Ethnic and racial-specific differences in levels of centrosome-associated mitotic kinases, proliferative and epithelial-to-mesenchymal markers in breast cancers [0.03%]
乳腺癌中与中心体相关的有丝分裂激酶，增殖和上皮间充质转化标志物的种族特异性差异研究
Yainyrette Rivera-Rivera,Geraldine Vargas,Neha Jaiswal et al.
Yainyrette Rivera-Rivera et al.
Molecular epidemiology evidence indicates racial and ethnic differences in the aggressiveness and survival of breast cancer. Hispanics/Latinas (H/Ls) and non-Hispanic Black women (NHB) are at higher risk of breast cancer (BC)-related death ...
The genomic stability regulator PTIP is required for proper chromosome segregation in mitosis [0.03%]
PTIP基因在有丝分裂染色体正确分离中的作用不可或缺
Fengxia Zhang,Mingxuan Wei,Haoran Chen et al.
Fengxia Zhang et al.
Background: The Pax transcription activation domain-interacting protein (PTIP) is a nuclear protein that is an essential component of H3K4 methylation for gene activation in vascular, kidney, B cell, and adipocyte develop...
dGLYAT modulates Gadd45-mediated JNK activation and cell invasion [0.03%]
dGLYAT通过调节Gadd45介导的JNK活化调控细胞侵袭作用
Meng Xu,Pu Ren,Juhui Tian et al.
Meng Xu et al.
Background: Cell invasion is a crucial step of tumor metastasis, finding new regulators of which offers potential drug targets for cancer therapy. Aberrant GLYAT expression is associated with human cancers, yet its role i...
Proteolysis dependent cell cycle regulation in Caulobacter crescentus [0.03%]
依赖蛋白酶体的细胞周期调控在 Caulobacter crescentus 中的作用机制研究
Nida I Fatima,Khalid Majid Fazili,Nowsheen Hamid Bhat
Nida I Fatima
Caulobacter crescentus, a Gram-negative alpha-proteobacterium, has surfaced as a powerful model system for unraveling molecular networks that control the bacterial cell cycle. A straightforward synchronization protocol and existence of many...
Trevor G Shepherd,Frederick A Dick
Trevor G Shepherd
In cancer, dormancy refers to a clinical state in which microscopic residual disease becomes non-proliferative and is largely refractory to chemotherapy. Dormancy was first described in breast cancer where disease can remain undetected for ...
Muyang Lin,Shuang Shuang Xie,Kuan Yoow Chan
Muyang Lin
The centrosome is a multifunctional organelle that is known primarily for its microtubule organising function. Centrosomal defects caused by changes in centrosomal structure or number have been associated with human diseases ranging from co...
Heat shock factor 1 suppression induces spindle abnormalities and sensitizes cells to antimitotic drugs [0.03%]
热休克因子1的抑制可诱发纺锤体异常并使细胞对抗有丝分裂药物产生敏感性
Hsiao-Hui Kuo,Zhi-Rou Su,Jing-Yuan Chuang et al.
Hsiao-Hui Kuo et al.
Background: Heat shock factor 1 (HSF1) is the master regulator of the heat shock response and supports malignant cell transformation. Recent work has shown that HSF1 can access the promoters of heat shock proteins (HSPs) ...
ROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs [0.03%]
ROMO1对猪前着床期胚胎发育过程中线粒体代谢的调控作用
Dongjie Zhou,Ming-Hong Sun,Song-Hee Lee et al.
Dongjie Zhou et al.
Background: Reactive oxygen species (ROS) modulator 1 (ROMO1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial ROS production and redox sensing. ROMO1 regulates ROS generation with...
MPS1 is involved in the HPV16-E7-mediated centrosomes amplification [0.03%]
MPS1参与HPV16-E7介导的中心体扩增过程
Yair Alfaro-Mora,Guadalupe Domínguez-Gómez,Rodrigo E Cáceres-Gutiérrez et al.
Yair Alfaro-Mora et al.
Background: It has been reported that the oncoprotein E7 from human papillomavirus type 16 (HPV16-E7) can induce the excessive synthesis of centrosomes through the increase in the expression of PLK4, which is a transcript...
Shaan N Chhabra,Brian W Booth
Shaan N Chhabra
Somatic stem cells are distinguished by their capacity to regenerate themselves and also to produce daughter cells that will differentiate. Self-renewal is achieved through the process of asymmetric cell division which helps to sustain tiss...