The future of diagnosing NASH - could a simple blood test be the key? [0.03%]
诊断NASH的未来——简单的血液检测能成为关键吗？
Sven Francque,Luisa Vonghia
Sven Francque
Elastography methods for the non-invasive assessment of portal hypertension [0.03%]
无创评估门脉高压的弹性图技术方法学研究进展
Davide Roccarina,Matteo Rosselli,Joan Genesca et al.
Davide Roccarina et al.
The gold standard to assess the presence and severity of portal hypertension remains the hepatic vein pressure gradient, however the recent development of non-invasive assessment using elastography techniques offers valuable alternatives. I...
Pharmacoepigenetics and pharmacoepigenomics of gastrointestinal cancers [0.03%]
胃肠癌症的药理表观遗传学和药理 epigenomics
Angela Lopomo,Fabio Coppedè
Angela Lopomo
Our understanding of the epigenetic changes occurring in gastrointestinal cancers has gained tremendous advancements in recent years, and some epigenetic biomarkers are already translated into the clinics for cancer diagnostics. In parallel...
Gerard Cummins,Diana E Yung,Ben F Cox et al.
Gerard Cummins et al.
A biomarker is a measurable indicator of normal biologic processes, pathogenic processes or pharmacological responses. The identification of a useful biomarker is challenging, with several hurdles to overcome before clinical adoption. This ...
Hand-foot skin reaction is a beneficial indicator of sorafenib therapy for patients with hepatocellular carcinoma: a systemic review and meta-analysis [0.03%]
雷公藤治疗类风湿关节炎的临床疗效及安全性系统评价和meta分析研究方案
Ping Wang,Gang Tan,Mingxin Zhu et al.
Ping Wang et al.
Background: Sorafenib remains the only standard first-line drug for advanced hepatocellular carcinoma (HCC). Hand-foot skin reaction (HFSR) is a very common side-effect in patients treated with sorafenib, and also affects...
Natàlia Pascual-Argente,Jaume Puig-Junoy,Anna Llagostera-Punzano
Natàlia Pascual-Argente
There is an increasing interest in the indirect (or non-healthcare) costs of hepatitis C virus (HCV). Areas covered: Systematic review of original studies on the non-healthcare costs of HCV published in English or Spanish between January 20...
Bo Cao,Xin Zhou,Wanli Yang et al.
Bo Cao et al.
Colorectal cancer is a cancer of the digestive system with poor prognosis. Cell-free DNA has received much attention with its unique predominance, especially in colorectal cancer. Areas covered: This study has summarized recent advancements...
Molecular mechanisms and clinical implications of miRNAs in drug resistance of esophageal cancer [0.03%]
微小核糖核酸在食管癌药物耐药中的分子机制及临床意义
Wanli Yang,Jiaojiao Ma,Wei Zhou et al.
Wanli Yang et al.
With the increasing incidence of esophageal cancer, drug resistance is becoming a major obstacle to successful cancer therapy since chemotherapy is regarded as a curative approach to inhibit cancer cell proliferation. Despite the great prog...
The gallbladder polypoid-lesions conundrum: moving forward with controversy by looking back [0.03%]
胆囊息肉样病变争议：回顾过去，展望未来
Anan Xu,Hai Hu
Anan Xu
Gallbladder polypoid-lesions (GPs) are found in 5-10% of the general population. Although the majority of GPs are asymptomatic and benign in nature, some of them can develop into cancer, which carries a poor prognosis. Currently, the risk f...