Improving Lung Injury in Sepsis-Related Systemic Inflammatory Response Syndrome Through Regulation of the TLR4/NF-κB Pathway and Macrophage Polarization by Ganoderic Acid A [0.03%]
灵芝酸A通过调控TLR4/NF-κB信号通路和巨噬细胞极化改善脓毒症全身炎症反应综合征肺损伤
Mingjie Zhu,Jianru Shang,Shan Che
Mingjie Zhu
This study aimed to investigate the effects and mechanisms of Ganoderic acid A (GAA) on lung injury associated with systemic inflammatory response syndrome (SIRS). Forty Sprague Dawley rats were divided into four groups: Control group, GAA ...
Plumbagin Triggers STING Pathway Activation to Suppress Non-Small Cell Lung Cancer Progression [0.03%]
Plumbagin通过激活STING信号通路抑制非小细胞肺癌进展
Li-Ping Kang,Ning-Ning Li,Pei-Sheng Chen et al.
Li-Ping Kang et al.
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Plumbagin (PLBG), a naturally occurring active naphthoquinone derived from Chinese herbal plants, exhibits anti-cancer effects across multiple cancer ...
Pioneering QSAR Modeling Study of FAP-Targeting Radiopharmaceuticals Used in Oncology [0.03%]
用于肿瘤学的FAP靶向放射性药物的开创性QSAR建模研究
Dorrin Fatehi,Zahra Hajimahdi,Mona Mosayebnia
Dorrin Fatehi
Fibroblast Activation Protein (FAP) is highly expressed in the tumor microenvironment, promoting cancer growth and spread. FAP inhibitors (FAPIs) labeled with radionuclides are increasingly used for cancer diagnosis and therapy. The present...
Design, Synthesis, Molecular Docking, ADME-T and In Vitro Anticancer Assessment of Phenyl-Substituted-Pyrimidin-Benzenesulfonamide Derivatives as Potential BRAFV600E /WT Inhibitors [0.03%]
设计、合成、分子对接、ADMET以及体外抗癌评估苯基取代的嘧啶-苯磺酰胺衍生物作为潜在的BRAFV600E/WT抑制剂
Ankit Kumar Singh,Vineet Prajapati,Vimlendu Kumar Sah et al.
Ankit Kumar Singh et al.
BRAF is one of the most commonly mutated oncogenes in human cancers. More than 90% of BRAF mutations are associated with malignant melanoma. Given the pivotal role of BRAFV600E/WT mutations in melanoma progression and therapy resistance, ou...
Antioxidant and Amylase, Glucosidase, and Tyrosinase Enzymes Inhibitory Potential of Genistein and 11-α-Hydroxyerysotrine Supported by In Silico and Network Pharmacology Approaches [0.03%]
基于计算机模拟和网络药理学的抗氧化及抗α-淀粉酶、葡萄糖苷酶和酪氨酸酶的研究：大豆异黄酮和11-α-羟基厄里索丁的联合应用研究
Nouran M Fahmy,Shaimaa Fayez,Gokhan Zengin et al.
Nouran M Fahmy et al.
The antioxidant and enzyme inhibition properties of the isoflavone genistein (1) and the alkaloid 11-α-hydroxyerysotrine (2) isolated from the leaves of Erythrina speciosa were assessed. Both compounds exhibited notable in vitro antioxidan...
Unveiling a New Cholinesterase Inhibitor Iridoid From Verbascum uschakense (Murb.) Hub.-Mor.: In Vitro and In Silico Evaluation [0.03%]
来源于Verbascum uschakense (Murb.) Hub-Mor.的新型乙酰胆碱酯酶抑制环烯醚萜的体内外及分子模拟研究
Rabia Sena Mındız,Gülaçtı Topçu,Didem Şöhretoğlu et al.
Rabia Sena Mındız et al.
Verbascum L., a member of the Scrophulariaceae family, is the second-largest genus in Turkish flora. It is represented by over 250 species, many of which have been used as folk medicine. This study aims to determine the cholinesterase inhib...
Procyanidin Alleviates Diabetic Retinopathy by Activating the Expression of Activating Transcription Factor 1 Expression to Upregulate Synoviolin 1 and Inhibit the High Mobility Group Box 1/Toll-Like Receptor 4 Pathway [0.03%]
黄烷醇通过激活转录因子1表达上调Synoviolin 1抑制高迁移率族蛋白1/ Toll样受体4信号通路治疗糖尿病视网膜病变
Limin Zheng,Yaodan Cao,Wuyun Lu et al.
Limin Zheng et al.
Diabetic retinopathy (DR) remains a major cause of vision loss among working-age individuals, significantly impairing quality of life in diabetic patients. While no definitive cure exists, Procyanidin (PRO), a polyphenolic compound, has sho...
Beyond ATP Synthase Inhibition: Chemical Diversification, Bioactivities, and Therapeutic Potential of Oligomycin A [0.03%]
超越ATP合成酶抑制作用：寡霉素A的化学多样性、生物活性及治疗潜力
Mohamed S Nafie,Muna A Alshams,Mohamed K Diab et al.
Mohamed S Nafie et al.
Oligomycin A, initially identified as a macrolide antibiotic and a mitochondrial ATP synthase inhibitor, has recently transitioned from a laboratory tool to a multifaceted agent with promising therapeutic and industrial applications. Its ir...
Kisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway [0.03%]
亲吻肽-10通过激活环磷酸腺苷/蛋白激酶A途径抑制胎盘滋养细胞胰岛素抵抗改善妊娠期糖尿病模型大鼠症状
Jianhua Li,Jinhuan Chen,Lin Lu et al.
Jianhua Li et al.
Gestational diabetes mellitus (GDM) is a common pregnancy complication that leads to insulin resistance (IR) and adversely affects both maternal and fetal health. Kisspeptin-10 (Kp-10), a peptide acting via G Protein-Coupled Receptor 54 (Gp...
A Covalent and Modulable Inhibitor of the Tubulin-Microtubule System: Insights Into the Mechanism of Cacalol [0.03%]
一种可调节的共价 tublin-微管系统抑制剂：Cacalol 作用机制研究
Edgar López-López,José L Medina-Franco,Eric Salinas-Arellano et al.
Edgar López-López et al.
Inhibitors of the tubulin-microtubule system are part of an effective strategy to treat different kinds of cancer, whose research has allowed scientists to discover and develop new and more selective molecules. Cacalol (1) is a natural prod...