Application of Systems Genetics to Investigate Molecular Pathology of Early-Onset Colorectal Cancer [0.03%]
系统遗传学在早期结直肠癌分子病理研究中的应用
Minjae J Kim,Sydney L Carr,Vishnutheertha Kulkarni et al.
Minjae J Kim et al.
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths in the United States. The incidence of early-onset CRC (EOCRC) has been rising in the past few decades. Given the multifaceted nature of EOCRC, the genetic and...
Pan-Cancer Multi-Omics Analysis Reveals the Potential of ZDHHC16 in Tumor Progression and Immune Regulation [0.03%]
泛癌分析揭示ZDHHC16在肿瘤进展和免疫调节中的潜力
Haolong Zhang,Sen Wu,Yufei Ma et al.
Haolong Zhang et al.
S-palmitoylation is a crucial post-translational modification that regulates diverse cellular processes, particularly signalling pathways. The ZDHHC family of enzymes catalyzes this modification, however, the role of ZDHHC16 in cancer warra...
Pomegranate Peel Polyphenol Extract Ameliorates Hyperuricemia by Inhibiting Uric Acid Synthesis and Reabsorption [0.03%]
石榴皮多酚提取物通过抑制尿酸合成和重吸收改善高尿酸血症
Zeyu Yin,Shufei Liang,Gangao Yang et al.
Zeyu Yin et al.
Hyperuricemia (HUA) is a common metabolic disorder with limited safe and effective therapeutic options. This study integrated GEO dataset mining and network pharmacology to explore the anti-HUA efficacy and mechanism of pomegranate peel pol...
Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron [0.03%]
近年 conjugation chemistry 的进展扩大了DNA四面体的应用范围
Tyler J Rutherford,Christopher J Wilds
Tyler J Rutherford
The tetrahedral DNA nanostructure (TDN) has emerged as a premier, highly programmable framework for targeted drug delivery and diagnostics. This review provides a definitive, chemistry-first design guide for TDN engineering, systematically ...
Rational Design, Synthesis, and Biological Evaluation of New Substituted Dihydropyrimidinones as Antibacterial Agents and β-Lactamase Inhibitors [0.03%]
新型取代二氢嘧啶酮抗菌剂和β-内酰胺酶抑制剂的理性设计、合成及生物活性评价
Ahmed M Soliman,Heba Abdelrasheed Allam,Walaa R Mahmoud et al.
Ahmed M Soliman et al.
A series of new substituted 1,6-dihydropyrimidinones was designed, synthesized, and biologically evaluated as potential antibacterial candidates and β-lactamase enzyme inhibitors. All the synthesized compounds were tested for their antibac...
Multi-Omics Integration Reveals That SN-011 Targets JUNB to Upregulate ADGRE5 and Restore Vascular Endothelial Cell Communication in Ischemic Stroke [0.03%]
多组学整合分析揭示SN-011通过靶向JUNB上调ADGRE5恢复缺血性脑卒中血管内皮细胞间通讯
XiangLing Ou,ZunKe Gong
XiangLing Ou
Ischemic stroke (IS) is a cerebrovascular disease with high mortality and disability rates, currently lacking effective therapeutic targets. The STING inhibitor SN-011 shows potential in IS treatment, but its mechanism of action remains unc...
Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis [0.03%]
一种治疗内脏利什曼病的苯磺酸哌嗪衍生物的体内活性识别
Thibault Joseph William Jacques Dit Lapierre,Mariza Gabriela Faleiro de Moura Lodi Cruz,Guilherme Freitas de Lima Hercos et al.
Thibault Joseph William Jacques Dit Lapierre et al.
Benzenesulfonylpiperazines have been previously identified as a promising class against Chagas disease and leishmaniasis, two parasitic neglected tropical diseases. Thus, the pharmacokinetic profile of two potential leads against visceral l...
Curcumin-Loaded GelMA Microspheres Alleviate Osteoarthritis: Transcriptomic Evidence for Immune Microenvironment Remodeling and ECM Homeostasis Restoration [0.03%]
姜黄素负载的明胶甲基丙烯酸酯微球缓解骨关节炎：免疫微环境重塑和细胞外基质稳态恢复的转录组学证据
Bin Jiang,Xin Jiang,Shaobo Li et al.
Bin Jiang et al.
Osteoarthritis (OA) progression is driven by inflammatory mediators and immune dysregulation within the joint. Curcumin (Cur) possesses multi-target therapeutic potential. However, its clinical application is limited by poor solubility and ...
Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges [0.03%]
人工智能在药物发现中的应用及基础设施挑战：中药角度审视当前进展及未来展望
Amit Gangwal,Azim Ansari,Mohd Usman Mohd Siddique et al.
Amit Gangwal et al.
Medicinal plants represent a vast and evolutionarily refined reservoir of structurally diverse bioactive compounds that have historically contributed to major therapeutic breakthroughs. However, despite their pharmacological richness, syste...
Jiuwei Xiaozhi Decoction Alleviates High-Fat Diet-Induced MASLD by Suppressing Hepatic SREBP2-Driven Cholesterogenesis and Restoring PPARα-Mediated Fatty Acid Oxidation [0.03%]
九味小柴胡汤通过抑制肝脏SREBP2介导的胆固醇生物合成和恢复PPARα介导的脂肪酸氧化来缓解高脂饮食引起的非酒精性 steatohepatitis
Youcheng Ma,Xinrui Gao,Ji Wang et al.
Youcheng Ma et al.
Jiuwei Xiaozhi Decoction (JWXZ) is a nine-herb traditional Chinese medicine formula clinically used for hepatic steatosis and dyslipidemia, but its chemical basis and pharmacological mechanisms in metabolic dysfunction-associated steatotic ...