Probing Cinnamamides and Benzamides as Anthelmintics: Discovery of Potent Drug-Like Agents Against Angiostrongylus cantonensis [0.03%]
一类新型抗菌活性的中药衍生物的研究及发现
Bruna L Lemes,Mariana A Siegl-Breno,Marina T Varela et al.
Bruna L Lemes et al.
Emergent helminthiases are increasingly impacting global health in both humans and animals, especially given the limited efficacy of existing drugs against these infections. Neuroangiostrongyliasis, an eosinophilic meningitis caused by Angi...
Perfluorooctane Sulfonate Exposure and Peripheral Artery Disease: Mendelian Randomization and Integrative Multi-Omics Systems Toxicology With Machine Learning [0.03%]
全氟辛烷磺酸暴露与外周动脉疾病：孟德尔随机化和整合多组学系统毒理学与机器学习研究
Xi Lan,Qiang Wu,Jun Zhou et al.
Xi Lan et al.
Epidemiological and experimental studies have linked legacy and emerging PFAS to adverse cardiovascular outcomes, yet most evidence remains observational and is susceptible to confounding, measurement error, and reverse causation. This stud...
In Silico Drug Repositioning Identifies SYK Kinase Inhibitors as Potential Neuroprotective Agents for Ataxia-Telangiectasia [0.03%]
基于计算的药物再定位研究发现SYK激酶抑制剂可能是共济失调-毛细血管扩张症的神经保护剂候选药物
Alessia Romano,Rocco Buccheri,Chiara Zagni et al.
Alessia Romano et al.
Ataxia-Telangiectasia (AT) is a rare neurodegenerative disorder characterized by progressive neuronal loss and chronic neuroinflammation. Emerging evidence indicates that aberrant overexpression of the adaptor protein TYROBP promotes sustai...
Synthesis of Peptide Analogs From Fish Venom With Potential Antimicrobial and Anticancer Activity [0.03%]
具有潜在抗菌和抗肿瘤活性的鱼类毒液肽类似物合成
Roberto de la Salud Bea,Qian Shen,Elaine Frawley et al.
Roberto de la Salud Bea et al.
Grammistin Pp2a is a 13 amino acid peptide found in the venom of the fish Pogonoperca punctata. In this work, the wild type and 13 analogs of this peptide have been synthesized. A myristic acid chain has been added to the N-terminus of 7 pe...
Design, Optimization and Mechanistic Insights Into Terpenoid-Derived Inhibitors of Protein Kinase C Iota [0.03%]
蛋白质激酶Cι的倍半萜类抑制剂的设计、优化及作用机制研究
Rachid Chahboun,Fernando Rodríguez-Serrano,Ángel Bueno et al.
Rachid Chahboun et al.
Protein kinase C iota (PKCι) is an atypical PKC isoform overexpressed in several human cancers and associated with tumor initiation, maintenance, and resistance to therapy. Meroxest, a synthetic naphthoquinone merosesquiterpene previously ...
Design, Synthesis, and In Vitro Biological Assessment of Novel Benzimidazole and Hydrazone Derivatives Against Pancreatic Cancer and Melanoma Cells [0.03%]
新型苯并咪唑和腙衍生物抗胰腺癌和黑色素瘤细胞的设计、合成及体外生物学评价
Beyza Ecem Oz Bedir,Tuba Ozdemir Sanci,Emine Terzi et al.
Beyza Ecem Oz Bedir et al.
In this study, novel Benzimidazole-Hydrazone derivatives (5A-5J) were synthesized and evaluated for their in vitro anticancer activities against Panc-1, SK-MEL-30, HeLa, and BEAS-2B cell lines. WST-1 cytotoxicity assays revealed that compou...
Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel Thiazolyl-Pyrazoline Derivatives as Potential EGFR Inhibitors [0.03%]
新型噻唑基吡唑啉衍生物作为EGFR抑制剂的设计、合成、生物评价及分子对接研究
Mayuri A Patil,Sachin S Bhusari,Pravin S Wakte
Mayuri A Patil
A novel series of thiazolyl-pyrazoline derivatives (MAP-1 to MAP-20) was designed and synthesized as potential epidermal growth factor receptor (EGFR) inhibitors. The structures of all compounds were confirmed by 1H NMR, 13C NMR, and HRMS a...
The Associations Between Dietary Flavonoid Intake and Neurodegenerative Diseases Risk: A Cross-Sectional Study [0.03%]
膳食类黄酮摄入与神经退行性疾病风险关系的横断面研究
Chenzhong Zong,Yang Dong,Xue Yu et al.
Chenzhong Zong et al.
The incidence of neurodegenerative diseases (NDs), primarily Alzheimer's disease and Parkinson's disease, has been steadily increasing, constituting a significant global public health challenge. This study aims to evaluate the associations ...
Skin eQTL-Cerebrospinal Fluid Metabolites-Keloid Axis: An Integrative Multi-Omics Mediation Mendelian Randomization Study [0.03%]
皮肤eQTL-脑脊液代谢物-瘢痕疙瘩轴：整合多组学中介孟德尔随机化研究
Jie Xu,Mengqi Bai,Tongyun Liu
Jie Xu
Keloids are fibroproliferative dermal disorders characterized by excessive extracellular matrix deposition and a strong tendency to recur, yet the mechanistic links between inherited genetic variation, molecular phenotypes and disease risk ...
Novel 2-Phenyl-1H-Pyrrole Derivatives as Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss [0.03%]
新型苯基吡咯衍生物作为线粒体丙酮酸载体抑制剂治疗脱发研究
Xingyu Wu,Han Zhang,Yilei Huang et al.
Xingyu Wu et al.
Hair follicle stem cells (HFSCs) play the primary role in the regulation of the hair growth cycle. Premature termination of the anagen phase accelerates the transition of hair follicles into the catagen and telogen phases, leading to hair l...