High-Dose Paclitaxel and its Combination with CSF1R Inhibitor in Polymeric Micelles for Chemoimmunotherapy of Triple Negative Breast Cancer [0.03%]
聚多肽胶束负载高剂量化疗药物白蛋白结合型紫杉醇联合CSF1R抑制剂用于三阴性乳腺癌的化疗免疫治疗
Chaemin Lim,Duhyeong Hwang,Mostafa Yazdimamaghani et al.
Chaemin Lim et al.
The presence of immunosuppressive immune cells in tumors is a significant barrier to the generation of therapeutic immune responses. Similarly, in vivo triple-negative breast cancer (TNBC) models often contain prevalent, immunosuppressive t...
Immunoengineered MXene nanosystem for mitigation of alloantigen presentation and prevention of transplant vasculopathy [0.03%]
免疫工程化MXene纳米系统用于抑制移植物抗原呈递并预防移植血管病变
Weiang Yan,Alireza Rafieerad,Keshav Narayan Alagarsamy et al.
Weiang Yan et al.
MXenes are an emerging class of nanomaterials with significant potential for applications in nanomedicine. Amongst MXene technologies, titanium carbide (Ti3C2Tx) nanomaterials are the most mature and have received significant attention to t...
Electric Tweezers [0.03%]
电动镊子
D L Fan,F Q Zhu,R C Cammarata et al.
D L Fan et al.
Electric tweezers utilize DC and AC electric fields through voltages applied on patterned electrodes to manipulate nanoentities suspended in a liquid. Nanowires with a large aspect ratio are particularly suitable for use in electric tweezer...
Could artificial intelligence revolutionize the development of nanovectors for gene therapy and mRNA vaccines? [0.03%]
人工智能能否革命基因疗法和mRNA疫苗的纳米载体开发？
Akbar Hasanzadeh,Michael R Hamblin,Jafar Kiani et al.
Akbar Hasanzadeh et al.
Gene therapy enables the introduction of nucleic acids like DNA and RNA into host cells, and is expected to revolutionize the treatment of a wide range of diseases. This growth has been further accelerated by the discovery of CRISPR/Cas tec...
Nanopore-based disease diagnosis using pathogen-derived tryptic peptides from serum [0.03%]
基于纳米孔的疾病诊断方法——利用血液来源的病原蛋白酶肽段
Wenshu Zheng,Julian G Saliba,Xiaojun Wei et al.
Wenshu Zheng et al.
Nanopore sensors have shown great utility in nucleic acid detection and sequencing approaches. Recent studies also indicate that current signatures produced by peptide-nanopore interactions can distinguish high purity peptide mixtures, but ...
Anqi Zhang,Jae-Hyun Lee,Charles M Lieber
Anqi Zhang
Bioelectronics explores the use of electronic devices for applications in signal transduction at their interfaces with biological systems. The miniaturization of the bioelectronic systems has enabled seamless integration at these interfaces...
Use of a Liver-targeting Nanoparticle Platform to Intervene in Peanut-induced anaphylaxis through delivery of an Ara h2 T-cell Epitope [0.03%]
一种肝靶向纳米颗粒平台通过递送花生蛋白Arachis hypogaea 2(TC206)的主要组织相容性复合体II类表位干预花生诱导的过敏反应
Qi Liu,Xiang Wang,Yu-Pei Liao et al.
Qi Liu et al.
To address the urgent need for safe food allergen immunotherapy, we have developed a liver-targeting nanoparticle platform, capable of intervening in allergic inflammation, mast cell release and anaphylaxis through the generation of regulat...
On-Demand Synthesis of Antiseptics at the Site of Infection for Treatment of Otitis Media [0.03%]
耳源性中耳炎感染部位抗消毒剂的按需合成疗法
Jiayan Lang,Xiaojing Ma,Sophie S Liu et al.
Jiayan Lang et al.
Otitis media (OM) is the main reason for pediatric antibiotic prescriptions. The current treatment mandates a rigorous regimen of multidose antibiotics over 5-10 days. The systemic antibiotic exposure and often prematurely terminated treatm...
Nanotoxicology and Nanomedicine: The Yin and Yang of Nano-Bio Interactions for the New Decade [0.03%]
纳米毒理学与纳米医学：新十年纳米生物相互作用的阴阳关系
Olesja Bondarenko,Monika Mortimer,Anne Kahru et al.
Olesja Bondarenko et al.
Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been large...
Determination of the nanoparticle- and cell-specific toxicological mechanisms in 3D liver spheroids using scRNAseq analysis [0.03%]
基于scRNAseq分析的三维肝类器官中纳米粒子和细胞特异性毒性机制的研究
Jiulong Li,Graciel Diamante,In Sook Ahn et al.
Jiulong Li et al.
Engineered nanomaterials (ENMs) are commonly used in consumer products, allowing exposure to target organs such as the lung, liver, and skin that could lead to adverse health effects in humans. To better reflect on toxicological effects in ...