Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP 53-deficient cancer cells [0.03%]
原卟啉IX通过活化TAp73诱导TP53缺陷型肿瘤细胞发生凋亡
Alicja Sznarkowska,Anna Kostecka,Anna Kawiak et al.
Alicja Sznarkowska et al.
Background: The p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor sup...
Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis [0.03%]
Kif18a通过调节Sirt2介导的组蛋白H4去乙酰化来调控小鼠卵母细胞减数分裂中期纺锤体的构建和稳定
Feng Tang,Meng-Hao Pan,Xiang Wan et al.
Feng Tang et al.
Background: During oocyte meiosis, the cytoskeleton dynamics, especially spindle organization, are critical for chromosome congression and segregation. However, the roles of the kinesin superfamily in this process are sti...
Triple A patient cells suffering from mitotic defects fail to localize PGRMC1 to mitotic kinetochore fibers [0.03%]
具有有丝分裂缺陷的AAA患者细胞无法将PGRMC1定位到有丝分裂动粒微管纤维上
Ramona Jühlen,Dana Landgraf,Angela Huebner et al.
Ramona Jühlen et al.
Background: Membrane-associated progesterone receptors are restricted to the endoplasmic reticulum and are shown to regulate the activity of cytochrome P450 enzymes which are involved in steroidogenesis or drug detoxifica...
Estelle Willems,Matthias Dedobbeleer,Marina Digregorio et al.
Estelle Willems et al.
Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization. AurA favors th...
Cecil J Gomes,Michael W Harman,Sara M Centuori et al.
Cecil J Gomes et al.
Background: Live-cell fluorescence microscopy (LCFM) is a powerful tool used to investigate cellular dynamics in real time. However, the capacity to simultaneously measure DNA content in cells being tracked over time rema...
IMP/GTP balance modulates cytoophidium assembly and IMPDH activity [0.03%]
IMP/GTP平衡调节细胞奥菲迪乌姆组装和IMPDH活性
Gerson Dierley Keppeke,Chia Chun Chang,Min Peng et al.
Gerson Dierley Keppeke et al.
Background: Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregat...
Eg5 orchestrates porcine oocyte maturational progression by maintaining meiotic organelle arrangement [0.03%]
Eg5通过维持减数分裂细胞器排列来调控猪卵母细胞成熟进程
Yan Xie,Minghui Cheng,Shan Lu et al.
Yan Xie et al.
Background: Kinesin superfamily proteins are microtubule-based molecular motors essential for the intracellular transport of various cargos, including organelles, proteins, and RNAs. However, their exact roles during mamm...
Protein arginine methylation: an emerging regulator of the cell cycle [0.03%]
蛋白质精氨酸甲基化：一种新兴的细胞周期调节机制
Anita E Raposo,Sabine C Piller
Anita E Raposo
Protein arginine methylation is a common post-translational modification where a methyl group is added onto arginine residues of a protein to alter detection by its binding partners or regulate its activity. It is known to be involved in ma...
Hong-Zhen Wang,Si-Han Yang,Gui-Ying Li et al.
Hong-Zhen Wang et al.
The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits of condensin I and condensin II are involved in some human cancers. This...
Phasing in on the cell cycle [0.03%]
聚焦细胞周期
Steven Boeynaems,Peter Tompa,Ludo Van Den Bosch
Steven Boeynaems
Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate biochemical reactions. Moreove...