On-Demand Synthesis of Antiseptics at the Site of Infection for Treatment of Otitis Media [0.03%]
耳源性中耳炎感染部位抗消毒剂的按需合成疗法
Jiayan Lang,Xiaojing Ma,Sophie S Liu et al.
Jiayan Lang et al.
Otitis media (OM) is the main reason for pediatric antibiotic prescriptions. The current treatment mandates a rigorous regimen of multidose antibiotics over 5-10 days. The systemic antibiotic exposure and often prematurely terminated treatm...
Nanotoxicology and Nanomedicine: The Yin and Yang of Nano-Bio Interactions for the New Decade [0.03%]
纳米毒理学与纳米医学：新十年纳米生物相互作用的阴阳关系
Olesja Bondarenko,Monika Mortimer,Anne Kahru et al.
Olesja Bondarenko et al.
Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been large...
Determination of the nanoparticle- and cell-specific toxicological mechanisms in 3D liver spheroids using scRNAseq analysis [0.03%]
基于scRNAseq分析的三维肝类器官中纳米粒子和细胞特异性毒性机制的研究
Jiulong Li,Graciel Diamante,In Sook Ahn et al.
Jiulong Li et al.
Engineered nanomaterials (ENMs) are commonly used in consumer products, allowing exposure to target organs such as the lung, liver, and skin that could lead to adverse health effects in humans. To better reflect on toxicological effects in ...
CeO2 nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics [0.03%]
基于代谢组学的纳米CeO2诱导肺纤维化的新机制研究
Li Cui,Xiang Wang,Xinyuan Zhao et al.
Li Cui et al.
CeO2 nanoparticles (NPs) have been shown to cause lung fibrosis, however, the exact underlying molecular mechanisms are poorly understood. In this study, we have conducted a mass spectrometry-based global metabolomic analysis of human bronc...
Fully implantable batteryless soft platforms with printed nanomaterial-based arterial stiffness sensors for wireless continuous monitoring of restenosis in real time [0.03%]
无电池全植入式软平台结合基于纳米材料的动脉僵硬度传感器实现无线连续实时监测再狭窄现象
Robert Herbert,Moataz Elsisy,Bruno Rigo et al.
Robert Herbert et al.
Atherosclerosis is a common cause of coronary artery disease and a significant factor in broader cardiovascular diseases, the leading cause of death. While implantation of a stent is a prevalent treatment of coronary artery disease, a frequ...
Prostate cancer extracellular vesicle digital scoring assay - a rapid noninvasive approach for quantification of disease-relevant mRNAs [0.03%]
前列腺癌细胞外囊泡数字评分测定-用于快速无创量化相关疾病mRNA的检测方法
Jasmine J Wang,Na Sun,Yi-Te Lee et al.
Jasmine J Wang et al.
Optimizing outcomes in prostate cancer (PCa) requires precision in characterization of disease status. This effort was directed at developing a PCa extracellular vesicle (EV) Digital Scoring Assay (DSA) for detecting metastasis and monitori...
A highly efficient needle-free-injection delivery system for mRNA-LNP vaccination against SARS-CoV-2 [0.03%]
一种高效的无针注射mRNA-LNP疫苗递送系统用于防治SARS-CoV-2病毒感染
Shanhong Mao,Shiyou Li,Yuxin Zhang et al.
Shanhong Mao et al.
Despite the various vaccines that have been developed to combat the coronavirus disease 2019 (COVID-19) pandemic, the persistent and unpredictable mutations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) require innovat...
Cordelia Sealy
Cordelia Sealy
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SARS-CoV-2 multi-variant rapid detector based on graphene transistor functionalized with an engineered dimeric ACE2 receptor [0.03%]
基于修饰了工程化二聚ACE2受体的石墨烯晶体管的SARS-CoV-2多变异快速检测器
Alice Romagnoli,Mattia D&#x;Agostino,Eleonora Pavoni et al.
Alice Romagnoli et al.
Reliable point-of-care (POC) rapid tests are crucial to detect infection and contain the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The emergence of several variants of concern (VOC) can reduce binding affinity ...
Multiplexed rapid antigen tests developed using multicolored nanoparticles and cross-reactive antibody pairs: Implications for pandemic preparedness [0.03%]
使用多色纳米粒子和交叉反应抗体对开发的多重快速抗原检测：对大流行病防范的意义
Helena de Puig,Irene Bosch,Nol Salcedo et al.
Helena de Puig et al.
Global public health infrastructure is unprepared for emerging pathogen epidemics, in part because diagnostic tests are not developed in advance. The recent Zika, Ebola, and SARS-CoV-2 virus epidemics are cases in point. We demonstrate here...