Screening Potential Drugs From Nitric Oxide Donors for Treating Alopecia Based on Network Pharmacology and Experimental Validation [0.03%]
基于网络药理学和实验验证从供氮化合物中筛选脱发潜在治疗药物
Pan Guo,Mengke Sun,Hong Cui et al.
Pan Guo et al.
Nitric oxide (NO) was previously thought to have a beneficial role in hair growth, but it is unclear whether NO donors can encourage hair development. Therefore, this study aims to systematically investigate the physiological mechanisms und...
In Silico Exploration of Potential Inhibitors Targeting SARS-CoV-2 Non-Structural Protein 15 (Nsp15): A Comprehensive Overview of Current Research [0.03%]
针对SARS-CoV-2非结构蛋白15(Nsp15)的潜在抑制剂的分子对接研究——当前研究综述
Behnaz Yazdani,Hajar Sirous,Farnoosh Farzam et al.
Behnaz Yazdani et al.
The SARS-CoV-2 nonstructural protein 15 (Nsp15) is an endoribonuclease that plays a critical role in viral replication and immune evasion through its NendoU domain. The unique enzymatic mechanism of Nsp15 has attracted considerable attentio...
Correction to "2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling" [0.03%]
“2-羟基-3-甲氧蒽醌通过阻断 annexin a5 介导的磷脂酰肌醇-3-激酶/蛋白激酶b信号转导抑制肝细胞癌的发展”一文的更正
Published Erratum
Chemical biology & drug design. 2025 Dec;106(6):e70216. DOI:10.1111/cbdd.70216 2025
Brusatol Exerts Therapeutic Effects in Ulcerative Colitis by Regulating the UBE3A-LCN2-Mediated Ferroptosis and Inflammation Axis [0.03%]
溴沙坦通过调节UBE3A-LCN2介导的铁死亡和炎症轴在溃疡性结肠炎中发挥治疗作用
Xingzhuo Guan,Xiaohui Guan,Zhiping Yang et al.
Xingzhuo Guan et al.
Ulcerative colitis (UC), a chronic inflammatory bowel disorder with no clear etiology, causes diverse complications and severely impairs patients' quality of life. Lipocalin-2 (LCN2) is recognized as a potential fecal biomarker for UC. Brus...
Correction to "Synthesis, Cytotoxic Activity, and Molecular Docking Study of New Thiazole-Incorporated Indenopyridazine Derivatives as Potential Antiproliferative Drugs" [0.03%]
“新噻唑并吲哚吡啶衍生物作为潜在的抗增殖药物的合成、细胞毒性活性及分子对接研究”的更正通知
Published Erratum
Chemical biology & drug design. 2025 Dec;106(6):e70215. DOI:10.1111/cbdd.70215 2025
Therapeutic Potential of 6-Gingerol in Glioma: Mechanistic Insights and Experimental Validation [0.03%]
姜辣素治疗胶质瘤的潜力：机制见解和实验验证
Shan Miao,Wei Hua,Jin Wang et al.
Shan Miao et al.
Glioma, a prevalent malignancy globally, presents a serious threat to human health. Recent research has highlighted the significant anti-tumor properties of 6-gingerol (6-G), an active component of the traditional Chinese medicine ginger, t...
Platinum-Based Chemotherapeutics in the Modern Era: From Classical DNA-Targeting Mechanisms to Next-Generation Innovations in Cancer Therapy [0.03%]
现代铂类抗肿瘤药物：从经典的DNA作用机制到下一代抗癌创新疗法
Mohammad Bagher Shahsavani,Mahsa Heidari,Reza Yousefi et al.
Mohammad Bagher Shahsavani et al.
Thanks to their DNA-crosslinking methods, platinum-based chemotherapeutics-which were first introduced by the coincidental discovery of cisplatin in 1965-have long been a mainstay of cancer treatment, with notable effectiveness in treating ...
Design, Synthesis, Computational Modeling and Biological Evaluation of Novel N-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)cinnamamides as Potential Covalent Inhibitors for Oncology [0.03%]
设计、合成、计算建模及生物活性评价新型N-(7H-吡咯并[2,3-D]嘧啶-4-基)桂皮酰胺作为潜在的抗癌共价抑制剂
Rameshwar S Cheke,Prashant S Kharkar
Rameshwar S Cheke
A novel series of covalent pyrrolo[2,3-d]pyrimidine cinnamamides was synthesized and evaluated for anticancer activity. The compounds were tested against three cancer cell lines-MDA-MB-231 (triple-negative breast cancer), A549 (non-small ce...
Design and Synthesis of Holu-7, a Quinazolinone Derivative With an Active Stereo Geometry and Polar 2,4-Dihydroxyphenyl Group, as a Selective Anticancer Agent [0.03%]
一种具有活性立体结构和对位二羟基苯基的喹唑啉衍生物Holu-7的抗癌剂设计与合成
Kuo-Chu Lai,Hui-Hsia Hsieh,Yi-Liang Lu et al.
Kuo-Chu Lai et al.
Quinazolin-4-one scaffolds offer rich anticancer chemistry but often trade potency for selectivity. Building on a tubulin-targeting lead (MJ-65), 12 new derivatives (26-37) were synthesized to dissect geometry-activity relationships and enh...
In Silico and In Vitro Identification of New Eugenol Derivatives as Inhibitors of the Spike SARS-CoV-2 Protein Interaction With the ACE2 Host Receptor [0.03%]
计算和体外鉴定新的丁香酚衍生物作为抑制SARS-CoV-2刺突蛋白与宿主ACE2受体相互作用的抑制剂
Timoteo Delgado-Maldonado,Alonzo González-González,Adriana Moreno-Rodríguez et al.
Timoteo Delgado-Maldonado et al.
Coronavirus Disease-2019 (COVID-19) caused by SARS-CoV-2 remains a serious health concern worldwide. Inhibitors of the protein-protein interaction (iPPI) between the SARS-CoV-2 spike protein (S) and human Angiotensin-Converting Enzyme-2 (AC...