Glecaprevir + pibrentasvir (ABT493 + ABT-530) for the treatment of Hepatitis C [0.03%]
用于治疗丙型肝炎的 glecaprevir 加 pibrentasvir（ABT493 加 ABT-530）疗法
Hope Hubbard,Eric Lawitz
Hope Hubbard
Glecaprevir (formerly ABT-493, pangenotypic NS3/4A protease inhibitor) and pibrentasvir (formerly ABT-530, pangenotypic NS5A inhibitor) are second generation direct acting antivirals (DAA) for the treatment of chronic Hepatitis C (HCV). It ...
Supersonic shear imaging for the diagnosis of liver fibrosis and portal hypertension in liver diseases: a meta-analysis [0.03%]
肝病患者肝纤维化和门脉高压诊断的超声剪切波弹性成像meta分析
Han Deng,Xingshun Qi,Tiansong Zhang et al.
Han Deng et al.
Background and aims: The meta-analysis aimed to summarize the technical success rate of supersonic shear imaging (SSI) and to evaluate the diagnostic performance of liver and spleen stiffness measurement (LSM and SSM) wit...
Dong-Bo Wu,Meng-Lan Wang,En-Qiang Chen et al.
Dong-Bo Wu et al.
In addition to being crucial for host immune defense, vitamin D is involved in cell proliferation, apoptosis, differentiation, inflammation, invasion and metastasis, angiogenesis and micro-RNA modulation. To date, clinical studies have demo...
Dipesh H Vasant,Amol Sharma,Jigar Bhagatwala et al.
Dipesh H Vasant et al.
Although neurogastroenterology and motility (NGM) disorders affect 50% of patients seen in clinics, many gastroenterologists receive limited NGM training. One-month apprenticeship-based NGM training has been provided at ten centers in the U...
Anjan K Banerjee,Valerio Celentano,Jim Khan et al.
Anjan K Banerjee et al.
About 10% of oesophagogastroduodenoscopies (OGDs) and colonoscopies are done for investigation of iron deficiency anemia (IDA) . Much of the existing guidance on investigation of IDA predates CRC screening, which has driven significant impr...
Outcomes of treatment with sorafenib in Egyptian patients with hepatocellular carcinoma: a retrospective cohort study [0.03%]
西奥佩尼治疗埃及肝细胞癌患者的效果：一项队列研究
Yousery Nada,Noha Rashad,Mai Eissa et al.
Yousery Nada et al.
Background: Sorafenib is the standard of care, first line treatment for advanced HCC. This study aims to evaluate real-life efficacy and safety of sorafenib in Egyptian patients with Hepatocellular carcinoma (HCC). ...
Nasogastric aspiration/lavage in patients with gastrointestinal bleeding: a review of the evidence [0.03%]
消化道出血患者鼻胃吸引/冲洗的证据回顾
Stamatis Karakonstantis,Emmanouil Tzagkarakis,Dimitra Kalemaki et al.
Stamatis Karakonstantis et al.
The usefulness of nasogastric aspiration and nasogastric lavage in patients with gastrointestinal bleeding is controversial, as evidenced by conflicting recommendations, both among and within society guidelines. Areas covered: Considering t...
Advances in mesenchymal stromal cell therapy in the management of Crohn's disease [0.03%]
间充质基质细胞治疗在克罗恩病管理中的新进展
Hajir Ibraheim,Chiara Giacomini,Zain Kassam et al.
Hajir Ibraheim et al.
The aim of therapy in Crohn's disease (CD) is induction and maintenance of remission, promotion of mucosal healing and restoration of quality of life. Even the best treatment regimes, including combinations of biologics and immunomodulators...
The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery [0.03%]
口服纳米药物递送面临的生物学挑战和药理学机遇
Darren Michael Moss,Paul Curley,Hannah Kinvig et al.
Darren Michael Moss et al.
Nano-scale formulations are being developed to improve the delivery of orally administered medicines, and the interactions between nanoformulations and the gastrointestinal luminal, mucosal and epithelial environment is currently being inve...
The use of obeticholic acid for the management of non-viral liver disease: current clinical practice and future perspectives [0.03%]
奥贝胆酸在非病毒性肝病管理中的应用：当前临床实践和未来展望
Stefano Gitto,Valeria Guarneri,Alessandro Sartini et al.
Stefano Gitto et al.
Farnesoid X nuclear receptor is involved in the regulation of lipid and glucose metabolism, though mainly in the homeostasis of bile acids. Indeed, the agonists of farnesoid X nuclear receptor represent promising drugs. Areas covered: Obeti...