Xiuyi Ou,Sa Liu,Pengcheng Sun et al.
Xiuyi Ou et al.
Cardiovascular disease (CVD) remains the major burden on global health. However, the development and approval of novel CVD therapeutics have declined, largely due to their protracted timelines and prohibitive costs. Drug repurposing has eme...
Anti-Proliferative and Apoptotic Evaluation of a Novel Synthesized Acridine Hybrid With Anticipated Synergistic Effect to Paclitaxel on Breast Cancer Cells [0.03%]
新型合成吖啶杂化物抗增殖和促凋亡作用的评估及其与紫杉醇在乳腺癌细胞中产生协同效应的预期效果研究
Esraa A Aidy,Elshaymaa I Elmongy,Abdullah A S Ahmed et al.
Esraa A Aidy et al.
This work describes the design, synthesis, and anticancer evaluation of a new acridine hybrid (ACNP). ACNP showed cytotoxic effect with IC50 values of 4.3 and 10 μg/mL against MCF-7 and MDA-MB 231; respectively, versus CC50 value of 439.72...
Quercetin Suppresses Inflammation and Extracellular Matrix Degradation in Knee Osteoarthritis by Inhibiting E2F2 to Modulate SFRP5/Wnt5a Signaling [0.03%]
染料木素通过抑制E2F2来调节SFRP5/Wnt5a信号，从而在膝关节骨关节炎中抑制炎症和细胞外基质降解
Jinlong Yao,Juan Li,Yun Zhang et al.
Jinlong Yao et al.
Quercetin (QUR) has been shown to ameliorate knee osteoarthritis (KOA), but its precise mechanism remains unclear. This study aimed to determine whether QUR regulates KOA by modulating E2F Transcription Factor 2 (E2F2) and elucidate the und...
Epigallocatechin Gallate, Resveratrol, and Triptolide Are Candidate Natural Drugs Which Target Huh Proteins in Atherosclerosis Pathogenesis [0.03%]
表观遗传调节因子Huh在动脉粥样硬化发生中的功能及其小分子化合物干预研究
Xiaoshan Zhu,Yuanyuan Nie,Hongshen Zhang et al.
Xiaoshan Zhu et al.
The aim of this study was to screen and validate hub genes involved in atherosclerosis (AS) pathogenesis and explore potential natural drugs. The differentially expressed genes (DEGs) associated with AS were collected based on microarray da...
Coumarin-Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents [0.03%]
异香豆素增强的噻唑杂化物作为抗肿瘤和抗菌剂双重制剂
Islam K Matar,Magdi E A Zaki,Zeinab A Muhammad et al.
Islam K Matar et al.
Coumarins are a privileged scaffold in medicinal chemistry, renowned for diverse therapeutic activities including antiviral, anticancer, and neuroprotective effects. Building on our previous work with 3-substituted coumarins as inhibitors o...
Daniel K Afosah,Madhusoodanan Mottamal,Srabani Kar et al.
Daniel K Afosah et al.
Cathepsin G (CatG), a neutrophil serine protease, plays several roles in host defense, inflammation, and vascular pathology. Selective inhibition of CatG is therefore a compelling therapeutic strategy, yet existing inhibitors such as sulfat...
Fragment-Based Design of Pseudo-Natural Products, Synthesis, and Evaluation of Their HIV-1 Latency-Reversing Properties [0.03%]
基于片段的伪天然产物设计、合成及评估其逆转HIV-1潜伏特性
Solange A Tanyi,Donatus B Eni,Mohamed Abdelsalam et al.
Solange A Tanyi et al.
The goal of this project is to design, synthesize, and test compounds that combine fragments derived from natural products (NPs) for their HIV-1 latency-reversal properties, particularly those that act by histone deacetylase inhibition. A f...
Assessment of Antidiarrheal Activity of Fraxin in Chick: Synergistic Effects and Molecular Docking Study [0.03%]
在鸡模型中评估白蜡素抗腹泻作用的评价：协同效应及分子对接研究
Wahidul Alam,Salehin Sheikh,Raihan Chowdhury et al.
Wahidul Alam et al.
Fraxin (FRX), a natural compound, has gained attention for its potential therapeutic effects, particularly in gastrointestinal disorders. This study investigates the antidiarrheal activity of FRX in both in vivo and in silico models. In the...
Paeoniflorin Ameliorates Osteoarthritis via Ring Finger Protein 216/Optineurin-Mediated Autophagy Activation in Chondrocytes [0.03%]
环指蛋白216/优化蛋白介导的软骨细胞自噬激活在芍药苷改善骨关节炎中的作用
Cheng Peng,Ding Jiang,Ningyang Gao et al.
Cheng Peng et al.
Osteoarthritis (OA) is a prevalent degenerative joint disorder. Paeoniflorin (PF), a primary bioactive compound from Paeonia lactiflora roots, demonstrates therapeutic potential for OA. This study investigated the effects and mechanisms of ...