Using the Power of Organic Synthesis for Engineering the Interactions of Nanoparticles with Biological Systems [0.03%]
利用有机合成的力量来工程纳米粒子与生物系统的相互作用
Tsukasa Mizuhara,Daniel F Moyano,Vincent M Rotello
Tsukasa Mizuhara
The surface properties of nanoparticles (NPs) dictate their interaction with the outside world. The use of precisely designed molecular ligands to control NP surface properties provides an important toolkit for modulating their interaction ...
Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery [0.03%]
基于肽的自组装纳米结构：朝向靶向药物输送的智能纳米材料
Neda Habibi,Nazila Kamaly,Adnan Memic et al.
Neda Habibi et al.
Self-assembly of peptides can yield an array of well-defined nanostructures that are highly attractive nanomaterials for many biomedical applications such as drug delivery. Some of the advantages of self-assembled peptide nanostructures ove...
Wang Ma,Andrew G Cheetham,Honggang Cui
Wang Ma
The convergence of nanoscience and drug delivery has prompted the formation of the field of nanomedicine, one that exploits the novel physicochemical and biological properties of nanostructures for improved medical treatments and reduced si...
Bomy Lee Chung,Michael J Toth,Nazila Kamaly et al.
Bomy Lee Chung et al.
The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as...
Junfeng Shi,Bing Xu
Junfeng Shi
Being driven by non-covalent interactions, the formation of functional assemblies (or aggregates) of small molecules at nanoscale is a more common process in water than one would think. While most efforts on self-assembly in cellular enviro...
RNA as a stable polymer to build controllable and defined nanostructures for material and biomedical applications [0.03%]
用于材料及生物医学应用的可调控定义纳米结构的稳定聚合物RNA构建单元
Hui Li,Taek Lee,Thomas Dziubla et al.
Hui Li et al.
The value of polymers is manifested in their vital use as building blocks in material and life sciences. Ribonucleic acid (RNA) is a polynucleic acid, but its polymeric nature in materials and technological applications is often overlooked ...
Alina Y Rwei,Weiping Wang,Daniel S Kohane
Alina Y Rwei
Externally triggerable drug delivery systems provide a strategy for the delivery of therapeutic agents preferentially to a target site, presenting the ability to enhance therapeutic efficacy while reducing side effects. Light is a versatile...
Alexander S Cheung,David J Mooney
Alexander S Cheung
Immunotherapy is a promising treatment modality for cancer as it can promote specific and durable anti-cancer responses. However, limitations to current approaches remain. Therapeutics administered as soluble injections often require high d...
Heather Herd Gustafson,Dolly Holt-Casper,David W Grainger et al.
Heather Herd Gustafson et al.
Phagocytes are key cellular participants determining important aspects of host exposure to nanomaterials, initiating clearance, biodistribution and the tenuous balance between host tolerance and adverse nanotoxicity. Macrophages in particul...
Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance [0.03%]
利用纳米载体共递送siRNA和药物以克服癌症抗性
Mar Creixell,Nicholas A Peppas
Mar Creixell
There are two main mechanisms by which cells become multidrug resistant (MDR): by increasing drug efflux pumps on the cell membrane and by increasing anti-apoptotic pathways. The use of nanotechnology to develop nanodelivery systems has all...