The budding yeast protein Chl1p is required for delaying progression through G1/S phase after DNA damage [0.03%]
DNA损伤后裂殖酵母蛋白质Chl1p延缓细胞由G1期进入S期所需英文摘要
Muhseena N Katheeja,Shankar Prasad Das,Suparna Laha
Muhseena N Katheeja
Background: The budding yeast protein Chl1p is a nuclear protein required for sister-chromatid cohesion, transcriptional silencing, rDNA recombination, ageing and plays an instrumental role in chromatin remodeling. This h...
Ral GTPase is essential for actin dynamics and Golgi apparatus distribution in mouse oocyte maturation [0.03%]
Ral GTP酶在小鼠卵母细胞成熟中的作用及其对肌动蛋白动力学和高尔基体分布的影响
Ming-Hong Sun,Lin-Lin Hu,Chao-Ying Zhao et al.
Ming-Hong Sun et al.
Background: Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane tran...
Julia Bonnet,Lise Rigal,Odile Mondesert et al.
Julia Bonnet et al.
Background: Cancer cell aggregation is a key process involved in the formation of tumor cell clusters. It has recently been shown that clusters of circulating tumor cells (CTCs) have an increased metastatic potential comp...
Microarray expression profile of mRNAs and long noncoding RNAs and the potential role of PFK-1 in infantile hemangioma [0.03%]
婴幼儿血管瘤的mRNA和长链非编码RNA表达谱及PFK-1的潜在作用
Kaiying Yang,Xuepeng Zhang,Linwen Chen et al.
Kaiying Yang et al.
Background: Infantile hemangioma (IH) is the most common benign tumor in children. Long noncoding RNAs (lncRNAs) play a critical role in tumorigenesis. However, the expression levels and biological functions of lncRNAs in...
Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells [0.03%]
体细胞重编程至多能干细胞过程中染色体发生异常变异
Xinyu Liu,Conghui Li,Kang Zheng et al.
Xinyu Liu et al.
Background: Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has opened new therapeutic possibilities. However, karyotypic abnormalities detected in iPSCs compromised their utility, especially chromos...
XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity [0.03%]
XMU-MP-1在人类微型器官模型中诱导生长停滞并拮抗细胞周期依赖性的紫杉醇毒性
Ellen Mitchell,Charlotte E L Mellor,Talveen S Purba
Ellen Mitchell
Background: XMU-MP-1 is an inhibitor of the Hippo pathway kinases MST1/2 and has been shown to promote the downstream activation of the pro-proliferative, pro-regenerative and anti-apoptotic transcriptional regulator YAP1...
Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe [0.03%]
咖啡因在探究假丝酵母中CDC25磷酸化、活性及泛素依赖性降解集成研究中的应用
John P Alao,Per Sunnerhagen
John P Alao
The evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2. Together with the Wee1 kinase, a negative regulator of Cdc2 activity, Cdc25 is thus a cen...
The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division [0.03%]
从磷酸酶的角度审视G2到M的转换：观察新的有丝分裂过程
Tom Lemonnier,Aude Dupré,Catherine Jessus
Tom Lemonnier
Cell division is orchestrated by the phosphorylation and dephosphorylation of thousands of proteins. These post-translational modifications underlie the molecular cascades converging to the activation of the universal mitotic kinase, Cdk1, ...
EZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin [0.03%]
EZH2抑制剂DZNep可增强顺铂存在时和不存在时肾小管上皮细胞的凋亡作用
Si-Qi Chen,Jia-Qi Li,Xiao-Qiao Wang et al.
Si-Qi Chen et al.
Background: The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repress...
Zhuojie Li,Chenxi Wu,Xiang Ding et al.
Zhuojie Li et al.
Background: Apoptosis plays pivotal roles in organ development and tissue homeostasis, with its major function to remove unhealthy cells that may compromise the fitness of the organism. Toll signaling, with the ancient ev...