinase (PTK) inhibit...
Nanoscopic and Functional Characterization of Keratinocyte-Originating Exosomes in the Wound Fluid of Non-Diabetic and Diabetic Chronic Wound Patients [0.03%]
非糖尿病和糖尿病慢性伤口患者伤口液中角质细胞源性外泌体的纳米特征及功能特性分析
Poornachander R Guda,Anu Sharma,Adam J Anthony et al.
Poornachander R Guda et al.
Exosomes, a class of extracellular vesicles of endocytic origin, play a critical role in paracrine signaling for successful cell-cell crosstalk in vivo. However, limitations in our current understanding of these circulating nanoparticles hi...
Hierarchical integration of DNA nanostructures and NanoGold onto a microchip facilitates covalent chemistry-mediated purification of circulating tumor cells in head and neck squamous cell carcinoma [0.03%]
分级整合DNA纳米结构和NanoGold到芯片上可促进头颈鳞癌循环肿瘤细胞的共价化学介导纯化
Na Sun,Ceng Zhang,Jing Wang et al.
Na Sun et al.
It is well-established that the combined use of nanostructured substrates and immunoaffinity agents can enhance the cell-capture performance of the substrates, thus offering a practical solution to effectively capture circulating tumor cell...
Miguel A Moreno-Gonzalez,Oscar A Ortega-Rivera,Nicole F Steinmetz
Miguel A Moreno-Gonzalez
Atherosclerosis is an immune-mediated chronic inflammatory disease that leads to the development of fatty plaques in the arterial walls, ultimately increasing the risk of thrombosis, stroke, and myocardial infarction. The immune response in...
Eradication of Bacterial Persister Cells By Leveraging Their Low Metabolic Activity Using Adenosine Triphosphate Coated Gold Nanoclusters [0.03%]
利用腺三磷分子修饰金纳米团簇根除细菌休眠菌丝体细胞研究
Laurent A Bekale,Devesh Sharma,Brian Bacacao et al.
Laurent A Bekale et al.
Bacteria first develop tolerance after antibiotic exposure; later genetic resistance emerges through the population of tolerant bacteria. Bacterial persister cells are the multidrug-tolerant subpopulation within an isogenic bacteria culture...
High-Dose Paclitaxel and its Combination with CSF1R Inhibitor in Polymeric Micelles for Chemoimmunotherapy of Triple Negative Breast Cancer [0.03%]
聚多肽胶束负载高剂量化疗药物白蛋白结合型紫杉醇联合CSF1R抑制剂用于三阴性乳腺癌的化疗免疫治疗
Chaemin Lim,Duhyeong Hwang,Mostafa Yazdimamaghani et al.
Chaemin Lim et al.
The presence of immunosuppressive immune cells in tumors is a significant barrier to the generation of therapeutic immune responses. Similarly, in vivo triple-negative breast cancer (TNBC) models often contain prevalent, immunosuppressive t...