Development and validation of a two glycolysis-related LncRNAs prognostic signature for glioma and in vitro analyses [0.03%]
基于两个糖酵解相关长链非编码RNA的胶质瘤预后标志物的开发及验证及其体外分析研究
Xiaoping Xu,Shijun Zhou,Yuchuan Tao et al.
Xiaoping Xu et al.
Background: Mounting evidence suggests that there is a complex regulatory relationship between long non-coding RNAs (lncRNAs) and the glycolytic process during glioma development. This study aimed to investigate the progn...
SIRT4 is an independent prognostic factor in bladder cancer and inhibits bladder cancer growth by suppressing autophagy [0.03%]
SIRT4是膀胱癌独立预后因素并可通过抑制自噬抑制膀胱癌生长
Jie Yin,Guohao Cai,Huaiwen Wang et al.
Jie Yin et al.
Background: Nucleosome-localized sirtuin 4 (SIRT4) was found to function as an oncogene and tumor suppressor gene in different tumors. However, the clinical significance of SIRT4 in bladder urothelial carcinoma (BLCA) has...
Molecular mechanisms involved in regulating protein activity and biological function of MST3 [0.03%]
调控MST3蛋白活性及生物学功能的分子机制研究
Jing Qiu,Junzhi Xiong,Lu Jiang et al.
Jing Qiu et al.
Mammalian sterile 20-like (Ste20-like) protein kinase 3 (MST3) or serine/threonine-protein kinase 24 (STK24) is a serine/threonine protein kinase that belongs to the mammalian STE20-like protein kinase family. MST3 is a pleiotropic protein ...
circRNA_0001006 predicts prognosis and regulates cellular processes of triple-negative breast cancer via miR-424-5p [0.03%]
circRNA_0001006通过miR-424-5p预测三阴性乳腺癌预后和调控细胞过程
Jiaqi Liu,Linna Kong,Wenqing Bian et al.
Jiaqi Liu et al.
Background: circular RNAs (circRNAs) have been considered novel biomarker candidates for human cancers, such as triple-negative breast cancer (TNBC). circ_0001006 was identified as a differentially expressed circRNA in me...
Sustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancer [0.03%]
SHUGOSHIN同源物1持续下调可降低三阴性乳腺癌异种移植小鼠模型的肿瘤生长和转移能力
Shirley Jusino,Yainyrette Rivera-Rivera,Camille Chardón-Colón et al.
Shirley Jusino et al.
Background: Triple-negative breast cancer (TBNC) is an aggressive breast cancer subtype with a poor prognosis. Shugoshin-1 (SGO1) protects chromatids from early separation. Previous studies from our group have demonstrate...
Update of cellular responses to the efferocytosis of necroptosis and pyroptosis [0.03%]
细胞摄取坏死样(programmed)细胞死亡(necroptosis和pyroptosis)的更新反应
Chandra Agung Purnama,Anna Meiliana,Melisa Intan Barliana et al.
Chandra Agung Purnama et al.
Cell death is a basic physiological process that occurs in all living organisms. A few key players in these mechanisms, as well as various forms of cell death programming, have been identified. Apoptotic cell phagocytosis, also known as apo...
MiR-146b-5p/SEMA3G regulates epithelial-mesenchymal transition in clear cell renal cell carcinoma [0.03%]
MiR-146b-5p/SEMA3G调节透明细胞肾细胞癌的上皮间质转化
Mengxi Tang,Tao Xiong
Mengxi Tang
Objective: The primary purpose was to unveil how the miR-146b-5p/SEMA3G axis works in clear cell renal cell carcinoma (ccRCC). Methods: ...
Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis [0.03%]
非编码RNA调控网络在骨质疏松症Wnt信号通路中的作用机制研究
Fangyu An,Xiangrui Meng,Lingqing Yuan et al.
Fangyu An et al.
Non-coding RNA (ncRNA) is a type of non-protein-coding RNA molecule transcribed from the genome which performs broad regulation of a variety of biological functions in human cells. The Wnt signaling pathway is highly conserved in multicellu...
Robert F Brooks
Robert F Brooks
Attempts to map the Restriction Point in the mammalian cell cycle typically involve stimulating quiescent cells with mitogens for increasing intervals, removing the stimulus and then determining the proportion of cells that reach S phase at...
Circular RNA hsa_circ_0075323 promotes glioblastoma cells proliferation and invasion via regulation of autophagy [0.03%]
环状RNA hsa_circ_0075323通过调节自噬促进胶质母细胞瘤细胞的增殖和侵袭
Wenrui Zhang,Zhonggang Shi,Shouren Chen et al.
Wenrui Zhang et al.
Background: Protein p62 (sequestosome 1) encoded by gene SQSTM1 plays a vital role in mediating protectively selective autophagy in tumor cells under stressed conditions. CircSQSTM1 (hsa_circ_0075323) is a circular transc...