Preeclampsia-associated lncRNA FEZF1-AS1 regulates cell proliferation and apoptosis in placental trophoblast cells through the ELAVL1/NOC2L axis [0.03%]
子痫前期相关长链非编码RNA FEZF1-AS1通过ELAVL1/NOC2L轴调节胎盘滋养细胞的增殖和凋亡
Xudong Zhao,Fengyun Su,Qing Guo et al.
Xudong Zhao et al.
Background: LncRNAs have been shown to be involved in and control the biological processes of multiple diseases, including preeclampsia (PE). The impairment of trophoblast cell proliferation is recognized as a significant...
Slik maintains tissue homeostasis by preventing JNK-mediated apoptosis [0.03%]
Slik通过抑制JNK介导的细胞凋亡来维持组织稳态
Chenglin Li,Xiaojie Zhu,Xinyue Sun et al.
Chenglin Li et al.
Background: The c-Jun N-terminal kinase (JNK) pathway is an evolutionarily conserved regulator of cell death, which is essential for coordinating tissue homeostasis. In this study, we have characterized the Drosophila Ste...
Kynureninase knockdown inhibits cisplatin resistance in vivo and in vitro and impacts the prognosis of cervical adenocarcinoma [0.03%]
下调犬尿氨酸酶抑制顺铂耐药的体内和体外研究及其影响宫颈腺癌预后的价值
Jun-Wen Zhang,Ya-Nan Wang,Mei-Ling Zhong et al.
Jun-Wen Zhang et al.
Background: Chemotherapy resistance is a leading cause of treatment failure in cases of cervical adenocarcinoma (ADC), and no effective treatment approach has yet been found. We previously identified the differentially ex...
Rapid and accurate genotyping of human SNP rs671 in aldehyde dehydrogenase 2 gene using one-step CRISPR/Cas12b assay without DNA amplification [0.03%]
无需DNA扩增一步式CRISPR/Cas12b基因分型技术快速准确检测人ALDH2基因rs671多态性
Fang Wu,Yong Xue,Yan Wang et al.
Fang Wu et al.
Background: The SNP rs671 of Human aldehyde dehydrogenase (ALDH) is G-A transition at 1510th nucleotides, which is an important clinical indicator of alcoholic liver disease, digestive tract cancer and some drug efficienc...
The roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1 [0.03%]
METTL3通过mTOR而不是CDK1介导血管平滑肌细胞自噬和增殖的作用
Hanshen Luo,Xingliang Wu,Bo Huo et al.
Hanshen Luo et al.
Background: Aberrant proliferation of vascular smooth muscle cells (VSMCs) is the cause of neointima formation followed by vascular injury. Autophagy is involved in this pathological process, but its function is controver...
Expression of genes regulating cell division in porcine follicular granulosa cells [0.03%]
调控猪卵泡颗粒细胞增殖相关基因的表达
Jakub Kulus,Wiesława Kranc,Magdalena Kulus et al.
Jakub Kulus et al.
Background: Cell cycle regulation influences the proliferation of granulosa cells and affects many processes related to ovarian folliclular growth and ovulation. Abnormal regulation of the cell cycle can lead to many dise...
Role of microRNAs in regulation of doxorubicin and paclitaxel responses in lung tumor cells [0.03%]
微小核糖核酸在调节肺肿瘤细胞中多柔比星和紫杉醇反应中的作用
Amirhosein Maharati,Meysam Moghbeli
Amirhosein Maharati
Lung cancer as the leading cause of cancer related mortality is always one of the main global health challenges. Despite the recent progresses in therapeutic methods, the mortality rate is still significantly high among lung cancer patients...
Development and validation of a two glycolysis-related LncRNAs prognostic signature for glioma and in vitro analyses [0.03%]
基于两个糖酵解相关长链非编码RNA的胶质瘤预后标志物的开发及验证及其体外分析研究
Xiaoping Xu,Shijun Zhou,Yuchuan Tao et al.
Xiaoping Xu et al.
Background: Mounting evidence suggests that there is a complex regulatory relationship between long non-coding RNAs (lncRNAs) and the glycolytic process during glioma development. This study aimed to investigate the progn...
SIRT4 is an independent prognostic factor in bladder cancer and inhibits bladder cancer growth by suppressing autophagy [0.03%]
SIRT4是膀胱癌独立预后因素并可通过抑制自噬抑制膀胱癌生长
Jie Yin,Guohao Cai,Huaiwen Wang et al.
Jie Yin et al.
Background: Nucleosome-localized sirtuin 4 (SIRT4) was found to function as an oncogene and tumor suppressor gene in different tumors. However, the clinical significance of SIRT4 in bladder urothelial carcinoma (BLCA) has...
Molecular mechanisms involved in regulating protein activity and biological function of MST3 [0.03%]
调控MST3蛋白活性及生物学功能的分子机制研究
Jing Qiu,Junzhi Xiong,Lu Jiang et al.
Jing Qiu et al.
Mammalian sterile 20-like (Ste20-like) protein kinase 3 (MST3) or serine/threonine-protein kinase 24 (STK24) is a serine/threonine protein kinase that belongs to the mammalian STE20-like protein kinase family. MST3 is a pleiotropic protein ...