Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling? [0.03%]
Stat3:炎症与上皮癌的关系-不仅仅是“肠道”的感觉？
Andrew Jarnicki,Tracy Putoczki,Matthias Ernst
Andrew Jarnicki
Inflammation is an important environmental factor that promotes tumourigenesis and the progression of established cancerous lesions, and recent studies have started to dissect the mechanisms linking the two pathologies. These inflammatory a...
Merotelic attachments and non-homologous end joining are the basis of chromosomal instability [0.03%]
染色体不稳定的基因为异源连接和非同源末端连接
Astrid Alonso Guerrero,Carlos Martínez-A,Karel Hm van Wely
Astrid Alonso Guerrero
Although the large majority of solid tumors show a combination of mitotic spindle defects and chromosomal instability, little is known about the mechanisms that govern the initial steps in tumorigenesis. The recent report of spindle-induced...
Editorial
Cell division. 2010 May 17:5:13. DOI:10.1186/1747-1028-5-13 2010
Greg H Enders
Greg H Enders
The kinase Wee1 has been recognized for a quarter century as a key inhibitor of Cyclin dependent kinase 1 (Cdk1) and mitotic entry in eukaryotes. Nonetheless, Wee1 regulation is not well understood and its large amino-terminal regulatory do...
Editorial
Cell division. 2010 May 13:5:12. DOI:10.1186/1747-1028-5-12 2010
Jorrit M Enserink,Richard D Kolodner
Jorrit M Enserink
The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the model organism S. cerevisiae. Research performed during the past decade has significantly improved our understanding of the molecular machinery of the...
Expression of human eukaryotic initiation factor 3f oscillates with cell cycle in A549 cells and is essential for cell viability [0.03%]
人源性的真核起始因子3F在A549细胞中的表达随细胞周期波动并且对维持细胞活力至关重要
Ana E Higareda-Mendoza,Marco A Pardo-Galván
Ana E Higareda-Mendoza
Background: Transcriptional and postranslational regulation of the cell cycle has been widely studied. However, there is scarce knowledge concerning translational control of this process. Several mammalian eukaryotic init...
Stacey E Wirt,Julien Sage
Stacey E Wirt
p107 and its related family members Rb and p130 are critical regulators of cellular proliferation and tumorigenesis. Due to the extent of functional overlap within the Rb family, it has been difficult to assess which functions are exclusive...
The replication stress response and the ubiquitin system: a new link in maintaining genomic integrity [0.03%]
复制压力响应与泛素系统：保持基因组完整性的新联系
Deanna M Koepp
Deanna M Koepp
Maintenance of genomic integrity is important for cellular viability and proliferation. During DNA replication, cells respond to replication stress by activating checkpoint pathways that stabilize replication forks and prevent cell cycle pr...
Editorial
Cell division. 2010 Mar 10:5:8. DOI:10.1186/1747-1028-5-8 2010
Richa Singh,Jasmine George,Yogeshwer Shukla
Richa Singh
Senescence and mitotic catastrophe (MC) are two distinct crucial non-apoptotic mechanisms, often triggered in cancer cells and tissues in response to anti-cancer drugs. Chemotherapeuticals and myriad other factors induce cell eradication vi...
Srilata Bagchi,Pradip Raychaudhuri
Srilata Bagchi
Apoptosis induced by DNA damage is an important mechanism of tumor suppression and it is significant also in cancer chemotherapy. Mammalian cells activate the pathways of p53 to induce apoptosis of cells harboring irreparable DNA damages. W...
Lluis Fajas,Emilie Blanchet,Jean-Sébastien Annicotte
Lluis Fajas
Pancreatic beta-cells are metabolic sensors involved in the control of glucose homeostasis. This particular cell type controls insulin secretion through a fine-tuned process, which dregulation have important pathological consequences, such ...
Editorial
Cell division. 2010 Feb 5;5(1):6. DOI:10.1186/1747-1028-5-6 2010