On the traces of XPD: cell cycle matters - untangling the genotype-phenotype relationship of XPD mutations [0.03%]
沿着XPD的轨迹：细胞周期很重要——解开XPD突变的基因型-表型关系
Elisabetta Cameroni,Karin Stettler,Beat Suter
Elisabetta Cameroni
Mutations in the human gene coding for XPD lead to segmental progeria - the premature appearance of some of the phenotypes normally associated with aging - which may or may not be accompanied by increased cancer incidence. XPD is required f...
Jonathan A Robbins,Frederick R Cross
Jonathan A Robbins
Background: Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of critical cell-cycle-regulatory targets including secu...
The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation [0.03%]
WW-HECT蛋白Smurf2与衔接蛋白NEDD9/HEF1相互作用激活Aurora A蛋白质
Finola E Moore,Evan C Osmundson,Jennifer Koblinski et al.
Finola E Moore et al.
The multi-functional adaptor protein NEDD9/HEF1/Cas-L regulates cell motility, invasion and cell cycle progression, and plays key roles in cancer progression and metastasis. NEDD9 is localized to the centrosome and is required for activatio...
Mark Meuth
Mark Meuth
The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This rev...
A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe [0.03%]
裂殖酵母染色体复制缺陷(rid)突变的遗传筛选研究
Alexandra M Locovei,Ling Yin,Gennaro D&#x;Urso
Alexandra M Locovei
In fission yeast the intra-S phase and DNA damage checkpoints are activated in response to inhibition of DNA replication or DNA damage, respectively. The intra-S phase checkpoint responds to stalled replication forks leading to the activati...
Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine [0.03%]
单泛素化和多泛素链形成的机制：临近赖氨酸的氨基酸残基与E2催化核心的匹配决定泛素化的特异性
Martin Sadowski,Boris Sarcevic
Martin Sadowski
Ubiquitination involves the attachment of ubiquitin to lysine residues on substrate proteins or itself, which can result in protein monoubiquitination or polyubiquitination. Ubiquitin attachment to different lysine residues can generate div...
Editorial
Cell division. 2010 Aug 13:5:19. DOI:10.1186/1747-1028-5-19 2010
Coupling histone homeostasis to centromere integrity via the ubiquitin-proteasome system [0.03%]
泛素-蛋白酶体系统介导组蛋白稳态与着丝粒稳定相耦联
Yuko Takayama,Takashi Toda
Yuko Takayama
In many eukaryotes, histone gene expression is regulated in a cell cycle-dependent manner, with a spike pattern at S phase. In fission yeast the GATA-type transcription factor Ams2 is required for transcriptional activation of all the core ...
Editorial
Cell division. 2010 Jul 7:5:18. DOI:10.1186/1747-1028-5-18 2010
A software solution for recording circadian oscillator features in time-lapse live cell microscopy [0.03%]
一种用于在长时间活细胞显微镜检查中记录昼夜振荡器特征的软件解决方案
Daniel Sage,Michael Unser,Patrick Salmon et al.
Daniel Sage et al.
Background: Fluorescent and bioluminescent time-lapse microscopy approaches have been successfully used to investigate molecular mechanisms underlying the mammalian circadian oscillator at the single cell level. However, ...
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci [0.03%]
衰老的小鼠细胞未能明显调节HIRA组蛋白伴侣且未形成牢固的异染色质 focus 现象
Alyssa L Kennedy,Tony McBryan,Greg H Enders et al.
Alyssa L Kennedy et al.
Background: Cellular senescence is a permanent growth arrest that occurs in response to cellular stressors, such as telomere shortening or activation of oncogenes. Although the process of senescence growth arrest is somew...
Alexander V Strunnikov
Alexander V Strunnikov
Recent data show that cells from many cancers exhibit massive chromosome instability. The traditional view is that the gradual accumulation of mutations in genes involved in transcriptional regulation and cell cycle controls results in tumo...