CeO2 nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics [0.03%]
基于代谢组学的纳米CeO2诱导肺纤维化的新机制研究
Li Cui,Xiang Wang,Xinyuan Zhao et al.
Li Cui et al.
CeO2 nanoparticles (NPs) have been shown to cause lung fibrosis, however, the exact underlying molecular mechanisms are poorly understood. In this study, we have conducted a mass spectrometry-based global metabolomic analysis of human bronc...
Fully implantable batteryless soft platforms with printed nanomaterial-based arterial stiffness sensors for wireless continuous monitoring of restenosis in real time [0.03%]
无电池全植入式软平台结合基于纳米材料的动脉僵硬度传感器实现无线连续实时监测再狭窄现象
Robert Herbert,Moataz Elsisy,Bruno Rigo et al.
Robert Herbert et al.
Atherosclerosis is a common cause of coronary artery disease and a significant factor in broader cardiovascular diseases, the leading cause of death. While implantation of a stent is a prevalent treatment of coronary artery disease, a frequ...
Prostate cancer extracellular vesicle digital scoring assay - a rapid noninvasive approach for quantification of disease-relevant mRNAs [0.03%]
前列腺癌细胞外囊泡数字评分测定-用于快速无创量化相关疾病mRNA的检测方法
Jasmine J Wang,Na Sun,Yi-Te Lee et al.
Jasmine J Wang et al.
Optimizing outcomes in prostate cancer (PCa) requires precision in characterization of disease status. This effort was directed at developing a PCa extracellular vesicle (EV) Digital Scoring Assay (DSA) for detecting metastasis and monitori...
A highly efficient needle-free-injection delivery system for mRNA-LNP vaccination against SARS-CoV-2 [0.03%]
一种高效的无针注射mRNA-LNP疫苗递送系统用于防治SARS-CoV-2病毒感染
Shanhong Mao,Shiyou Li,Yuxin Zhang et al.
Shanhong Mao et al.
Despite the various vaccines that have been developed to combat the coronavirus disease 2019 (COVID-19) pandemic, the persistent and unpredictable mutations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) require innovat...
Cordelia Sealy
Cordelia Sealy
ga1.
SARS-CoV-2 multi-variant rapid detector based on graphene transistor functionalized with an engineered dimeric ACE2 receptor [0.03%]
基于修饰了工程化二聚ACE2受体的石墨烯晶体管的SARS-CoV-2多变异快速检测器
Alice Romagnoli,Mattia D&#x;Agostino,Eleonora Pavoni et al.
Alice Romagnoli et al.
Reliable point-of-care (POC) rapid tests are crucial to detect infection and contain the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The emergence of several variants of concern (VOC) can reduce binding affinity ...
Multiplexed rapid antigen tests developed using multicolored nanoparticles and cross-reactive antibody pairs: Implications for pandemic preparedness [0.03%]
使用多色纳米粒子和交叉反应抗体对开发的多重快速抗原检测：对大流行病防范的意义
Helena de Puig,Irene Bosch,Nol Salcedo et al.
Helena de Puig et al.
Global public health infrastructure is unprepared for emerging pathogen epidemics, in part because diagnostic tests are not developed in advance. The recent Zika, Ebola, and SARS-CoV-2 virus epidemics are cases in point. We demonstrate here...
One-by-one single-molecule counting method for digital quantification of SARS-CoV-2 RNA [0.03%]
用于SARS-CoV-2 RNA数字化定量的一对一单分子计数法
Weiliang Liu,Desheng Chen,Hongru Pian et al.
Weiliang Liu et al.
Digital counting individual nucleic acid molecule is of great significance for fundamental biological research and accurate diagnosis of genetic diseases, which is hard to achieve with existing single-molecule detection technologies. Herein...
Multivalent ACE2 engineering-A promising pathway for advanced coronavirus nanomedicine development [0.03%]
多功能ACE2工程-用于先进冠状病毒纳米医学开发的有希望的途径
Eugene M Obeng,Isaac Fianu,Michael K Danquah
Eugene M Obeng
The spread of coronavirus diseases has resulted in a clarion call to develop potent drugs and vaccines even as different strains appear beyond human prediction. An initial step that is integral to the viral entry into host cells results fro...
Spherical neutralizing aptamer suppresses SARS-CoV-2 Omicron escape [0.03%]
球形中和适配体可抑制SARS-CoV-2奥密克戎逃逸
Miao Sun,Zijing Wu,Jialu Zhang et al.
Miao Sun et al.
Recently, the SARS-CoV-2 Omicron has spread very quickly worldwide. Several studies have indicated that the Omicron variant causes a substantial evasion of the humoral immune response and the majority of existing SARS-CoV-2 neutralizing ant...