Antidiabetic Evaluation of New Pyrimidine-Thiazoline Hybrids Endorsed With Enzyme Kinetic Studies and Computational Analysis [0.03%]
基于酶动力学及计算研究的新型嘧啶-噻唑啉杂化抗糖尿病化合物评价
Gobind Kumar,Pule Seboletswe,Neha Manhas et al.
Gobind Kumar et al.
The prevalence of diabetes mellitus (DM) poses a serious global health concern, given its substantial contribution to mortality rates. Millions of people worldwide are affected by this disease, which is associated with severe complications....
Network Pharmacology and Experimental Validation to Identify Potential Key Compounds of Danhong Injection in the Treatment of Myocardial Infarction [0.03%]
基于网络药理学和实验验证的丹参注射液治疗心肌梗死潜在关键化合物筛选及作用机制研究
Chenrui Zhang,Yongqin He,Xuejiao Wei et al.
Chenrui Zhang et al.
Myocardial infarction (MI) is currently one of the leading causes of death worldwide, which can lead to loss of heart function and heart failure in severe cases. Danhong injection (DHI) contains two traditional Chinese medicines, Salvia mil...
Mitochondrial Dysfunction Induced by a Novel Salicylate-Based 1,2,3-Triazole Salt With Potent Antileishmanial Activity [0.03%]
一种具有强烈抗利什曼病活性的新型水杨酸盐类1,2,3-三氮唑盐引起线粒体功能紊乱
Bruno A De Oliveira,Ari Sérgio de Oliveira Lemos,João Pedro Reis Costa Bastos et al.
Bruno A De Oliveira et al.
Leishmaniasis is a neglected disease caused by Leishmania spp., with limited treatment options and no available vaccine. In this study, novel 1,2,3-triazole derivatives 4-substituted with salicylic esters and their salts were synthesized an...
Development of Quinoline-Isoxazole Hybrids With Selective Cytotoxicity and EGFR Kinase Binding: In Vitro and In Silico Approaches [0.03%]
基于体内外实验和计算机辅助设计的喹啉-异噁唑并合物抗肿瘤活性及EGFR激酶结合选择性研究
Yasemin Zeynep Şahin,Burcu Tan,Beyza Hamur et al.
Yasemin Zeynep Şahin et al.
Fourteen new quinoline-isoxazole hybrid compounds were synthesized through click reaction with different substituent groups on the isoxazole group. The in vitro therapeutic activeness of the synthesized hybrids had been assessed versus dive...
WGX-50 Promotes Healthy Ageing in Caenorhabditis elegans: A Combined Computational and Experimental Study [0.03%]
WGX-50促进秀丽隐杆线虫健康衰老：一种计算与实验结合的研究
Guihua Jia,Jiayi Li,Abbas Khan et al.
Guihua Jia et al.
WGX-50, a previously reported drug candidate for Alzheimer's disease, is derived from Zanthoxylum bungeanum Maxim commonly called Sichuan pepper. Its pharmacological actions for the long run benefit of human health have been extensively inv...
Sevoflurane Postconditioning Regulates Mitophagy Through the PINK1/Parkin Pathway to Alleviate Myocardial Microcirculatory Reperfusion Injury [0.03%]
异氟烷心肌缺血后处理通过PINK1/Parkin通路调控线粒体自噬减轻微循环再灌注损伤
Yanming Xue,Liqun Jia,Jianzhong Zhang et al.
Yanming Xue et al.
This study investigates whether sevoflurane postconditioning (SpostC) alleviates myocardial microcirculatory reperfusion injury by regulating mitophagy via the PTEN-induced kinase 1 (PINK1)/Parkin pathway. A mouse model of myocardial ischem...
Pachymic Acid Suppresses Endometrial Cancer Cell Migration by Inhibiting the NR3C1/TGF-β/Smad Signaling Pathway [0.03%]
朴公酸通过抑制NR3C1/TGF-β/Smad信号通路抑制子宫内膜癌细胞迁移
Yaqiong Wang,Li Ma
Yaqiong Wang
Pachymic acid exerts antitumor effects against renal cell carcinoma and breast, lung, and pancreatic cancers; however, its specific inhibitory effect on endometrial cancer progression remains unclear. Therefore, in this study, we investigat...
Discovery of Novel Oxadiazole-Triazole Hybrids as Lung and Cervical Cancer Agents: Synthesis, Docking, Biological Evaluation, and SAR Studies [0.03%]
作为肺癌和宫颈癌药物的新型氧噻唑-三氮唑杂化物的发现：合成、对接、生物评估及药效研究
Venkatraman Hegde,Raveendra Madhukar Bhat,Gangadhar V Muddapur et al.
Venkatraman Hegde et al.
The number of new cancer cases and cancer-related fatalities continues to rise nowadays as a result of better lives and higher survival rates. Recent research has primarily focused on developing multi-target drug designs. A new series of fl...
From Pharmacophore Models to Lead Compounds: Construction and Activity Evaluation of Novel Indoleamine 2,3-Dioxygenase-1 Inhibitors [0.03%]
从药效团模型到先导化合物：新型色氨酸2,3-二氧化酶抑制剂的构建及活性评价
Shiying Zhang,Anli Zhang,Bin Sun
Shiying Zhang
Indoleamine 2,3-dioxygenase-1 (IDO-1), as a crucial immunomodulatory target, plays a pivotal role in regulating immune function. In this study, the ligand-based pharmacophore model (HDAA) and the receptor-based pharmacophore model (HHDA) we...
New Anticancer 4-Aryldihydropyrimidinone-5-Carboxylates Targeting Hsp90 [0.03%]
新型抗癌4-芳基二氢嘧啶酮-5-羧酸酯类Hsp90靶向化合物
Cinzia Bordoni,Tia Z Elstow,Andrea Brancale et al.
Cinzia Bordoni et al.
Amplified expression of the heat shock protein 90 (Hsp90) chaperone within cancer cells is associated with poor patient prognosis, and is known to drive tumour invasion, treatment resistance and metastasis within a range of tumour types. Se...