Fumihiko Okumura,Akiko Joo-Okumura,Kunio Nakatsukasa et al.
Fumihiko Okumura et al.
The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase activity mediated by the formation...
Sayantan Bose,Abir Kumar Panda,Shravanti Mukherjee et al.
Sayantan Bose et al.
Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies continue on its molecular mecha...
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex [0.03%]
对COP9信号体去泛素活性的增强是由同时发生的泛素化介导的：一种关于酶复合物调节机制的新见解
Gil Bornstein,Chagai Grossman
Gil Bornstein
Background: Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family proteins. Neddylation of Cul1 activates the ligase through some means of biochem...
Jorrit M Enserink
Jorrit M Enserink
The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cell homeostasis when the cell enc...
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos [0.03%]
癌症中的非整倍体和染色体不稳定：从大丰收到混沌
Maybelline Giam,Giulia Rancati
Maybelline Giam
Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of mutations conferring aggressive or drug-resistant phenotypes during cancer evolution. Chromosomal instability (CIN) is a form of GIN that involves f...
Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase [0.03%]
PCNA结合位点的CDKN1C突变通过阻碍进入S期来抑制细胞增殖
Kleiton S Borges,Valerie A Arboleda,Eric Vilain
Kleiton S Borges
CDKN1C (also known as P57 (kip2) ) is a cyclin-dependent kinase inhibitor that functions as a negative regulator of cell proliferation through G1 phase cell cycle arrest. Recently, our group described gain-of-function mutations in the PCNA-...
Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells [0.03%]
Cyclin E2是乳腺癌细胞中与NPAT相关的主要E周期素蛋白质
Samuel Rogers,Brian S Gloss,Christine S Lee et al.
Samuel Rogers et al.
Background: The cyclin E oncogene activates CDK2 to drive cells from G1 to S phase of the cell cycle to commence DNA replication. It coordinates essential cellular functions with the cell cycle including histone biogenesi...
Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells [0.03%]
组蛋白脱乙酰酶抑制剂处理后染色体稳定性的差异分布影响HCT116和WI-38细胞中的HP1蛋白质
Rodrigo González-Barrios,Ernesto Soto-Reyes,Ricardo Quiroz-Baez et al.
Rodrigo González-Barrios et al.
Background: Heterochromatin protein 1 (HP1) is important in the establishment, propagation, and maintenance of constitutive heterochromatin, especially at the pericentromeric region. HP1 might participate in recruiting an...
Lucian John Gagliardi,Daniel H Shain
Lucian John Gagliardi
Recent experiments revealing nanoscale electrostatic force generation at kinetochores for chromosome motions have prompted models for interactions between positively charged molecules in kinetochores and negative charge at and near the plus...
The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence [0.03%]
DNA复制检查点复合体Mrc1/Tof1/Csm3的亚基：动力学与相互依赖关系
Sonya Dimitrova Uzunova,Alexander Stefanov Zarkov,Anna Marianova Ivanova et al.
Sonya Dimitrova Uzunova et al.
Background: The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative M...