The spindle position checkpoint in budding yeast: the motherly care of MEN [0.03%]
酿酒酵母中的芽殖检查点：MEN的呵护作用
Simonetta Piatti,Marianna Venturetti,Elena Chiroli et al.
Simonetta Piatti et al.
Mitotic exit and cytokinesis must be tightly coupled to nuclear division both in time and space in order to preserve genome stability and to ensure that daughter cells inherit the right set of chromosomes after cell division. This is achiev...
Cyril Berthet,Philipp Kaldis
Cyril Berthet
Progression through the mammalian cell cycle is associated with the activity of four cyclin dependent kinases (Cdc2/Cdk1, Cdk2, Cdk4, and Cdk6). Knockout mouse models have provided insight into the interplay of these Cdks. Most of these mod...
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A [0.03%]
姐妹染色单体着丝点连接的阴阳性：有丝分裂激酶遇见蛋白磷酸酶2A
Wei Dai,Xiaoxing Wang
Wei Dai
Accurate chromosome segregation during meiosis and mitosis is essential for the maintenance of genomic stability. Defects in the regulation of chromosome segregation during division predispose cells to undergo mitotic catastrophe or neoplas...
Restriction beyond the restriction point: mitogen requirement for G2 passage [0.03%]
限制点后的限制：有丝分裂原对G2期进程的要求
Floris Foijer,Hein Te Riele
Floris Foijer
Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G1 restriction point, resulting in cell cycle arrest. Passage through the G1 restriction point involves inactivation of the retinoblastoma pr...
Mike Boxem
Mike Boxem
Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell-cycle machinery has been identified, and a...
Modification of Cul1 regulates its association with proteasomal subunits [0.03%]
Cul1的修饰调控其与蛋白酶体亚基的相互作用
Joanna Bloom,Angelo Peschiaroli,George Demartino et al.
Joanna Bloom et al.
Background: Ubiquitylation targets proteins for degradation by the 26S proteasome. Some yeast and plant ubiquitin ligases, including the highly conserved SCF (Skp1/Cul1/F-box protein) complex, have been shown to associate...
Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice [0.03%]
Skp2缺陷小鼠由于细胞周期进程受损导致的生殖细胞发育障碍
Abbas Fotovati,Keiko Nakayama,Keiichi I Nakayama
Abbas Fotovati
Background: The gonads are responsible for the production of germ cells through both mitosis and meiosis. Skp2 is the receptor subunit of an SCF-type ubiquitin ligase and is a major regulator of the progression of cells i...
Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae [0.03%]
Rim15及酿酒酵母营养信号途径的汇合点
Erwin Swinnen,Valeria Wanke,Johnny Roosen et al.
Erwin Swinnen et al.
In recent years, the general understanding of nutrient sensing and signalling, as well as the knowledge about responses triggered by altered nutrient availability have greatly advanced. While initial studies were directed to top-down elucid...