Zinc finger protein 468 up-regulation of TFAM contributes to the malignant growth and cisplatin resistance of breast cancer cells [0.03%]
锌指蛋白468通过上调TFAM促进乳腺癌细胞的恶性增殖和顺铂抗性
Zhaoyang Jia,Feng Wang,Gongzhuo Li et al.
Zhaoyang Jia et al.
Background: Because of the progress on the diagnosis and treatment for patients with breast cancer (BC), the overall survival of the patients has been improved. However, a number of BC patients cannot benefit from the exi...
Ultrasonic microbubbles promote mesenchymal stem cell homing to the fibrotic liver via upregulation of CXCR4 expression [0.03%]
超声微气泡通过上调CXCR4表达促进间充质干细胞归巢至肝纤维化部位
Heming Xu,Yize Huang,Fasu Zhang et al.
Heming Xu et al.
Objective: To investigate the mechanism of ultrasound microbubbles (UTMB) promoting stem cells homing to fibrotic liver. Methods: Bone ...
Anti-cancer effects of Coix seed extract through KCTD9-mediated ubiquitination of TOP2A in lung adenocarcinoma [0.03%]
薏苡仁提取物通过KCTD9介导的TOP2A泛素化产生抗癌效果的研究
Jiuyang Jiang,Xue Li,Chun Zhang et al.
Jiuyang Jiang et al.
Background: Coix seed extract (CSE), a traditional Chinese medicine, has been reported as an adjunctive therapy in cancers. However, the molecular targets are largely unclear. The study is designed to unveil its function ...
Exosome-derived lncRNA A1BG-AS1 attenuates the progression of prostate cancer depending on ZC3H13-mediated m6A modification [0.03%]
exo衍生的lncRNA A1BG-AS1通过依赖ZC3H13介导的m6A修饰来减轻前列腺癌的发展进程
Zhi Yang,Yu Luo,Fan Zhang et al.
Zhi Yang et al.
Background: Exosome-derived long non-coding RNAs (lncRNAs) and N6-methyladenosine (m6A) modifications of lncRNAs have been shown crucial functions in prostate cancer (PCa). Herein, we aim to investigate the detailed mecha...
Human Parathyroid Hormone (1-34) accelerates skin wound healing through inducing cell migration via up-regulating the expression of Rac1 [0.03%]
人甲状旁腺激素(1-34)通过上调Rac1表达促进细胞迁移从而加速皮肤创伤愈合
Qingpeng Sun,Liya Zhou,Zhiyong Yu et al.
Qingpeng Sun et al.
Delayed wound healing is a public issue that imposes a significant burden on both society and the patients themselves. To date, although numerous methods have been developed to accelerate the speed of wound closure, the therapeutic effects ...
Non-mitotic proliferation of malignant cancer cells revealed through live-cell imaging of primary and cell-line cultures [0.03%]
通过活细胞成像技术揭示恶性癌细胞非有丝分裂增殖现象
Iram Shazia Tyagi,Ho Yin Calvin Tsui,Si Chen et al.
Iram Shazia Tyagi et al.
Introduction: Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti...
Cilostazol protects against degenerative cervical myelopathy injury and cell pyroptosis via TXNIP-NLRP3 pathway [0.03%]
西洛他唑通过TXNIP-NLRP3通路保护退行性颈髓损伤和细胞焦亡
Fei Xu,Zhuo Tian,Zhengguang Wang
Fei Xu
Degenerative cervical myelopathy (DCM) is one of the most common and serious neurological diseases. Cilostazol has protective effects of anterior horn motor neurons and prevented the cell apoptosis. However, there was no literatures of Cilo...
Role of reactive oxygen species in ultraviolet-induced photodamage of the skin [0.03%]
活性氧在紫外线诱导的皮肤光损伤中的作用
Min Wei,Xin He,Na Liu et al.
Min Wei et al.
Reactive oxygen species (ROS), such as superoxides (O2 •-) and hydroxyl groups (OH·), are short-lived molecules containing unpaired electrons. Intracellular ROS are believed to be mainly produced by the mitochondria and NADPH oxidase (NOX...
Jiedu Fuzheng decoction improves the proliferation, migration, invasion and EMT of non-small cell lung cancer via the Wnt/β-catenin pathway [0.03%]
解毒扶正汤通过Wnt/β-连环蛋白信号通路促进非小细胞肺癌的增殖、迁移、侵袭和EMT
Fang Fang,Xiaowei Jin,Jinming Meng et al.
Fang Fang et al.
Objectives: This study aimed to investigate the effect of Jiedu Fuzheng decoction (JFD) in non-small cell lung cancer (NSCLC) and its potential therapeutic mechanism. ...
Downregulation of GDF15 suppresses ferroptosis and predicts unfavorable prognosis in clear cell renal cell carcinoma [0.03%]
GDF15下调可抑制铁死亡并预测透明细胞肾细胞癌预后不良
Dongliang Yang,Zhongyin He,Jiawei Lu et al.
Dongliang Yang et al.
Background: Growth differentiation factor 15 (GDF15), a member of the transforming growth factor beta (TGF-β) superfamily, is involved in various pathophysiological processes such as anorexia, obesity, inflammation, and ...