Tomás Aparicio,Arkaitz Ibarra,Juan Méndez
Tomás Aparicio
The identity of the DNA helicase(s) involved in eukaryotic DNA replication is still a matter of debate, but the mini-chromosome maintenance (MCM) proteins are the chief candidate. Six conserved MCM proteins, Mcm2-7, are essential for the in...
E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression [0.03%]
E2F1激活导致HMGA2基因过度表达诱导的垂体腺瘤
Monica Fedele,Giovanna Maria Pierantoni,Rosa Visone et al.
Monica Fedele et al.
The High Mobility Group protein HMGA2 is a nuclear architectural factor that plays a critical role in a wide range of biological processes including regulation of gene expression, embryogenesis and neoplastic transformation. Several studies...
The yeast ubiquitin ligase SCFMet30: connecting environmental and intracellular conditions to cell division [0.03%]
酵母泛素连接酶SCFMet30：连接环境和细胞内条件与细胞分裂之间的关系
Peter Kaiser,Ning-Yuan Su,James L Yen et al.
Peter Kaiser et al.
Ubiquitination regulates a host of cellular processes and is well known for its role in progression through the cell division cycle. In budding yeast, cadmium and arsenic stress, the availability of sulfur containing amino acids, and the in...
Karen E Knudsen
Karen E Knudsen
The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (C...
Qian Dai,Hengbin Wang
Qian Dai
Cullin 4 (Cul4), a member of the evolutionally conserved cullin protein family, serves as a scaffold to assemble multisubunit ubiquitin E3 ligase complexes. Cul4 interacts with the Ring finger-containing protein ROC1 through its C-terminal ...
Guillaume Bossis,Frauke Melchior
Guillaume Bossis
Post-translational modifiers of the SUMO (Small Ubiquitin-related Modifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates...
Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes [0.03%]
联体双胞胎的分离：Cdk1、Cdh1和中心体分离
Karen Crasta,Uttam Surana
Karen Crasta
Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity...
Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region [0.03%]
Akt1连续磷酸化p27kip1保守但非典型区域内的氨基酸残基
Lucas P Nacusi,Robert J Sheaff
Lucas P Nacusi
Background: p27kip1 (p27) is a multifunctional protein implicated in regulation of cell cycling, signal transduction, and adhesion. Its activity is controlled in part by Phosphatylinositol-3-Kinase (PI3K)/Akt1 signaling, ...
"ATR activation in response to ionizing radiation: still ATM territory" [0.03%]
离子化辐射诱导的ATR活化依然由ATM调控
Myriam Cuadrado,Barbara Martinez-Pastor,Oscar Fernandez-Capetillo
Myriam Cuadrado
Unrepaired DNA double-strand breaks (DSBs) are a major cause for genomic instability. Therefore, upon detection of a DSB a rapid response must be assembled to coordinate the proper repair/signaling of the lesion or the elimination of cells ...
Cell Division, a new open access online forum for and from the cell cycle community [0.03%]
细胞分裂——一个新的开放获取论坛为和来自细胞周期研究领域的社区
Philipp Kaldis,Michele Pagano
Philipp Kaldis
Cell Division is a new, open access, peer-reviewed online journal that publishes cutting-edge articles, commentaries and reviews on all exciting aspects of cell cycle control in eukaryotes. A major goal of this new journal is to publish tim...