Long non-coding RNA NEAT1 induced by BHLHE40 activates Wnt/β-catenin signaling and potentiates colorectal cancer progression [0.03%]
BHLHE40诱导的长链非编码RNA NEAT1激活Wnt/β-catenin信号并促进结直肠癌进展
Anlong Ji,Hui Li,Xiangwei Fu et al.
Anlong Ji et al.
Background: Nuclear-enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), has been implicated in the colorectal cancer (CRC) progression. However, its upstream mechanism has not been well studied. In the ...
Frantisek Vana,Zoltan Szabo,Michal Masarik et al.
Frantisek Vana et al.
Cell death is one of the most important mechanisms of maintaining homeostasis in our body. Ferroptosis and pyroptosis are forms of necrosis-like cell death. These cell death modalities play key roles in the pathophysiology of cancer, cardio...
Depletion of NUAK2 blocks the stemness and angiogenesis and facilitates senescence of lung adenocarcinoma cells via enhancing ferroptosis [0.03%]
NUAK2耗竭通过促进铁死亡增强肺癌腺癌细胞衰老并抑制癌症干细胞特性及血管生成
Jun Fan,Lei Xue,Haoran Lin et al.
Jun Fan et al.
Background: NUAK family kinase 2 (NUAK2) has been identified as an important mediator for tumor progression in multiple malignancies. Nevertheless, its role in lung adenocarcinoma (LUAD) remains unclear. ...
NPRL2 is required for proliferation of oncogenic Ras-transformed bronchial epithelial cells [0.03%]
NPRL2是致癌性Ras转化的支气管上皮细胞增殖所必需的
Jing-Yuan Chuang,Hsiao-Hui Kuo,Pei-Han Wang et al.
Jing-Yuan Chuang et al.
Nitrogen permease regulator-like 2 (NPRL2/TUSC4) is known to exert both tumor-suppressing and oncogenic effects in different types of cancers, suggesting that its actions are context dependent. Here, we delineated the molecular and function...
Mitotic kinases are emerging therapeutic targets against metastatic breast cancer [0.03%]
有丝分裂激酶成为治疗转移性乳腺癌的潜在药物靶点
Alexandra N Aquino-Acevedo,Joel A Orengo-Orengo,Melanie E Cruz-Robles et al.
Alexandra N Aquino-Acevedo et al.
This review aims to outline mitotic kinase inhibitors' roles as potential therapeutic targets and assess their suitability as a stand-alone clinical therapy or in combination with standard treatments for advanced-stage solid tumors, includi...
Shuangyun Xi,Weijun Chen,Yong Ke
Shuangyun Xi
The silencing regulatory factor 2-like protein 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+) dependent deacetylase located primarily in the mitochondria. This protein plays an important role in oxidative stress, energy metabolism,...
Extracellular vesicle-delivered hsa_circ_0090081 regulated by EIF4A3 enhances gastric cancer tumorigenesis [0.03%]
EIF4A3调节的细胞外囊泡递送的hsa_circ_0090081促进胃癌的发生发展
Yanjie Mou,Kun Lv
Yanjie Mou
Background: Circular RNA (circRNA) and extracellular vesicles (EVs) in tumors are crucial for the malignant phenotype of tumor cells. Nevertheless, the mechanisms and clinical effects of EV-delivered hsa_circ_0090081 in g...
PPP2R2A inhibition contributes to preeclampsia by regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells [0.03%]
PPP2R2A抑制通过调节间充质干细胞的增殖、凋亡和血管生成潜能而参与子痫前期的发生发展
Yan Liu,Fangle Gu,Jun Gao et al.
Yan Liu et al.
Background: The precise mechanisms underlying preeclampsia (PE) pathogenesis remain unclear. Mesenchymal stem cells (MSCs) are involved in the pathology of PE. The aim of our study was to identify the effects of protein p...
LncRNA NUTM2A-AS1 silencing inhibits glioma via miR-376a-3p/YAP1 axis [0.03%]
长链非编码RNA NUTM2A-AS1通过miR-376a-3p/YAP1轴沉默抑制胶质瘤的发展
Yuecheng Zeng,Zhenyu Yang,Yang Yang et al.
Yuecheng Zeng et al.
The lncRNA NUTM2A-AS1 has been shown to be dysregulated in gastric cancer, while the roles in glioma is unclear. The aim of this study was to investigate the roles and potential mechanisms of lncRNA NUTM2A-AS1 in the proliferation and apopt...
GTSE1 promotes nasopharyngeal carcinoma proliferation and angiogenesis by upregulating STMN1 [0.03%]
GTSE1通过上调STMN1促进鼻咽癌增殖和血管生成
Jiadi Dong,Jingjing Chen,Yidong Wu et al.
Jiadi Dong et al.
Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor with poor survival rate. G2 and S phase-expressed-1 (GTSE1) takes part in the progression of diverse tumors as an oncogene, but its role and potential mechan...