A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold cluster [0.03%]
COVID-19动物模型中瑞德西韦与金簇的比较研究：金簇疗效更佳
Zhesheng He,Fei Ye,Chunyu Zhang et al.
Zhesheng He et al.
While gold compound have been approved for Rheumatoid arthritis treatment as it well suppresses inflammatory cytokines of patients, no such treatment is currently available for COVID-19 treatment in vivo . We firstly disclose gold cluster y...
Mechanistic understanding of the aspect ratio-dependent adjuvanticity of engineered aluminum oxyhydroxide nanorods in prophylactic vaccines [0.03%]
探究工程氧化铝纳米棒在预防疫苗中以长径比决定佐剂活性的机制
Zhihui Liang,Xin Wang,Ge Yu et al.
Zhihui Liang et al.
Aluminum oxyhydroxide (AlOOH) adjuvants are widely used in human vaccines. However, the interaction mechanisms at the material-bio interface, and further understandings on physicochemical property-dependent modulation of the immune response...
Metformin Bicarbonate-Mediated Efficient RNAi for Precise Targeting of TP53 Deficiency in Colon and Rectal Cancers [0.03%]
用于精确靶向结直肠癌TP53缺陷的美迪霉素碳酸盐介导的有效RNA干扰疗法
Jiangsheng Xu,Yunhua Liu,Sheng Liu et al.
Jiangsheng Xu et al.
Colon and rectal cancers are the leading causes of cancer-related deaths in the United States and effective targeted therapies are in need for treating them. Our genomic analyses show hemizygous deletion of TP53, an important tumor suppress...
Principles for optimization and validation of mRNA lipid nanoparticle vaccines against COVID-19 using 3D bioprinting [0.03%]
使用3D生物打印优化和验证针对COVID-19的mRNA脂质纳米颗粒疫苗的原则
Massimiliano Papi,Daniela Pozzi,Valentina Palmieri et al.
Massimiliano Papi et al.
BioNTech/Pfizer's Comirnaty and Moderna's SpikeVax vaccines consist in mRNA encapsulated in lipid nanoparticles (LNPs). The modularity of the delivery platform and the manufacturing possibilities provided by microfluidics let them look like...
Amantadine-assembled nanostimulator enhances dimeric RBD antigen-elicited cross-neutralization against SARS-CoV-2 strains [0.03%]
Assembly素纳米刺激剂增强二聚体RBD抗原对SARS-CoV-2株系的交叉中和性
Ye Zhang,Ruixin Wang,Chunyan He et al.
Ye Zhang et al.
There is an urgent need to develop new vaccination strategies to elevate the cross-neutralization against different SARS-CoV-2 strains. In this study, we construct the spherical amantadine-assembled nanostimulator (AAS). Amantadine as immun...
Nanotechnology for Pain Management: Current and Future Therapeutic Interventions [0.03%]
纳米技术在疼痛管理中的应用：当前和未来的治疗干预措施
Divya Bhansali,Shavonne L Teng,Caleb S Lee et al.
Divya Bhansali et al.
Pain is one of the most common medical conditions and affects more Americans than diabetes, heart disease, and cancer combined. Current pain treatments mainly rely on opioid analgesics and remain unsatisfactory. The life-threatening side ef...
Anti-SARS-CoV-1 and -2 nanobody engineering towards avidity-inspired therapeutics [0.03%]
针对SARS-CoV-1和-2的纳米抗体工程以启发avidity治疗剂的发展
Eugene M Obeng,Christian K O Dzuvor,Michael K Danquah
Eugene M Obeng
In the past two decades, the emergence of coronavirus diseases has been dire distress on both continental and global fronts and has resulted in the search for potent treatment strategies. One crucial challenge in this search is the recurren...
Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation [0.03%]
用于人类多能干细胞的维持和分化的微/纳米工程技术创新技术
Sajedeh Nasr Esfahani,Agnes M Resto Irizarry,Xufeng Xue et al.
Sajedeh Nasr Esfahani et al.
Human pluripotent stem cells (hPSCs) are a promising source of cells for cell replacement-based therapies as well as modeling human development and diseases in vitro. However, achieving fate control of hPSC with a high yield and specificity...
The success of nanomedicine [0.03%]
纳米医学的成功
Twan Lammers,Mauro Ferrari
Twan Lammers
In recent years, the promise and prospects of nanomedicine have been controversially discussed. We here argue that nanomedicine has undeniably been successful, not only academically and preclinically, but also industrially and clinically. T...
Self-resetting molecular probes for nucleic acids detection enabled by fuel dissipative systems [0.03%]
由燃料耗散体系实现的用于核酸检测的自复位分子探针
Na Li,Yuee Zhao,Yu Liu et al.
Na Li et al.
A once-in-a-century global public health crisis, the COVID-19 pandemic has damaged human health and world economy greatly. To help combat the virus, we report a self-resetting molecular probe capable of repeatedly detecting SARS-CoV-2 RNA, ...