Curculigoside Induces Ferroptosis in Non-Small Cell Lung Cancer Cells Through a Mechanism Involving Wilms' Tumor 1-Associating Protein-Mediated m6A Modification of GTP Cyclohydrolase 1 [0.03%]
慈竹皂苷通过WTAP介导的GTP环水解酶I m6A修饰诱导非小细胞肺癌细胞铁死亡
Lizheng Lv,Pingyan Jin,Jiaqi Cheng et al.
Lizheng Lv et al.
Ferroptosis plays a critical role in non-small cell lung cancer (NSCLC) progression. Curculigoside (Cur) exhibits anti-cancer properties. This study aimed to elucidate the precise action of Cur on NSCLC ferroptosis. Various concentrations o...
Integrated Experimental and Computational Investigation of 7-Bromoochromone Thiosemicarbazones as α-Glucosidase Inhibitors [0.03%]
7-溴黄酮噻二唑碳二亚胺类α-葡萄糖苷酶抑制剂的集成实验和计算研究
Eshah Shahzadi,Uzma Ghaffar,Ajmal Khan et al.
Eshah Shahzadi et al.
Diabetes mellitus (DM) is a metabolic condition commonly marked by increased blood glucose levels and effectively managed with α-glucosidase inhibitors. In this study, a novel series of 7-bromochromone-based thiosemicarbazones 4(a-r) was s...
Novel Hexahydropyrimidine Derivatives as Potential Neutral Sphingomyelinase 2 Inhibitors: Synthesis, Metal Chelation, and In Silico Studies [0.03%]
新型六氢嘧啶衍生物作为潜在的中性鞘磷脂酶2抑制剂：合成，金属螯合和计算机模拟研究
Ozge Kuyrukcu Ozturk,Yasemin Dundar
Ozge Kuyrukcu Ozturk
Neutral sphingomyelinase 2 (nSMase2) plays a pivotal role in exosome biogenesis and the progression of several neurodegenerative disorders and cancers. In this study, a series of hexahydropyrimidine and tetrahydropyrimidine derivatives were...
Emerging Roles of Osmium Complexes in Cancer Therapy, Their Mechanism of Action, Challenges and Future Perspectives [0.03%]
用于癌症治疗的锇配合物的作用、作用机制、挑战和未来前景
Eman M Atiyah,Duha Majeed Hasan,Ahmad H Ibrahim et al.
Eman M Atiyah et al.
Since cisplatin was discovered and used as an anti-cancer agent in clinical settings, research into cancer treatments has revealed a number of possible drugs based on metal-containing scaffolds. This has produced a large number of metallodr...
Identification of Mitophagy-Related Genes With Diagnostic Value in Atherosclerosis Using Bioinformatics Analysis and Experiment Validation [0.03%]
基于生物信息学分析和实验验证的动脉粥样硬化线粒体自噬相关诊断标志基因筛选及功能研究
Zhe Chen,Zhongying Chen,Yuhao Wang et al.
Zhe Chen et al.
Atherosclerosis (AS) is a chronic inflammatory condition with complex molecular underpinnings, where mitophagy-selective mitochondrial autophagy-plays a critical yet poorly defined role. By integrating bulk and single-cell RNA sequencing da...
The Therapeutic Effect and Mechanism of Vismodegib on COPD: Focusing on NETs and Macrophage Polarization [0.03%]
伏立诺他在慢性阻塞性肺疾病中的治疗作用及机制：着重于NETs和巨噬细胞极化方面的研究
Ming Wu,Chao Quan,Li Yao et al.
Ming Wu et al.
The Hedgehog pathway may be involved in chronic obstructive pulmonary disease (COPD). Its inhibitor, Vismodegib, has therapeutic potential, but the underlying mechanisms require further investigation. A COPD mouse model was established usin...
New Antiproliferative Pyrazole/Quinoline Hybrids: Design, Synthesis, and Biological Evaluation as EGFR Inhibitors [0.03%]
新型抗增殖吡唑/喹啉杂环化合物的设计、合成及表小细胞肺癌EGFR抑制剂活性研究
Mai E Shoman,Heba A Hassan,Hesham A M Gomaa et al.
Mai E Shoman et al.
A series of new pyrazole/quinoline hybrids 11a-n was constructed and synthesized as prospective antiproliferative agents. The antiproliferative activities of the newly synthesized hybrids were assessed against a panel of four human cancer c...
From Synthesis to Efficacy: Synthesis, Structural Analysis, and Antiviral Activity of 5-(Trifluoromethoxy)-1H-indole-2,3-dione 3-Thiosemicarbazones [0.03%]
从合成到活性：5-(三氟甲氧基)-1H-吲哚-2,3-二酮3-硫半卡巴腙的合成、结构分析及抗病毒活性研究
Özge Soylu-Eter,Leentje Persoons,Lieve Naesens et al.
Özge Soylu-Eter et al.
Viral infections are a global cause of serious morbidity and mortality. The recent COVID-19 pandemic further testifies to the continued need to develop novel classes of antiviral agents with broad activity and high selectivity. In this work...
Pharmacophore-Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases [0.03%]
基于药效团的强力神经肽酶抑制剂的识别和分子特征鉴定：心血管疾病的生化及治疗意义
Chung-Ting Kuo,Yi-Chen Wu,Ji-Min Li et al.
Chung-Ting Kuo et al.
Neprilysin (NEP), a zinc-dependent metalloprotease involved in the degradation of bioactive peptides, represents a validated target for heart failure therapeutics. In this study, a pharmacophore-based virtual screening approach combined wit...
Design, Docking, ADMET, Pass, Synthesis and Bio-Evaluation of Novel 7-O-Substituted Chrysin-Based VEGFR-2 Inhibitors [0.03%]
新型7-O-取代黄酮素衍生物 vegfr-2 抑制剂的设计、对接、admet 成药性评价、合成及生物活性评价
Kalyani R Thombre,Krishna R Gupta,Milind J Umekar
Kalyani R Thombre
VEGFR-2 is a critical target in cancer therapy, facilitating tumor angiogenesis, yet existing inhibitors face toxicity and resistance issues. Chrysin, a flavonoid with anticancer properties, has VEGFR-2 characteristics but suffers from poor...