Odyssey of a cancer nanoparticle: from injection site to site of action [0.03%]
抗癌纳米颗粒奇遇记：从注射到作用部位的旅程
Joseph W Nichols,You Han Bae
Joseph W Nichols
No chemotherapeutic drug can be effective until it is delivered to its target site. Nano-sized drug carriers are designed to transport therapeutic or diagnostic materials from the point of administration to the drug's site of action. This t...
Beyond Biomarkers: Identifying Cell State using Unbiased Nanosensor Arrays [0.03%]
超越生物标志物：使用无偏纳米传感器阵列识别细胞状态
Bradley Duncan,S Gokhan Elci,Vincent M Rotello
Bradley Duncan
Traditional cell detection based on biomarkers relies on specific lock-and-key recognition. However, many diseases either do not have obvious biomarkers or these markers are currently unknown. Unbiased sensor arrays based on nanoparticles u...
Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers [0.03%]
超稳定的四价RNA纳米颗粒癌症靶向传输体系
Farzin Haque,Dan Shu,Yi Shu et al.
Farzin Haque et al.
One of the advantages of nanotechnology is the feasibility to construct therapeutic particles carrying multiple therapeutics with defined structure and stoichiometry. The field of RNA nanotechnology is emerging. However, controlled assembly...
Guided Delivery of Polymer Therapeutics Using Plasmonic Photothermal Therapy [0.03%]
基于等离激元光热效应的聚合物药物导向传输体系
Adam J Gormley,Nate Larson,Shraddha Sadekar et al.
Adam J Gormley et al.
In most drug delivery systems the clinician does not have control over the location of drug delivery after the therapeutic has been administered. As the location of the tumor mass is often known in many patients, a therapy system which enab...
Gang Liu,Magdalena Swierczewska,Seulki Lee et al.
Gang Liu et al.
Gene therapy has great potential to bring tremendous changes in treatment of various diseases and disorders. However, one of the impediments to successful gene therapy is the inefficient delivery of genes to target tissues and the inability...
In Vivo Modulation of Dendritic Cells by Engineered Materials: Towards New Cancer Vaccines [0.03%]
仿生材料在体内的树突状细胞调节：朝向新的癌症疫苗技术发展
Jaeyun Kim,David J Mooney
Jaeyun Kim
Therapeutic cancer vaccines are emerging as novel and potent approaches to treat cancer. These vaccines enhance the body's immune response to cancerous cells, and dendritic cells (DCs), an initiator of adaptive immunity, are a key cell type...
Advances in Resistive Pulse Sensors: Devices bridging the void between molecular and microscopic detection [0.03%]
阻抗脉冲传感器的新进展：分子与微观检测间的桥梁设备
Darby Kozak,Will Anderson,Robert Vogel et al.
Darby Kozak et al.
Since the first reported use of a biological ion channel to detect differences in single stranded genomic base pairs in 1996, a renaissance in nanoscale resistive pulse sensors has ensued. This resurgence of a technique originally outlined ...
Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials [0.03%]
仿生纳米材料工程化细胞表面医学疗法
Matthias T Stephan,Darrell J Irvine
Matthias T Stephan
Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of...
Hao Hong,Ting Gao,Weibo Cai
Hao Hong
Nanoparticle-based molecular imaging has emerged as an interdisciplinary field which involves physics, chemistry, engineering, biology, and medicine. Single-walled carbon nanotubes (SWCNTs) have unique properties which make them suitable fo...
Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery [0.03%]
表面对纳米技术与胞吞作用之间的联系：对非病毒基因传递的影响
Andrew F Adler,Kam W Leong
Andrew F Adler
Significant effort continues to be exerted toward the improvement of transfection mediated by nonviral vectors. These endeavors are often focused on the design of particulate carriers with properties that encourage efficient accumulation at...