Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells [0.03%]
Her2阳性乳腺癌细胞与非致瘤性MCF10A细胞中中心体调节蛋白的差异表达
Mi-Young Lee,Mihaela Marina,Jamie L King et al.
Mi-Young Lee et al.
Centrosome amplification (CA) amongst particular breast cancer subtypes (Her2+ subtype) is associated with genomic instability and aggressive tumor phenotypes. However, changes in signaling pathways associated with centrosome biology have n...
Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner [0.03%]
CNKSR2依赖的Smurf2泛素连接酶调控乳腺癌细胞增殖和侵袭能力
Diana David,Sankar Jagadeeshan,Ramkumar Hariharan et al.
Diana David et al.
Background: Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to respond to TGF- β/BMP signaling pathway. However, besides TGF-β/BMP pathway, ...
Elizabeth A Williamson,Yuehan Wu,Sudha Singh et al.
Elizabeth A Williamson et al.
Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that promotes both DNA double strand ...
Shang-Nuan Zhang,Dong-Sheng Pei,Jun-Nian Zheng
Shang-Nuan Zhang
CSN6 is one subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is an evolutionarily conserved multiprotein complex found in plants and animals and originally described as a repressor of light-dependent growth a...
Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting [0.03%]
视网膜母细胞瘤基因的新视野：第三次国际Rb会议报告
Seth M Rubin,Julien Sage
Seth M Rubin
The retinoblastoma tumor suppressor (Rb) pathway is mutated in most, if not all human tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family of transcription factors. In response to mitogenic signals, Cyc...
Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase [0.03%]
哺乳动物减数分裂前期黏着环复合体装载因子Nipbl定位于染色体轴结构
Katarzyna Kuleszewicz,Xiangwei Fu,Nobuaki R Kudo
Katarzyna Kuleszewicz
Background: Sister chromatid cohesion mediated by the cohesin complex is essential for accurate chromosome segregation during mitosis and meiosis. Loading of cohesin onto chromosomes is dependent on another protein comple...
A pool of peptides extracted from wheat bud chromatin inhibits tumor cell growth by causing defective DNA synthesis [0.03%]
从小麦芽染色质中提取的肽类通过导致缺陷DNA合成抑制肿瘤细胞生长
Loretta Mancinelli,Teresa Secca,Paula M De Angelis et al.
Loretta Mancinelli et al.
Background: We previously reported that a pool of low molecular weight peptides can be extracted by alkali treatment of DNA preparations obtained from prokaryotic and eukaryotic cells after intensive deproteinization. Thi...
Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis [0.03%]
通过促进凋亡使CDK4失活可提高乳腺癌细胞对放射线的敏感性
Katie R Hagen,Xiangbin Zeng,Mi-Young Lee et al.
Katie R Hagen et al.
Background: The discovery of molecular markers associated with various breast cancer subtypes has greatly improved the treatment and outcome of breast cancer patients. Unfortunately, breast cancer cells acquire resistance...
Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast [0.03%]
酵母有丝分裂后期完毕时Ama1p和Cdc20p的相互依赖退化终止APC/C泛素连接酶活性
Grace S Tan,Rebecca Lewandowski,Michael J Mallory et al.
Grace S Tan et al.
Background: The execution of meiotic nuclear divisions in S. cerevisiae is regulated by protein degradation mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase. The correct timing of APC/C activi...
Yuichiro Miyaoka,Atsushi Miyajima
Yuichiro Miyaoka
The liver has a remarkable capacity to regenerate. Even with surgical removal (partial hepatectomy) of 70% of liver mass, the remnant tissue grows to recover the original mass and functions. Liver regeneration after partial hepatectomy has ...