IL-8 drives EMT and malignant progression in chronic obstructive pulmonary disease-associated lung cancer via STAT3 signaling [0.03%]
IL-8通过STAT3信号转导驱动慢性阻塞性肺疾病相关肺癌的上皮间质转化及恶性进展
Xin Zhou,Rong Yao,Yuanyuan Dong et al.
Xin Zhou et al.
The TMPO-AS1/hsa-let-7b-5p regulatory axis shapes transcriptional heterogeneity and immune landscape in lung adenocarcinoma [0.03%]
TMPO-AS1/hsa-let-7b-5p调控轴形塑肺腺癌转录异质性和免疫图谱
Sakshi Nirmal,Chainsee Saini,Bhavika Baweja et al.
Sakshi Nirmal et al.
Background: Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy with poor clinical outcomes, underscoring the urgent need for robust prognostic biomarkers and therapeutically tractable regulatory molecules. Lo...
PRRX2-CNTN3 axis promotes epithelial-to-mesenchymal transition and metastasis in colorectal cancer [0.03%]
PRRX2-CNTN3轴促进结直肠癌上皮间质转化及转移
Song Yu,Ji Li,Shaolin Li
Song Yu
Objective: The study investigates the role of CNTN3 in colorectal cancer (CRC) progression and its transcriptional regulation by PRRX2, exploring their potential contributions to epithelial-to-mesenchymal transition (EMT)...
SOCS3 suppresses glioblastoma growth via JAK-STAT inhibition and mitochondrial unfolded protein response activation [0.03%]
SOCS3通过抑制JAK-STAT和激活线粒体未折叠蛋白反应抑制胶质母细胞瘤生长
Gaolei Hou,Zhaofei Song,Jingtao Wang et al.
Gaolei Hou et al.
Introduction: Glioblastoma (GBM) represents one of the most aggressive brain malignancies, characterized by rapid proliferation and pronounced resistance to apoptosis, resulting in poor therapeutic outcomes. Suppressor of...
The roles and pathways of Hsa_circ_0000285 in cancer: a potential target for cancer therapy [0.03%]
Hsa_circ_0000285在癌症中的作用和途径：癌症治疗的潜在靶点
Yan Lv,Dan Li,Qun-Xian Zhang et al.
Yan Lv et al.
Circular RNA (circRNA) is a unique type of non-coding RNA molecule characterized by a closed circular structure, exceptional stability, and the ability to act as miRNA sponges, thereby relieving their inhibitory effects on downstream target...
Research progress on vasculogenic mimicry in colorectal cancer: mechanisms and therapeutic [0.03%]
血管生成拟态在结直肠癌中的研究进展：机制及治疗策略
Jian Zewei,Zhao Haiyan
Jian Zewei
Colorectal cancer (CRC) is the third most common malignant tumor worldwide and is characterized by high incidence and mortality rates. In the chemotherapeutic treatment of CRC, antiangiogenic therapy is utilized throughout the entire diseas...
MiR-124-3p inhibits stomach adenocarcinoma progression by targeting AHR to induce autophagy [0.03%]
miR-124-3p通过靶向AHR诱导自噬从而抑制胃腺癌进展
Qian Wan,Siwei Wang,Wei Dong et al.
Qian Wan et al.
Background: MicroRNA-124-3p (miR-124-3p) has been widely reported as an important tumor-suppressive regulator in multiple malignancies. Nevertheless, its precise biological function in stomach adenocarcinoma (STAD) remain...
FOXP3-activated KCNMB2-AS1 promotes clear cell renal cell carcinoma through the miR-744-3p/CD1D axis [0.03%]
FOXP3活化的KCNMB2-AS1通过miR-744-3p/CD1D轴促进透明细胞肾细胞癌
Geng Huang,Dingwen Gui,Yankuang Guo et al.
Geng Huang et al.
Background: Long noncoding RNAs (lncRNAs) are key regulators in cancer progression. Among them, KCNMB2 antisense RNA 1 (KCNMB2-AS1) has been identified as an oncogenic lncRNA in several tumor types; however, its role in c...
Role of LINC00332 in colorectal cancer progression and paclitaxel resistance [0.03%]
LINC00332在结直肠癌进展和紫杉醇耐药中的作用
Meysam Moghbeli,Negin Taghehchian,Mahsa Palizkaran Yazdi et al.
Meysam Moghbeli et al.
Background: Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer deaths. Standard therapeutic management is faced with challenges like treatment resistance and late-stage diagnosis, highli...
hsa-let-7b-5p-associated BUB1/TMPO-AS1 ceRNA axis identified as a potential biomarker in lung adenocarcinoma [0.03%]
基于ceRNA的hsa-let-7b-5p相关BUB1 / TMPO-AS1轴可作为肺腺癌潜在生物标志物
Bhavika Baweja,Prerna Vats,Chainsee Saini et al.
Bhavika Baweja et al.
Objective: BUB1, a key mitotic checkpoint kinase, is often dysregulated in cancer, yet its regulatory mechanism remains unclear. This study investigates the BUB1-centered miRNA-lncRNA-mRNA (ceRNA) network, its role in cel...