METTL16 accelerates lung adenocarcinoma progression by inducing N6-methyladenosine modification of GTSE1 to regulate p53 pathway and cell cycle [0.03%]
METTL16通过诱导GTSE1的N6-甲基腺苷修饰来调节p53通路和细胞周期从而促进肺腺癌进展
Fang Liu,Sheng Jin
Fang Liu
Background: METTL16 has recently emerged as an N6-methyladenosine (m6A) methyltransferase that serves an integral role in tumor regulation. However, its involvement in lung adenocarcinoma (LUAD) remains unexamined. This i...
Role of HSF1 in cell division, tumorigenesis and therapy: a literature review [0.03%]
HSF1在细胞分裂、肿瘤发生及治疗中的作用：文献综述
Otakar Fiser,Petr Muller
Otakar Fiser
Heat shock factor 1 (HSF1) is the master orchestrator of the heat shock response (HSR), a critical process for maintaining cellular health and protein homeostasis. These effects are achieved through rapid expression of molecular chaperones,...
The m6A modification of LncRNA LINC00200 regulated by WTAP accelerates glioma tumorigenesis by regulating Wnt/β-catenin pathway [0.03%]
WTAP介导的LINC00200m6A修饰通过调节Wnt/β-catenin信号通路促进胶质瘤发生发展
Zhiying Lu,Jing Chen,Chao Luo
Zhiying Lu
Background: Several studies have delineated that dysregulated N6-methyladenosine (m6A) regulators participate in glioma progression. The objective of this study is to investigate the mechanism of Wilms' tumor 1-associatin...
METTL16/IGF2BP2 axis enhances malignant progression and DDP resistance through up-regulating COL4A1 by mediating the m6A methylation modification of LAMA4 in hepatocellular carcinoma [0.03%]
METTL16/IGF2BP2轴通过介导LAMA4的m6A甲基化修饰来上调COL4A1，从而增强肝癌恶性进展和顺铂耐药性
Liming Cao,Wei Bi
Liming Cao
Background: Hepatocellular carcinoma (HCC) is the third most common malignant tumor after gastric cancer and esophageal cancer, which is a serious threat to human health. Methyltransferase-like protein 16 (METTL16) regula...
YAP1 activates SLC2A1 transcription and augments the malignant behavior of colorectal cancer cells by activating the Wnt/β-catenin signaling pathway [0.03%]
YAP1通过激活Wnt/β-连环蛋白信号通路转录活化SLC2A1并增强结直肠癌细胞恶性行为
Kunpeng Li,Ya-Jie Dai,Haifeng Zhang et al.
Kunpeng Li et al.
Objective: This paper examined the role of solute carrier family 2 member 1 (SLC2A1) in colorectal cancer (CRC) progression, focusing on its expression levels, functional implications, and regulatory mechanisms involving ...
RFX2 downregulates RASSF1 expression and YAP phosphorylation through Hippo signaling to promote immune escape in lung adenocarcinoma [0.03%]
RFX2通过Hippo信号下调RASSF1表达和YAP磷酸化以促进肺腺癌免疫逃逸
Zhenzhen Kong,Ping Zhou,Jiahao Xu et al.
Zhenzhen Kong et al.
Objective: Regulatory Factor X (RFX) transcription factors have been implicated in different cancers. Ras association domain family (RASSF) has been shown clinical significance in lung cancer. This paper was to investigat...
The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells [0.03%]
微小核糖核酸在间充质干细胞向血管平滑肌细胞分化中的作用
Sakhavat Abolhasani,Yasin Ahmadi,Yavar Rostami et al.
Sakhavat Abolhasani et al.
MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a vital role in regulating gene expression, especially in the differentiation of mesenchymal stem cells (MSCs) into vascular smooth muscle cells (VSMCs). MSCs hold considerable...
Maraviroc enhances Bortezomib sensitivity in multiple myeloma by inhibiting M2 macrophage polarization via PI3K/AKT/RhoA signaling pathway in macrophages [0.03%]
马夫罗西克通过巨噬细胞中的PI3K/AKT/RhoA信号通路抑制M2型巨噬细胞极化，提高波蛋白酶对多发性骨髓瘤的敏感性
Huiye Yang,Yuchan He,Fujun Qu et al.
Huiye Yang et al.
Background: Multiple myeloma (MM) is a malignancy where drug resistance often leads to relapse or refractory disease. Chemokine receptor 5 (CCR5) has emerged as a novel therapeutic target. However, the role of CCR5-antago...
Tereza Růžičková,Monika Vlachová,Lukáš Pečinka et al.
Tereza Růžičková et al.
Background: Multiple myeloma (MM) represents the second most common hematological malignancy characterized by the infiltration of the bone marrow by plasma cells that produce monoclonal immunoglobulin. While the quality a...
Wen Luo,Qiyu Xiao,Ying Fu
Wen Luo
Background: Zinc finger protein 169 (ZNF169) plays a key role in cancer development. However, the specific role of ZNF169 in the tumorigenesis of thyroid carcinoma (THCA) remains poorly understood. ...