Restriction beyond the restriction point: mitogen requirement for G2 passage [0.03%]
限制点后的限制：有丝分裂原对G2期进程的要求
Floris Foijer,Hein Te Riele
Floris Foijer
Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G1 restriction point, resulting in cell cycle arrest. Passage through the G1 restriction point involves inactivation of the retinoblastoma pr...
Mike Boxem
Mike Boxem
Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell-cycle machinery has been identified, and a...
Modification of Cul1 regulates its association with proteasomal subunits [0.03%]
Cul1的修饰调控其与蛋白酶体亚基的相互作用
Joanna Bloom,Angelo Peschiaroli,George Demartino et al.
Joanna Bloom et al.
Background: Ubiquitylation targets proteins for degradation by the 26S proteasome. Some yeast and plant ubiquitin ligases, including the highly conserved SCF (Skp1/Cul1/F-box protein) complex, have been shown to associate...
Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice [0.03%]
Skp2缺陷小鼠由于细胞周期进程受损导致的生殖细胞发育障碍
Abbas Fotovati,Keiko Nakayama,Keiichi I Nakayama
Abbas Fotovati
Background: The gonads are responsible for the production of germ cells through both mitosis and meiosis. Skp2 is the receptor subunit of an SCF-type ubiquitin ligase and is a major regulator of the progression of cells i...
Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae [0.03%]
Rim15及酿酒酵母营养信号途径的汇合点
Erwin Swinnen,Valeria Wanke,Johnny Roosen et al.
Erwin Swinnen et al.
In recent years, the general understanding of nutrient sensing and signalling, as well as the knowledge about responses triggered by altered nutrient availability have greatly advanced. While initial studies were directed to top-down elucid...