2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling [0.03%]
2-羟基-3-甲氧蒽醌通过阻断 annexin a5 介导的磷脂酰肌醇 3-激酶/蛋白激酶 b 信号抑制肝细胞癌的发展
Min Luo,Juanmei Mo,Chaoyuan Huang et al.
Min Luo et al.
Hepatocellular carcinoma (HCC), the most common subtype of primary liver cancer, remains a major cause of cancer-related mortality worldwide. Although 2-hydroxy-3-methylanthraquinone (HMA), a natural anthraquinone compound, has demonstrated...
New Thiadiazole-Benzenesulfonamide Hybrids as Dual B-Raf/VEGFR-2 Inhibitors With Promising Anti-Hepatic Cancer Activity [0.03%]
一类新型哒嗪并噻二唑苯磺酰胺B-RAF/VEGFR-2双靶点抑制剂及其抗肝癌活性研究
Aisha A Alsfouk,Hazem Elkady,Saber M Hassan et al.
Aisha A Alsfouk et al.
A new group of thiadiazole-benzenesulfonamide hybrids was designed, synthesized, and biologically evaluated as potential dual inhibitors targeting B-Raf and VEGFR-2 for cancer therapy. The cytotoxic activity of the synthesized derivatives w...
New Pyrazole-Based Tetrazole Derivatives: Synthesis, Characterization, and Their Vasorelaxant and α-Amylase Inhibition Activities [0.03%]
新型吡唑基四氮唑衍生物的合成、表征及血管松弛和α-淀粉酶抑制活性研究
Ahlam Oulous,Ikram Dib,Tarik Harit et al.
Ahlam Oulous et al.
A series of new linear pyrazole-based tetrazole derivatives 1-10 were synthesized and characterized. The structures of the intermediate compounds were confirmed using 1H and 13C NMR spectroscopy, as well as high-resolution mass spectrometry...
Multifaceted In Silico Screening Strategies Identifies Potent Inhibitors Facilitating Inhibition of ZNF726 Activity in Breast Cancer [0.03%]
多面的基于计算机的筛选策略识别出有效的抑制剂以抑制乳腺癌中的ZNF726活性
Shreetama Bandyopadhayaya,Pooja Yadav,Monika Kumari et al.
Shreetama Bandyopadhayaya et al.
Studies documented by our lab established ZNF726 to potently augment the tumorigenic behavior of breast cancer cells by increasing cellular cholesterol levels. Therefore, Zinc finger protein 726 (ZNF726) can be considered an attractive ther...
Structure-Based Bioisosterism Design, Synthesis, Antitumor and Toxicity Assessment of Novel Aplysinopsin Analogs [0.03%]
基于结构的生物等电子体设计、新型Aplysinopsin类似物的合成及其抗肿瘤和毒性评价
Bárbara Gonçalves Rivello,Julia Biz Willig,Jéssica Gotardi et al.
Bárbara Gonçalves Rivello et al.
Eight new LQFM's Aplysinopsin analogs (12a-h) were synthesized and were evaluated for their anticancer profile on MCF-7 (breast cancer), SiHA and HeLa (cervical cancer). The compounds were obtained through the rational drug design strategy,...
Computationally Guided Structural Modification of Centaureidin: A Novel Approach for Enhancing Antioxidant and Antitumor Activities for Drug Development [0.03%]
计算指导的 centsuroidin 结构修饰：增强抗氧化和抗肿瘤活性的新药物开发方法研究
Reem S Alruhaimi,Emadeldin M Kamel,Sulaiman M Alnasser et al.
Reem S Alruhaimi et al.
The development of novel therapeutic drugs with enhanced efficacy has gained significant attention in recent years. In this study, we aimed to enhance the radical scavenging and antitumor activities of centaureidin through computationally g...
In Vitro and In Silico Evaluation of Isatin-Derived Spirooxindoles as Antituberculosis Drug Candidates [0.03%]
体外和计算机辅助评估异靛衍生的螺氧吲哚类化合物作为抗结核病药物候选物的研究
Fernanda Rodrigues de Lima,Jéssika de Oliveira Viana,Aleff Cruz de Castro et al.
Fernanda Rodrigues de Lima et al.
Tuberculosis (TB) remains a major global health threat, exacerbated by multidrug-resistant Mycobacterium tuberculosis (MTB) strains. The development of new anti-TB agents is crucial. In this study, 17 isatin derivatives synthesized by our r...
Fast Determination of Protein Binding Constants and Sites to Active Flavonoids and Phenolic Acids by Affinity Capillary Electrophoresis and Fluorescence Spectroscopy [0.03%]
基于亲和毛细管电泳及荧光光谱法快速测定黄酮类及酚酸小分子与血浆蛋白结合常数及结合位点
Pingyi Zheng,Xinru Wang,Yuchen Cui et al.
Pingyi Zheng et al.
The interaction of small molecule drugs with human serum albumin (HSA) after entering the human blood circulation system profoundly affects their distribution and absorption in the body, and further influences the activity. Thus, the in-dep...