Yeast UBL-UBA proteins have partially redundant functions in cell cycle control [0.03%]
酵母UBL-UBA蛋白在细胞周期控制中的部分冗余功能
Laura A Díaz-Martínez,Yang Kang,Kylie J Walters et al.
Laura A Díaz-Martínez et al.
Background: Proteins containing ubiquitin-like (UBL) and ubiquitin associated (UBA) domains have been suggested to shuttle ubiquitinated substrates to the proteasome for degradation. There are three UBL-UBA containing pro...
The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast [0.03%]
酿酒酵母CENP-B同源物Abp1与起始蛋白Cdc23（MCM10）相互作用并在高效DNA复制中是必需的
Alexandra M Locovei,Maria-Grazia Spiga,Katsunori Tanaka et al.
Alexandra M Locovei et al.
Abp1, and the closely related Cbh1 and Cbh2 are homologous to the human centromere-binding protein CENP-B that has been implicated in the assembly of centromeric heterochromatin. Fission yeast cells lacking Abp1 show an increase in mini-chr...
Vlastimil Srsen,Andreas Merdes
Vlastimil Srsen
Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification...
Regulation of CDK4 [0.03%]
CDK4的调控
Laurence Bockstaele,Katia Coulonval,Hugues Kooken et al.
Laurence Bockstaele et al.
Cyclin-dependent kinase (CDK)4 is a master integrator that couples mitogenic and antimitogenic extracellular signals with the cell cycle. It is also crucial for many oncogenic transformation processes. In this overview, we address various m...
Andriy Marusyk,James DeGregori
Andriy Marusyk
The 2006 Cold Spring Harbor Laboratory meeting on the Mechanisms and Models of Cancer was held August 16-20. The meeting featured several hundred presentations of many short talks (mostly selected from the abstracts) and posters, with the a...
Paradoxical expression of INK4c in proliferative multiple myeloma tumors: bi-allelic deletion vs increased expression [0.03%]
增生性多发性骨髓瘤肿瘤中INK4c的矛盾表达：双等位基因缺失与高表达
Amel Dib,Timothy R Peterson,Laura Raducha-Grace et al.
Amel Dib et al.
Background: A high proliferative capacity of tumor cells usually is associated with shortened patient survival. Disruption of the RB pathway, which is critically involved in regulating the G1 to S cell cycle transition, i...
Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells [0.03%]
CDT1重访：细胞周期中的复杂而严格的调控及其在哺乳动物细胞中失衡的后果
Masatoshi Fujita
Masatoshi Fujita
In eukaryotic cells, replication of genomic DNA initiates from multiple replication origins distributed on multiple chromosomes. To ensure that each origin is activated precisely only once during each S phase, a system has evolved which fea...
Tom A M Groothuis,Nico P Dantuma,Jacques Neefjes et al.
Tom A M Groothuis et al.
The polypeptide ubiquitin is used in many processes as different as endocytosis, multivesicular body formation, and regulation of gene transcription. Conjugation of a single ubiquitin moiety is typically used in these processes. A polymer o...
FAT10, a gene up-regulated in various cancers, is cell-cycle regulated [0.03%]
FAT10基因在多种癌症中表达上调并与细胞周期相关
Chuan-Bian Lim,Dongwei Zhang,Caroline G L Lee
Chuan-Bian Lim
Background: FAT10 is a member of the ubiquitin-like-modifier family of proteins. Over-expression of the FAT10 gene was observed in the tumors of several epithelial cancers. High FAT10 expression was found to lead to incre...
Tying the loose ends together in DNA double strand break repair with 53BP1 [0.03%]
53BP1在DNA双链断裂修复中的作用机制研究进展
Melissa M Adams,Phillip B Carpenter
Melissa M Adams
To maintain genomic stability and ensure the fidelity of chromosomal transmission, cells respond to various forms of genotoxic stress, including DNA double-stranded breaks (DSBs), through the activation of DNA damage response signaling netw...