Acacetin Attenuates Heatstroke-Induced Acute Liver Injury by Targeting the c-Jun/PTGS2 Pathway [0.03%]
Xiaolong Shu,Yizhan Wu,Yi Chen et al.
Xiaolong Shu et al.
Heatstroke-induced acute liver injury (HS-ALI) is primarily driven by hepatic oxidative stress and inflammation. Acacetin (5,7-dihydroxy-4'-methoxyflavone, AC) is a naturally occurring O-methylated flavone derived from Chrysanthemum × mori...
Cepharanthine Reverses Gefitinib Resistance in NSCLC by Concurrently Inhibiting AKT/P70S6K Survival Signaling and Activating STING-Mediated Immune Response [0.03%]
Li-Ping Kang,Hui-Hui Chen,Tong-Tong Lv et al.
Li-Ping Kang et al.
Acquired resistance to Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib, remains a major therapeutic challenge in EGFR-mutant non-small cell lung cancer (NSCLC). Here, we report that cepharanthine...
Integrative Multi-Omics and Molecular Simulations Identify PRKCD as a Biological Modulator in Colon Adenocarcinoma: Validation With Phoenix dactylifera Phytochemicals and Comparison With Rottlerin [0.03%]
Mohd Adnan,Arif Jamal Siddiqui,Mousa Alreshidi et al.
Mohd Adnan et al.
Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. Colon adenocarcinoma (COAD), the most common histological subtype, is characterized by a poor prognosis in advanced stages due to significant molecular heterog...
Comparative Study
Chemical biology & drug design. 2026 May;107(5):e70302. DOI:10.1111/cbdd.70302 2026
Preliminary Study on the Mechanism of Arctigenin in Alleviating Osteoarthritis Pain by Suppressing Chondrocyte Pyroptosis: The Potential Role of the POU2F1/GRB10 Axis [0.03%]
虎耳草素通过POU2F1/GRB10轴抑制软骨细胞焦亡缓解骨关节炎疼痛的机制初探
Tian-Jun Zhai,Wei Feng,Cheng-Cheng Zhu et al.
Tian-Jun Zhai et al.
Osteoarthritis (OA), the most prevalent form of arthritis globally, is characterized by debilitating pain driven by inflammatory and degenerative processes in chondrocytes. Here, we demonstrate that arctigenin (ATG), a bioactive lignan from...
Prunetin Protects Against Sepsis-Induced Acute Lung Injury by Inhibiting Inflammation and Oxidative Stress via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway [0.03%]
普鲁内丁通过调节TLR4/NF-κB/NLRP3炎性小体信号通路抑制炎症和氧化应激保护脓毒症诱导的急性肺损伤
Xuedong Zhang,Siqi Dai,Chaojie Li et al.
Xuedong Zhang et al.
Prunetin is a naturally occurring flavonoid with effective therapeutic potential against diverse diseases. This study aimed to investigate the potential properties of prunetin in alleviating lipopolysaccharide (LPS)-induced inflammatory res...
Emerging Design Principles at the Forefront of Mitochondrial Transplantation Using Engineering Methodologies: Current Achievements and Future Directions [0.03%]
工程学视角下线粒体移植新兴设计原理：现状与未来方向
Naoto Yoshinaga,Keiji Numata
Naoto Yoshinaga
Mitochondrial transplantation has gathered much attention as therapeutics to improve multiple mitochondrial functions simultaneously. While the administration of naked mitochondria into the target tissue has demonstrated therapeutic outcome...
Pyrazoline-Imidazopyridine Hybrids as Beclin-1 Mimetics Driving Dual Apoptotic and Autophagy in Breast Cancer [0.03%]
吡唑啉-咪唑并吡啶杂化物作为Beclin-1模因诱导乳腺癌细胞凋亡和自噬双重死亡
Rashmi Shivakumar,Narasimha M Beeraka,Riyaz Ali M Osmani et al.
Rashmi Shivakumar et al.
Breast cancer is a profound cause of mortality among women globally. Similar to BH3 mimetics, targeting the antiapoptotic Bcl-xL:Beclin1 protein complex is crucial to inducing apoptosis and autophagy, thereby suppressing tumor progression i...
Chemoresistance and Immune Suppression in Gastric Cancer Are Driven by PPDPF Overexpression [0.03%]
胃癌化疗耐药和免疫抑制由PPDPF过表达驱动
Chenqiang Pan,Rongxing Hu,Bing Wu et al.
Chenqiang Pan et al.
Gastric cancer (GC) remains a lethal malignancy, and there is a pressing need for novel therapeutic targets. This study aimed to identify key oncogenic drivers in GC. Through integrative bioinformatic analysis of TCGA and GEO transcriptomic...
Icaritin Inhibits Malignant Progression and Enhances Ferroptosis and Bortezomib Sensitivity by Suppressing HSP90AA1 Expression in Multiple Myeloma [0.03%]
伊卡替林通过抑制热休克蛋白90α表达抑制多发性骨髓瘤恶性进展并促其铁死亡和硼替佐米敏感性
Lin Shi,Dianliang Lv,Xueying Wang et al.
Lin Shi et al.
Multiple myeloma (MM) is a hematologic malignancy commonly treated with bortezomib (BTZ). However, treatment efficacy is often limited by the development of BTZ resistance. Icaritin has demonstrated broad anti-tumor activities. This study a...
Integrative Multi-Omics Analysis Identifies FTO as a Genetic and Epigenetic Link Between Metabolic Susceptibility and Staphylococcus aureus-Induced Airway Remodeling in Chronic Rhinosinusitis [0.03%]
整合多组学分析确定FTO为代谢易感性和金黄色葡萄球菌诱导的慢性鼻窦炎气道重塑之间的遗传和表观遗传联系基因
Xinjie Qiao,Dong Dong,Shuman Huang et al.
Xinjie Qiao et al.
This study identifies fat mass and obesity-associated protein (FTO) as a pivotal link between metabolic predisposition and pathogenesis associated with Staphylococcus aureus in chronic rhinosinusitis (CRS). These findings were established t...