LncRNA-ANRIL regulates CDKN2A to promote malignant proliferation of Kasumi-1 cells [0.03%]
长链非编码RNA-ANRIL通过调节CDKN2A促进Kasumi-1细胞恶性增殖的作用及机制研究
Jianxia Xu,Jingxin Zhang,Chengsi Zhang et al.
Jianxia Xu et al.
Objective: This study aimed to investigate the regulatory effects of long non-coding RNA-ANRIL on CDKN2A in the cell cycle of Kasumi-1 cells and elucidate the underlying molecular mechanisms. ...
Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development [0.03%]
STIL与FOXM1相互作用调控肝癌发生发展的SF3A3转录机制研究
Haijun Zhang,Lin Zhang,Ziqi Wu
Haijun Zhang
Background: Dysregulation of SF3A3 has been related to the development of many cancers. Here, we investigated the functional role of SF3A3 in hepatocellular carcinoma (HCC). ...
PP2A-Tws dephosphorylates Map205, is required for Polo localization to microtubules and promotes cytokinesis in Drosophila [0.03%]
Drosophila PP2A-Tws通过去磷酸化Map205控制Polo的微管定位及有丝分裂后期-末期转换顺利进行
Marine Guelle,Virginie Emond-Fraser,Vincent Archambault
Marine Guelle
Background: Mitosis and cytokinesis are regulated by reversible phosphorylation events controlled by kinases and phosphatases. Drosophila Polo kinase, like its human ortholog PLK1, plays several roles in this process. Mul...
STEAP4 with copper reductase activity suppresses tumorigenesis by regulating the cell cycle in hepatocellular carcinoma cells [0.03%]
具有铜还原酶活性的STEAP4通过调节肝癌细胞周期抑制肿瘤发生
Ting Yang,Minhong Zou,Yujie Xie et al.
Ting Yang et al.
Background: Abnormal expression of six-transmembrane epithelial antigen of prostate 4 (STEAP4) has been implicated in the carcinogenesis of hepatocellular carcinoma (HCC). However, the biological role and regulatory mecha...
ZEB2 reduction contributes to pre-eclampsia via Wnt/β-Catenin pathway [0.03%]
ZEB2下调通过Wnt/β-catenin信号转导途径促进子痫前期发病
Yanxin Zhang,Fangle Gu,Yan Liu et al.
Yanxin Zhang et al.
Background: Pre-eclampsia (PE) is a pregnancy specific disease characterized by hypertension and proteinuria. The aim of this study was to investigate the effects of Zinc finger E-box binding homologous box 2 (ZEB2) on PE...
Curcumin enhances ATG3-dependent autophagy and inhibits metastasis in cervical carcinoma [0.03%]
姜黄素通过增强自噬抑制宫颈癌的转移
Fei Zheng,Jingjing Lu,Chuhan Wang et al.
Fei Zheng et al.
Cervical carcinoma poses a significant health threat, with traditional treatments proving inadequate in advanced stages. Curcumin, a bioactive compound derived from turmeric, exhibits notable anti-inflammatory, antioxidant, and antineoplast...
The E3 ubiquitin ligase RNF6 facilitates the progression of cervical cancer by inhibiting the Hippo/Yap pathway [0.03%]
E3泛素连接酶RNF6通过抑制Hippo/Yap通路促进宫颈癌进展
Yawen Liu,Juanjuan Zhou,Weiqi Liu et al.
Yawen Liu et al.
Purpose: Cervical cancer (CC), a significant global health threat, necessitates comprehensive understanding for improved therapeutic interventions. Many research indicates that dysregulation of the Hippo-YAP1 pathway lead...
ZSCAN16 expedites hepatocellular carcinoma progression via activating TBC1D31 [0.03%]
ZSCAN16通过激活TBC1D31促进肝细胞癌进展
Xiaofang Wang,Bo Xiao,Fuping Zhong et al.
Xiaofang Wang et al.
Objective: Hepatocellular carcinoma (HCC) is fatal and poses great challenges to early diagnosis and effective treatment. This paper sought to expound the function of Zinc finger and SCAN domain-containing protein 16 (ZSC...
miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1 [0.03%]
microRNA-miR-3154通过靶向TP53INP1促进胶质母细胞瘤的增殖和转移
Xiangdan Lin,Qiong Wu,Wei Lei et al.
Xiangdan Lin et al.
Glioblastomas (GBM) are most common types of primary brain tumors and miRNAs play an important role in pathogenesis of glioblastomas. Here, we reported a new miRNA, miR-3154, which regulates glioblastoma proliferation and metastasis. miR-31...
MiR-5195-3p predicts clinical prognosis and represses colorectal cancer progression by targeting TLR4/MyD88 signaling [0.03%]
microRNA-5195-3p通过靶向TLR4/MyD88信号轴预测结直肠癌预后并抑制结直肠癌进展
Yandong Lv,Shuwei Guo,Lingtong Jin et al.
Yandong Lv et al.
Background: Recent studies have highlighted the role of miR-5195-3p in suppressing cell growth in various cancers. However, the specific functional impact of miR-5195-3p in colorectal cancer (CRC) remain to be fully clari...