Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways [0.03%]
干扰素诱导的头颈部鳞状细胞癌凋亡通过线粒体和内质网应激相关途径与吲哚胺2，3-双加氧酶有关联
Siraj M El Jamal,Erin B Taylor,Zakaria Y Abd Elmageed et al.
Siraj M El Jamal et al.
Background: Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFNγ) is one of the common cytokines coordinating tumor immune response and ...
Rpl22 is required for IME1 mRNA translation and meiotic induction in S. cerevisiae [0.03%]
Rpl22是S. cerevisiae中IME1 mRNA翻译和有丝分裂诱导所需的
Stephen J Kim,Randy Strich
Stephen J Kim
Background: The transition from mitotic cell division to meiotic development in S. cerevisiae requires induction of a transient transcription program that is initiated by Ime1-dependent destruction of the repressor Ume6. ...
Insights into APC/C: from cellular function to diseases and therapeutics [0.03%]
APC/C的生物学功能及其在疾病治疗中的应用研究进展
Zhuan Zhou,Mingjing He,Anil A Shah et al.
Zhuan Zhou et al.
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, ...
Danrui Cui,Xiufang Xiong,Yongchao Zhao
Danrui Cui
Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological processes, including cell cycle progre...
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions [0.03%]
基于Cul2的E3泛素连接酶结构、调控及其生物学功能研究
Weijia Cai,Haifeng Yang
Weijia Cai
Background: Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and...
The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor [0.03%]
转录因子TBX3通过直接抑制p21(WAF1)Cdk 抑制剂的表达来促进细胞增殖
Tarryn Willmer,Shannagh Hare,Jade Peres et al.
Tarryn Willmer et al.
Background: TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been s...
Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications [0.03%]
Cul3-KLHL20泛素连接酶：生理功能、应激反应和疾病影响
Hsin-Yi Chen,Chin-Chih Liu,Ruey-Hwa Chen
Hsin-Yi Chen
Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic...
New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics [0.03%]
hippo信号通路在癌症发生和发展中的新型研究进展及展望
Mingjing He,Zhuan Zhou,Anil A Shah et al.
Mingjing He et al.
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of signaling proteins, facilitatin...
E J Lawrence,E Boucher,C A Mandato
E J Lawrence
Background: The role of the cytoskeleton in regulating mitochondrial distribution in dividing mammalian cells is poorly understood. We previously demonstrated that mitochondria are transported to the cleavage furrow durin...
C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response [0.03%]
C1D家族蛋白质在协调RNA加工、染色体浓缩和DNA损伤反应中的作用
Rebecca A Jackson,Jocelyn Shumei Wu,Ee Sin Chen
Rebecca A Jackson
Research on the involvement of C1D and its yeast homologues Rrp47 (S. cerevisiae) and Cti1 (S. pombe) in DNA damage repair and RNA processing has remained mutually exclusive, with most studies predominantly concentrating on Rrp47. This revi...