Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking [0.03%]
非生物纳米材料和纳米载体的胞吞作用：抑制膜转运
Pooyan Makvandi,Meiling Chen,Rossella Sartorius et al.
Pooyan Makvandi et al.
Humans are exposed to nanoscopical nanobiovectors (e.g. coronavirus SARS-CoV-2) as well as abiotic metal/carbon-based nanomaterials that enter cells serendipitously or intentionally. Understanding the interactions of cell membranes with the...
Systemic antiviral immunization by virus-mimicking nanoparticles-decorated erythrocytes [0.03%]
病毒模拟纳米颗粒修饰的红细胞全身抗病毒免疫注射
Lu Wang,Xinyue Wang,Fengmin Yang et al.
Lu Wang et al.
New vaccine technologies are urgently needed to produce safe and effective vaccines in a more timely manner to prevent future infectious disease pandemics. Here, we describe erythrocyte-mediated systemic antiviral immunization, a versatile ...
Antiviral nanoparticles for sanitizing surfaces: A roadmap to self-sterilizing against COVID-19 [0.03%]
用于表面消毒的抗病毒纳米颗粒：对抗COVID-19的自消毒路线图
Neil Lin,Daksh Verma,Nikhil Saini et al.
Neil Lin et al.
Nanoparticles provide new opportunities in merging therapeutics and new materials, with current research efforts just beginning to scratch the surface of their diverse benefits and potential applications. One such application, the use of in...
Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells [0.03%]
抗体在金纳米颗粒上的协同吸附及用于迫使自然杀伤细胞杀死人类免疫缺陷病毒感染的T细胞
Antonio Astorga-Gamaza,Michele Vitali,Mireya L Borrajo et al.
Antonio Astorga-Gamaza et al.
HIV represents a persistent infection which negatively alters the immune system. New tools to reinvigorate different immune cell populations to impact HIV are needed. Herein, a novel nanotool for the specific enhancement of the natural kill...
Platelet membrane and stem cell exosome hybrid enhances cellular uptake and targeting to heart injury [0.03%]
platelet膜和干细胞外泌体混合增强细胞摄取和针对心脏损伤作用
Shiqi Hu,Xianyun Wang,Zhenhua Li et al.
Shiqi Hu et al.
Exosomes from mesenchymal stem cells have been largely studied as therapeutics to treat myocardial infarctions. However, exosomes injected for therapeutic purposes face a number of challenges, including competition from exosomes already in ...
Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy [0.03%]
用于抗癌治疗的自组装肽和蛋白质纳米结构：靶向递送、刺激响应装置和免疫疗法
Masoud Delfi,Rossella Sartorius,Milad Ashrafizadeh et al.
Masoud Delfi et al.
Self-assembled peptides and proteins possess tremendous potential as targeted drug delivery systems and key applications of these well-defined nanostructures reside in anti-cancer therapy. Peptides and proteins can self-assemble into nanost...
TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2 [0.03%]
负载单个Ag原子的TiO₂纳米酶用于消除SARS-CoV-2病毒
Daji Wang,Bin Zhang,Hui Ding et al.
Daji Wang et al.
The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO2 supported single-atom nanozyme contai...
Lateral size of graphene oxide determines differential cellular uptake and cell death pathways in Kupffer cells, LSECs, and hepatocytes [0.03%]
氧化石墨烯的横向尺寸决定了其在枯氏细胞、内皮细胞和肝细胞中不同的吸收及死亡途径
Jiulong Li,Xiang Wang,Kuo-Ching Mei et al.
Jiulong Li et al.
As a representative two-dimensional (2D) nanomaterial, graphene oxide (GO) has shown high potential in many applications due to its large surface area, high flexibility, and excellent dispersibility in aqueous solutions. These properties ma...
Dalila Iannotta,Man Yang,Christian Celia et al.
Dalila Iannotta et al.
Extracellular vesicles (EVs) are cell-released lipid-bilayer nanoparticles that contain biologically active cargo involved in physiological and pathological intercellular communication. In recent years, the therapeutic potential of EVs has ...
Spontaneous Formation of β-sheet Nano-barrels during the Early Aggregation of Alzheimer's Amyloid Beta [0.03%]
阿尔茨海默病淀粉样蛋白β aggregates早期自发形成β折叠纳米桶
Yunxiang Sun,Aleksandr Kakinen,Xulin Wan et al.
Yunxiang Sun et al.
Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we performed the first synergic in silico, in vitro and in vivo valid...