Lixue Wang,Waseem Asghar,Utkan Demirci et al.
Lixue Wang et al.
Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the peripheral bloodstream. CTCs hold the key to understanding the biology of metastasis and also play a vital role in cancer diagnosis, prognosis, disease ...
High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model [0.03%]
基于小动物肿瘤模型的纳米药物体内精确诊断及定位的高通量研究方法学探索
Bryan Ronain Smith,Cristina Zavaleta,Jarrett Rosenberg et al.
Bryan Ronain Smith et al.
Nanoparticles are under active investigation for the detection and treatment of cancer. Yet our understanding of nanoparticle delivery to tumors is limited by our ability to observe the uptake process on its own scale in living subjects. We...
Chang Soo Kim,Bradley Duncan,Brian Creran et al.
Chang Soo Kim et al.
Drug delivery systems (DDSs) face several challenges including site-specific delivery, stability, and the programmed release of drugs. Engineered nanoparticle (NP) surfaces with responsive moieties can enhance the efficacy of DDSs for in vi...
Nanoelectronics-biology frontier: From nanoscopic probes for action potential recording in live cells to three-dimensional cyborg tissues [0.03%]
纳米电子学-生物学前沿：从活细胞中记录动作电位的纳probe到三维半机械组织
Xiaojie Duan,Tian-Ming Fu,Jia Liu et al.
Xiaojie Duan et al.
Semiconductor nanowires configured as the active channels of field-effect transistors (FETs) have been used as detectors for high-resolution electrical recording from single live cells, cell networks, tissues and organs. Extracellular measu...
Li Tang,Jianjun Cheng
Li Tang
Nanomedicine, the use of nanotechnology for biomedical applications, has potential to change the landscape of the diagnosis and therapy of many diseases. In the past several decades, the advancement in nanotechnology and material science ha...
Joyce Y Wong,John McDonald,Micki Taylor-Pinney et al.
Joyce Y Wong et al.
Tailored materials with tunable properties are crucial for applications as biomaterials, for drug delivery, as functional coatings, or as lightweight composites. An emerging paradigm in designing such materials is the construction of hierar...
Anthracycline Nano-Delivery Systems to Overcome Multiple Drug Resistance: A Comprehensive Review [0.03%]
用于克服多重耐药性的蒽环类纳米递送系统：综述文章
Ping Ma,Russell J Mumper
Ping Ma
Anthracyclines (doxorubicin, daunorubicin, and idarubicin) are very effective chemotherapeutic drugs to treat many cancers; however, the development of multiple drug resistance (MDR) is one of the major limitations for their clinical applic...
Theranostic agents for intracellular gene delivery with spatiotemporal imaging [0.03%]
具有时空成像的细胞内基因传递治疗诊断剂
Jennifer M Knipe,Jonathan T Peters,Nicholas A Peppas
Jennifer M Knipe
Gene therapy is the modification of gene expression to treat a disease. However, efficient intracellular delivery and monitoring of gene therapeutic agents is an ongoing challenge. Use of theranostic agents with suitable targeted, controlle...
Solid-State and Biological Nanopore for Real-Time Sensing of Single Chemical and Sequencing of DNA [0.03%]
固态和生物纳米孔单分子化学实时分析及DNA测序研究进展
Farzin Haque,Jinghong Li,Hai-Chen Wu et al.
Farzin Haque et al.
Sensitivity and specificity are two most important factors to take into account for molecule sensing, chemical detection and disease diagnosis. A perfect sensitivity is to reach the level where a single molecule can be detected. An ideal sp...
Lara Yildirimer,Nguyen T K Thanh,Marilena Loizidou et al.
Lara Yildirimer et al.
In recent years, nanoparticles (NPs) have increasingly found practical applications in technology, research and medicine. The small particle size coupled to their unique chemical and physical properties is thought to underlie their exploita...