Core-Crosslinked Polymeric Micelles: Principles, Preparation, Biomedical Applications and Clinical Translation [0.03%]
核交联聚合物胶束：原理、制备、生物医药应用及临床转化
Marina Talelli,Matthias Barz,Cristianne J Rijcken et al.
Marina Talelli et al.
Polymeric micelles (PM) are extensively used to improve the delivery of hydrophobic drugs. Many different PM have been designed and evaluated over the years, and some of them have steadily progressed through clinical trials. Increasing evid...
Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom [0.03%]
纳米拓扑结构表面在干细胞命运控制中的作用：从机制生物学底层工程学的角度研究
Weiqiang Chen,Yue Shao,Xiang Li et al.
Weiqiang Chen et al.
During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with tissue/organ-specific nanoscale topographical cues to adopt diff...
A Multilayered Cell Culture Model for Transport Study in Solid Tumors: Evaluation of Tissue Penetration of Polyethyleneimine Based Cationic Micelles [0.03%]
用于固体肿瘤转运研究的多层细胞培养模型：聚乙烯亚胺基阳离子胶束组织渗透性的评价
Seiji Miura,Hidenori Suzuki,You Han Bae
Seiji Miura
Limited drug distribution is partially responsible for the efficacy gap between preclinical and clinical studies of nano-sized drug carriers for cancer therapy. In this study, we examined the transport behavior of cationic micelles formed f...
Nasim Annabi,Ali Tamayol,Su Ryon Shin et al.
Nasim Annabi et al.
Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been utilized for generation of a new ...
Euan McLeod,Aydogan Ozcan
Euan McLeod
Imaging object details with length scales below approximately 200 nm has been historically difficult for conventional microscope objective lenses because of their inability to resolve features smaller than one-half the optical wavelength. H...
Sandra Chapman,Marina Dobrovolskaia,Keyvan Farahani et al.
Sandra Chapman et al.
Recent advances in molecular imaging and nanotechnology are providing new opportunities for biomedical imaging with great promise for the development of novel imaging agents. The unique optical, magnetic, and chemical properties of material...
Nanotoxoid Vaccines [0.03%]
纳米类毒素疫苗
Che-Ming J Hu,Liangfang Zhang
Che-Ming J Hu
To improve innate defense against diseases, vaccine formulations are routinely administered to mount immune responses against disease-causing organisms or their associated toxins. These formulations are typically prepared with weakened form...
Nanomedicine in the Management of Microbial Infection - Overview and Perspectives [0.03%]
纳米医学在微生物感染管理中的应用-概述与展望
Xi Zhu,Aleksandar F Radovic-Moreno,Jun Wu et al.
Xi Zhu et al.
For more than 2 billion years, microbes have reigned on our planet, evolving or outlasting many obstacles they have encountered. In the 20th century, this trend took a dramatic turn with the introduction of antibiotics and vaccines. Neverth...
Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects [0.03%]
纳米粒子穿透细胞和组织屏障的相关挑战：现状与未来展望综述
Sutapa Barua,Samir Mitragotri
Sutapa Barua
Nanoparticles (NPs) have emerged as an effective modality for the treatment of various diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs including liposomes, polymer particles, micelles, dendrimers, q...
A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors [0.03%]
一种计算框架用于识别设计指南以增加靶向纳米颗粒渗透进入肿瘤的比例
Sabine Hauert,Spring Berman,Radhika Nagpal et al.
Sabine Hauert et al.
Targeted nanoparticles are increasingly being engineered for the treatment of cancer. By design, they can passively accumulate in tumors, selectively bind to targets in their environment, and deliver localized treatments. However, the penet...