Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes [0.03%]
Kinesin-5 Eg5是小鼠精母细胞纺锤体组装和染色体整列所必需的
Zhen-Yu She,Ning Zhong,Kai-Wei Yu et al.
Zhen-Yu She et al.
Background: Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation an...
IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells [0.03%]
IGFBP5通过上皮间质转化和Akt信号通路增加细胞侵袭并抑制细胞增殖（胶质母细胞瘤细胞）
Chengyuan Dong,Junwen Zhang,Sheng Fang et al.
Chengyuan Dong et al.
Background: Recurrence of Glioblastoma multiforme (GBM) seems to be the rule despite combination therapies. Cell invasion and cell proliferation are major reasons for recurrence of GBM. And insulin-like growth factor bind...
A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration [0.03%]
EZH2和NOX4之间的正反馈调节年龄相关性椎间盘退变中髓核细胞衰老
Chang Liu,Libangxi Liu,Minghui Yang et al.
Chang Liu et al.
Background: The senescence of nucleus pulposus (NP) cells plays a vital role in the pathogenesis of intervertebral disc (IVD) degeneration (IDD). NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce...
Saba Rezaei-Lotfi,Ramin M Farahani
Saba Rezaei-Lotfi
Metazoan animals are characterized by restricted phenotypic heterogeneity (i.e. morphological disparity) of organisms within various species, a feature that contrasts sharply with intra-species morphological diversity observed in the plant ...
The essentiality landscape of cell cycle related genes in human pluripotent and cancer cells [0.03%]
人类多能细胞和癌细胞中与细胞周期相关基因的本质景观
Ruth Viner-Breuer,Atilgan Yilmaz,Nissim Benvenisty et al.
Ruth Viner-Breuer et al.
Background: Cell cycle regulation is a complex system consisting of growth-promoting and growth-restricting mechanisms, whose coordinated activity is vital for proper division and propagation. Alterations in this regulati...
Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome [0.03%]
泛素连接酶活化的调控机制
Shivangee Bansal,Swati Tiwari
Shivangee Bansal
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit, multifunctional ubiquitin ligase that controls the temporal degradation of numerous cell cycle regulatory proteins to direct the unidirectional cell cycle phases. Several ...
FGF-induced LHX9 regulates the progression and metastasis of osteosarcoma via FRS2/TGF-β/β-catenin pathway [0.03%]
FGF诱导的LHX9通过FRS2/TGF-β/β-catenin途径调节成骨肉瘤的发展和转移
Shuang-Qing Li,Chao Tu,Lu Wan et al.
Shuang-Qing Li et al.
Background: Fibroblast growth factor (FGF) and tumor growth factor-β (TGFβ) have emerged as pivotal regulators during the progression of osteosarcoma (OS). LHX9 is one crucial transcription factor controlled by FGF, how...
Choogon Lee
Choogon Lee
Cryptochromes (CRYs) are UVA and blue light photoreceptors present in all major evolutionary lineages ranging from cyanobacteria to plants and animals, including mammals. In plants, blue light activates CRYs to induce photomorphogenesis by ...
Tatiana G Ruksha
Tatiana G Ruksha
'Dormancy', in the context of carcinogenesis, is a biological phenomenon of decreased cancer cell proliferation and metabolism. In view of their ability to remain quiescent, cancer cells are able to avoid cell death induced by chemotherapeu...
Correction to: Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP 53-deficient cancer cells [0.03%]
纠正：原卟啉_ix通过代谢氨基叶酸诱导TP53缺陷癌细胞中肿瘤抑制因子TAp73的再激活和凋亡
Alicja Sznarkowska,Anna Kostecka,Anna Kawiak et al.
Alicja Sznarkowska et al.
[This corrects the article DOI: 10.1186/s13008-018-0043-3.].
Published Erratum
Cell division. 2019 Aug 29:14:10. DOI:10.1186/s13008-019-0052-x 2019