PPP2R2A inhibition contributes to preeclampsia by regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells [0.03%]
PPP2R2A抑制通过调节间充质干细胞的增殖、凋亡和血管生成潜能而参与子痫前期的发生发展
Yan Liu,Fangle Gu,Jun Gao et al.
Yan Liu et al.
Background: The precise mechanisms underlying preeclampsia (PE) pathogenesis remain unclear. Mesenchymal stem cells (MSCs) are involved in the pathology of PE. The aim of our study was to identify the effects of protein p...
LncRNA NUTM2A-AS1 silencing inhibits glioma via miR-376a-3p/YAP1 axis [0.03%]
长链非编码RNA NUTM2A-AS1通过miR-376a-3p/YAP1轴沉默抑制胶质瘤的发展
Yuecheng Zeng,Zhenyu Yang,Yang Yang et al.
Yuecheng Zeng et al.
The lncRNA NUTM2A-AS1 has been shown to be dysregulated in gastric cancer, while the roles in glioma is unclear. The aim of this study was to investigate the roles and potential mechanisms of lncRNA NUTM2A-AS1 in the proliferation and apopt...
GTSE1 promotes nasopharyngeal carcinoma proliferation and angiogenesis by upregulating STMN1 [0.03%]
GTSE1通过上调STMN1促进鼻咽癌增殖和血管生成
Jiadi Dong,Jingjing Chen,Yidong Wu et al.
Jiadi Dong et al.
Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor with poor survival rate. G2 and S phase-expressed-1 (GTSE1) takes part in the progression of diverse tumors as an oncogene, but its role and potential mechan...
SYVN1 modulates papillary thyroid carcinoma progression by destabilizing HMGB1 [0.03%]
SYVN1通过降解HMGB1来调节乳头状甲状腺癌的进展
Fei Duan,Fanli Kong,Taifeng Jiang et al.
Fei Duan et al.
E3 ubiquitin ligase synoviolin (SYVN1) has been reported to participate in many human cancers. This study aimed to investigate SYVN1's roles and molecular pathways in papillary thyroid cancer (PTC). The functions of SYVN1 in PTC were furthe...
Cancer radioresistance is characterized by a differential lipid droplet content along the cell cycle [0.03%]
辐射抵抗型癌细胞的脂滴含量具有细胞周期依赖性变化的特征属性
Francesca Pagliari,Jeannette Jansen,Jan Knoll et al.
Francesca Pagliari et al.
Background: Cancer radiation treatments have seen substantial advancements, yet the biomolecular mechanisms underlying cancer cell radioresistance continue to elude full understanding. The effectiveness of radiation on ca...
Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia [0.03%]
克氏蛋白介导的抗氧化Nrf2/ARE信号通路激活影响低氧人滋养细胞凋亡、衰老和迁移：克氏蛋白参与子痫前期发病机制
Baomei Xu,Fang Cheng,Xiaolei Xue
Baomei Xu
The anti-aging gene Klotho is implicated in the pathogenesis of preeclampsia (PE), which is a pregnancy disease characterized by hypertension and proteinuria. Oxidative stress is closely associated with the worse outcomes in PE, and Klotho ...
lncRNA RMST is associated with the progression and prognosis of gastric cancer via miR-204-5p [0.03%]
长链非编码RNA RMST通过miR-204-5p影响胃癌进展和预后
Huimei Cai,Chenhui Li,Zhou Wu
Huimei Cai
Background: Exploring novel biomarkers for gastric cancer holds promise for enhancing patients' therapy and survival rates. lncRNAs and miRNAs have emerged as important biomarkers for various human cancers. However, the r...
Lucia Csergeová,David Krbušek,Radoslav Janoštiak
Lucia Csergeová
CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK complexes and altering their function. Initial experiments showed t...
GSDMD induces hepatocyte pyroptosis to trigger alcoholic hepatitis through modulating mitochondrial dysfunction [0.03%]
GSDMD通过调节线粒体功能障碍诱导肝细胞焦亡触发酒精性肝炎
Yandi Xie,Zilong Wang,Guangjun Song et al.
Yandi Xie et al.
Background: Mechanisms and consequences of Gasdermin D (GSDMD) activation in alcoholic hepatitis (AH) are unclear. In the present study, we investigated whether GSDMD induces hepatocyte pyroptosis by regulating mitochondr...
miR-101-3p-mediated role of PDZK1 in hepatocellular carcinoma progression and the underlying PI3K/Akt signaling mechanism [0.03%]
PDZK1在肝癌进展中的作用及microRNA-101-3p介导的PI3K/Akt信号机制
Huihui Gao,Zhaofeng Gao,Xiaobei Liu et al.
Huihui Gao et al.
Background: The molecular targets and associated mechanisms of hepatocellular carcinoma (HCC) have been widely studied, but the roles of PDZK1 in HCC are unclear. Therefore, the aim of this study is to explore the role an...