SYVN1 modulates papillary thyroid carcinoma progression by destabilizing HMGB1 [0.03%]
SYVN1通过降解HMGB1来调节乳头状甲状腺癌的进展
Fei Duan,Fanli Kong,Taifeng Jiang et al.
Fei Duan et al.
E3 ubiquitin ligase synoviolin (SYVN1) has been reported to participate in many human cancers. This study aimed to investigate SYVN1's roles and molecular pathways in papillary thyroid cancer (PTC). The functions of SYVN1 in PTC were furthe...
Cancer radioresistance is characterized by a differential lipid droplet content along the cell cycle [0.03%]
辐射抵抗型癌细胞的脂滴含量具有细胞周期依赖性变化的特征属性
Francesca Pagliari,Jeannette Jansen,Jan Knoll et al.
Francesca Pagliari et al.
Background: Cancer radiation treatments have seen substantial advancements, yet the biomolecular mechanisms underlying cancer cell radioresistance continue to elude full understanding. The effectiveness of radiation on ca...
Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia [0.03%]
克氏蛋白介导的抗氧化Nrf2/ARE信号通路激活影响低氧人滋养细胞凋亡、衰老和迁移：克氏蛋白参与子痫前期发病机制
Baomei Xu,Fang Cheng,Xiaolei Xue
Baomei Xu
The anti-aging gene Klotho is implicated in the pathogenesis of preeclampsia (PE), which is a pregnancy disease characterized by hypertension and proteinuria. Oxidative stress is closely associated with the worse outcomes in PE, and Klotho ...
lncRNA RMST is associated with the progression and prognosis of gastric cancer via miR-204-5p [0.03%]
长链非编码RNA RMST通过miR-204-5p影响胃癌进展和预后
Huimei Cai,Chenhui Li,Zhou Wu
Huimei Cai
Background: Exploring novel biomarkers for gastric cancer holds promise for enhancing patients' therapy and survival rates. lncRNAs and miRNAs have emerged as important biomarkers for various human cancers. However, the r...
Lucia Csergeová,David Krbušek,Radoslav Janoštiak
Lucia Csergeová
CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK complexes and altering their function. Initial experiments showed t...
GSDMD induces hepatocyte pyroptosis to trigger alcoholic hepatitis through modulating mitochondrial dysfunction [0.03%]
GSDMD通过调节线粒体功能障碍诱导肝细胞焦亡触发酒精性肝炎
Yandi Xie,Zilong Wang,Guangjun Song et al.
Yandi Xie et al.
Background: Mechanisms and consequences of Gasdermin D (GSDMD) activation in alcoholic hepatitis (AH) are unclear. In the present study, we investigated whether GSDMD induces hepatocyte pyroptosis by regulating mitochondr...
miR-101-3p-mediated role of PDZK1 in hepatocellular carcinoma progression and the underlying PI3K/Akt signaling mechanism [0.03%]
PDZK1在肝癌进展中的作用及microRNA-101-3p介导的PI3K/Akt信号机制
Huihui Gao,Zhaofeng Gao,Xiaobei Liu et al.
Huihui Gao et al.
Background: The molecular targets and associated mechanisms of hepatocellular carcinoma (HCC) have been widely studied, but the roles of PDZK1 in HCC are unclear. Therefore, the aim of this study is to explore the role an...
Zinc finger protein 468 up-regulation of TFAM contributes to the malignant growth and cisplatin resistance of breast cancer cells [0.03%]
锌指蛋白468通过上调TFAM促进乳腺癌细胞的恶性增殖和顺铂抗性
Zhaoyang Jia,Feng Wang,Gongzhuo Li et al.
Zhaoyang Jia et al.
Background: Because of the progress on the diagnosis and treatment for patients with breast cancer (BC), the overall survival of the patients has been improved. However, a number of BC patients cannot benefit from the exi...
Ultrasonic microbubbles promote mesenchymal stem cell homing to the fibrotic liver via upregulation of CXCR4 expression [0.03%]
超声微气泡通过上调CXCR4表达促进间充质干细胞归巢至肝纤维化部位
Heming Xu,Yize Huang,Fasu Zhang et al.
Heming Xu et al.
Objective: To investigate the mechanism of ultrasound microbubbles (UTMB) promoting stem cells homing to fibrotic liver. Methods: Bone ...
Anti-cancer effects of Coix seed extract through KCTD9-mediated ubiquitination of TOP2A in lung adenocarcinoma [0.03%]
薏苡仁提取物通过KCTD9介导的TOP2A泛素化产生抗癌效果的研究
Jiuyang Jiang,Xue Li,Chun Zhang et al.
Jiuyang Jiang et al.
Background: Coix seed extract (CSE), a traditional Chinese medicine, has been reported as an adjunctive therapy in cancers. However, the molecular targets are largely unclear. The study is designed to unveil its function ...