One-by-one single-molecule counting method for digital quantification of SARS-CoV-2 RNA [0.03%]
用于SARS-CoV-2 RNA数字化定量的一对一单分子计数法
Weiliang Liu,Desheng Chen,Hongru Pian et al.
Weiliang Liu et al.
Digital counting individual nucleic acid molecule is of great significance for fundamental biological research and accurate diagnosis of genetic diseases, which is hard to achieve with existing single-molecule detection technologies. Herein...
Multivalent ACE2 engineering-A promising pathway for advanced coronavirus nanomedicine development [0.03%]
多功能ACE2工程-用于先进冠状病毒纳米医学开发的有希望的途径
Eugene M Obeng,Isaac Fianu,Michael K Danquah
Eugene M Obeng
The spread of coronavirus diseases has resulted in a clarion call to develop potent drugs and vaccines even as different strains appear beyond human prediction. An initial step that is integral to the viral entry into host cells results fro...
Spherical neutralizing aptamer suppresses SARS-CoV-2 Omicron escape [0.03%]
球形中和适配体可抑制SARS-CoV-2奥密克戎逃逸
Miao Sun,Zijing Wu,Jialu Zhang et al.
Miao Sun et al.
Recently, the SARS-CoV-2 Omicron has spread very quickly worldwide. Several studies have indicated that the Omicron variant causes a substantial evasion of the humoral immune response and the majority of existing SARS-CoV-2 neutralizing ant...
A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold cluster [0.03%]
COVID-19动物模型中瑞德西韦与金簇的比较研究：金簇疗效更佳
Zhesheng He,Fei Ye,Chunyu Zhang et al.
Zhesheng He et al.
While gold compound have been approved for Rheumatoid arthritis treatment as it well suppresses inflammatory cytokines of patients, no such treatment is currently available for COVID-19 treatment in vivo . We firstly disclose gold cluster y...
Mechanistic understanding of the aspect ratio-dependent adjuvanticity of engineered aluminum oxyhydroxide nanorods in prophylactic vaccines [0.03%]
探究工程氧化铝纳米棒在预防疫苗中以长径比决定佐剂活性的机制
Zhihui Liang,Xin Wang,Ge Yu et al.
Zhihui Liang et al.
Aluminum oxyhydroxide (AlOOH) adjuvants are widely used in human vaccines. However, the interaction mechanisms at the material-bio interface, and further understandings on physicochemical property-dependent modulation of the immune response...
Metformin Bicarbonate-Mediated Efficient RNAi for Precise Targeting of TP53 Deficiency in Colon and Rectal Cancers [0.03%]
用于精确靶向结直肠癌TP53缺陷的美迪霉素碳酸盐介导的有效RNA干扰疗法
Jiangsheng Xu,Yunhua Liu,Sheng Liu et al.
Jiangsheng Xu et al.
Colon and rectal cancers are the leading causes of cancer-related deaths in the United States and effective targeted therapies are in need for treating them. Our genomic analyses show hemizygous deletion of TP53, an important tumor suppress...
Principles for optimization and validation of mRNA lipid nanoparticle vaccines against COVID-19 using 3D bioprinting [0.03%]
使用3D生物打印优化和验证针对COVID-19的mRNA脂质纳米颗粒疫苗的原则
Massimiliano Papi,Daniela Pozzi,Valentina Palmieri et al.
Massimiliano Papi et al.
BioNTech/Pfizer's Comirnaty and Moderna's SpikeVax vaccines consist in mRNA encapsulated in lipid nanoparticles (LNPs). The modularity of the delivery platform and the manufacturing possibilities provided by microfluidics let them look like...
Amantadine-assembled nanostimulator enhances dimeric RBD antigen-elicited cross-neutralization against SARS-CoV-2 strains [0.03%]
Assembly素纳米刺激剂增强二聚体RBD抗原对SARS-CoV-2株系的交叉中和性
Ye Zhang,Ruixin Wang,Chunyan He et al.
Ye Zhang et al.
There is an urgent need to develop new vaccination strategies to elevate the cross-neutralization against different SARS-CoV-2 strains. In this study, we construct the spherical amantadine-assembled nanostimulator (AAS). Amantadine as immun...
Nanotechnology for Pain Management: Current and Future Therapeutic Interventions [0.03%]
纳米技术在疼痛管理中的应用：当前和未来的治疗干预措施
Divya Bhansali,Shavonne L Teng,Caleb S Lee et al.
Divya Bhansali et al.
Pain is one of the most common medical conditions and affects more Americans than diabetes, heart disease, and cancer combined. Current pain treatments mainly rely on opioid analgesics and remain unsatisfactory. The life-threatening side ef...
Anti-SARS-CoV-1 and -2 nanobody engineering towards avidity-inspired therapeutics [0.03%]
针对SARS-CoV-1和-2的纳米抗体工程以启发avidity治疗剂的发展
Eugene M Obeng,Christian K O Dzuvor,Michael K Danquah
Eugene M Obeng
In the past two decades, the emergence of coronavirus diseases has been dire distress on both continental and global fronts and has resulted in the search for potent treatment strategies. One crucial challenge in this search is the recurren...