Design, Synthesis and Biological Evaluation of Aminoalkylated Paeonol Chalcone Derivatives [0.03%]
氨基取代芍药素查尔酮衍生物的设计、合成及生物活性评价
Jia-Chen Xu,Bei-Bei Feng,Hong Wu et al.
Jia-Chen Xu et al.
Twenty-six novel derivatives of paeonol chalcone were synthesized by introducing various hydrophilic aminoalkyl to the 2'-hydroxy of paeonol. Their antiproliferative activity was evaluated by MTT assay against five human cancer cell lines (...
Stigmasterol Inhibits Glioma Metastasis and Angiogenesis by Regulating Macrophage Polarization [0.03%]
天冬素通过调节巨噬细胞极化抑制胶质瘤转移和血管生成
Xiangying Li,Danni Huang,Danfeng Wang et al.
Xiangying Li et al.
Stigmasterol exhibits broad-spectrum anticancer effects, but whether it exerts anti-glioma effects through modulation of macrophage polarization remains unclear. Mouse bone marrow-derived macrophages (BMDMs) were isolated and induced to pol...
Estrone-α-2-Deoxy-Glucoside as a Targeted Therapy for Triple-Negative Breast Cancer: Aromatase Inhibition and Cytotoxicity [0.03%]
雌酮-α-2-脱氧葡萄糖苷作为三阴性乳腺癌的靶向疗法：芳香化酶抑制和细胞毒性作用
Tzu-Yu Huang,Meng-Ru Wang,Feng-Pai Chou et al.
Tzu-Yu Huang et al.
Aromatase inhibitors (AIs) are vital in the treatment of estrogen-dependent breast cancer, especially in postmenopausal women. In this study, a series of steroidal glycosides (SGs) derived from trans-androsterone (tAND), estrone (E1), and e...
Molecular Mechanisms and Efficacy of Tislelizumab, a PD-1 Inhibitor Developed in China, in Non-Small Cell Lung Cancer [0.03%]
特瑞普利单抗——中国自主研发的PD-1抑制剂在非小细胞肺癌中的疗效及分子机制分析
Yihao Liu,Wenjun Meng,Lu Pan et al.
Yihao Liu et al.
Lung cancer remains the leading cause of cancer incidence and mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of all lung cancer cases. Tislelizumab, a PD-1 inhibitor developed in China, has sho...
The Immuno-Metabolic Crosstalk in Lung Squamous Cell Carcinoma: Prognostic Insights and Therapeutic Clues [0.03%]
免疫代谢交叉对话在肺鳞状细胞癌中的预后洞察和治疗线索
Haoyuan Xue,Hongwei Li,Songyan Han et al.
Haoyuan Xue et al.
Lung squamous cell carcinoma (LUSC) has a poor prognosis due to the lack of effective targeted therapies, and its incidence has increased dramatically in recent years, creating an urgent need for new prognostic markers. Given that tumor imm...
Targeting the Autophagy-Apoptosis Axis in Osteosarcoma: Therapeutic Potential of Biocompounds: A Review [0.03%]
靶向骨肉瘤自噬-凋亡轴的生物化合物治疗潜力：综述
Oznur Bayraktar Ekmekcigil,Secil Eroglu,Shiv Bharadwaj et al.
Oznur Bayraktar Ekmekcigil et al.
Osteosarcoma is a prevalent form of cancer that develops in growing bones. The precise cause of this multifaceted disease remains uncertain. Yet, genetic, genomic and proteomic research has enhanced our understanding of the disruption in it...
Thiazole- and 1,3,4-Thiadiazole-Based Hybrids: Synthesis and In Vitro Cytotoxicity Against Human Cancer Cell Lines [0.03%]
噻唑和1,3,4-硫代三氮杂化合物的合成及其对人类癌细胞系的体外毒性研究
Emine Terzi,Tuba Ozdemir Sanci,Beyza Ecem Oz Bedir et al.
Emine Terzi et al.
Problems such as high toxicity, low selectivity, and drug resistance encountered in cancer treatment increase the need for more effective and safe anticancer agents. In this study, the anticancer effects of new compounds consisting of thiaz...
Prediction of Breast Cancer Lymph Node Metastasis by a Nomogram Model Integrating Pathomics, Radiomics, and Immunoscore [0.03%]
基于病理组学、影像组学和免疫评分的Nomogram模型预测乳腺癌淋巴结转移
Tian Xu,Jingyao Feng,Kun Zhang et al.
Tian Xu et al.
This study aimed to develop a noninvasive nomogram that integrates deep learning-pathomics, radiomics, and immunoscore to predict lymph node metastasis (LNM) in breast cancer. Pathological features from 1133 TCGA-BRCA slides were extracted ...
Daucosterol Targets PFKFB3 to Mitigates Sepsis-Induced Acute Lung Injury by Inhibiting Glycolysis and M1 Macrophage Polarization [0.03%]
水飞蓟素通过抑制糖酵解和M1型巨噬细胞极化缓解脓毒症诱导的急性肺损伤
Lulu Wang,Jingmin Zhou,Chuanfu Sun et al.
Lulu Wang et al.
Acute lung injury (ALI) is a severe inflammatory condition often triggered by infections. Glycolysis and macrophage polarization play critical roles in ALI pathogenesis. This study investigates the effects of Daucosterol on lipopolysacchari...
Tetramethylpyrazine Targets HDAC6-Mediated PINK1 Degradation to Alleviate Chronic Intermittent Hypoxia-Induced Injury in Human Bronchial Epithelial Cells (16HBE) [0.03%]
四甲基吡嗪通过靶向HDAC6介导的PINK1降解缓解慢性间歇性低氧诱导的人支气管上皮细胞(16HBE)损伤
Yanjie Chen,Hongye Chen,Zhixiong Huang et al.
Yanjie Chen et al.
Obstructive sleep apnea (OSA) is characterized by recurrent chronic intermittent hypoxia (CIH), which induces oxidative stress, inflammatory responses, and mitochondrial damage in bronchial epithelial cells. Tetramethylpyrazine (TMP) has be...