Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Induce ROS-Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2 [0.03%]
新型银(I)和金(I)N-杂环卡宾配合物通过ROS诱导的自噬在人类肝癌细胞系HepG2中诱导细胞凋亡
Rocchina Miglionico,Francesco Viceconte,Maria Francesca Armentano et al.
Rocchina Miglionico et al.
Hepatocellular carcinoma is one of the most aggressive malignancies worldwide, with limited treatment options and high resistance to conventional therapies. Developing novel therapeutic strategies that target alternative cell death mechanis...
High-Throughput Platform for Discovery of Chemical Inhibitors of Heat Shock Protein 70 (Hsp70): Adaptation for the Specialized Bacterial HscA-HscB-IscU Complex [0.03%]
高效筛选化学抑制剂的热休克蛋白70(Hsp70)平台：细菌特有的HscA-HscB-IscU复合物的适应性研究
Arielle Shkedi,Aneta Grabinska-Rogala,Jason Hernandez et al.
Arielle Shkedi et al.
Adenosine triphosphatases (ATPases) power essential cellular processes, but they commonly achieve full activity only within multi-protein assemblies, where cofactors and partner proteins tune their function. Yet, most high-throughput screen...
Thiadiazole-Derived VEGFR-2 Inhibitors: From Design to Anticancer Evaluation [0.03%]
噻二唑衍生物血管内皮生长因子受体抑制剂：从设计到抗肿瘤评价
Aisha A Alsfouk,Eslam B Elkaeed,Hazem Elkady et al.
Aisha A Alsfouk et al.
In this study, a series of novel thiadiazole derivatives (7a, 7b, 9a, 9b, and 9c) were rationally designed as potential VEGFR-2 inhibitors using a pharmacophore-guided strategy. The compounds were synthesized and assessed for their antiangi...
Tetrahydropalmatine Alleviates Osteoarthritis-Associated Pain and Inflammation by Suppressing KDM4A/MDM2/HIF-1α-Mediated M1 Macrophage Polarization [0.03%]
四氢帕马丁通过抑制KDM4A/MDM2/HIF-1α介导的M1型巨噬细胞极化来缓解骨关节炎相关疼痛和炎症
Xiaobo Chen,Xiaoyong Sun,Qiuming Zhong et al.
Xiaobo Chen et al.
Osteoarthritis (OA)-associated pain, driven by M1 macrophage polarization and inflammation, lacks effective therapies. Tetrahydropalmatine (THP), known for its anti-inflammatory and analgesic properties, was evaluated for its effects on OA-...
Design and Synthesis of New Triazol Derivatives as Aromatase Enzyme Inhibitors [0.03%]
新型三唑衍生物作为芳香化酶抑制剂的设计与合成
Abdullah Çelik,Hayrani Eren Bostancı,Şennur Görgülü et al.
Abdullah Çelik et al.
In this study, novel triazole derivatives were designed and synthesized for potential breast cancer treatment. A series of 1,2,4-triazole compounds bearing a 2,4-difluorophenyl moiety (3a-3r) was obtained through a two-step organic synthesi...
Integrative Experimental Paradigm of Oxadiazole-Schiff Base Hybrids: Pharmacophore-Driven Docking Simulations and DFT Insights Toward Antidiabetic Therapeutic Discovery [0.03%]
基于药效团的分子对接模拟和DFT洞察：氧化氮杂环-Schiff碱化合物抗糖尿病治疗发现的一体化实验范式
Aisha Bibi,Mostafa E Salem,Shoaib Khan et al.
Aisha Bibi et al.
Diabetes mellitus and gastrointestinal infections remain major global health concerns, contributing to high morbidity, mortality, and economic burden. To address these challenges, a series of oxadiazole-bearing imine scaffolds were designed...
Berberine Ameliorates Pulmonary Fibrosis via Downregulating the TGFBR2-Mediated Signaling [0.03%]
巴马汀通过下调TGFBR2介导的信号通路改善肺纤维化
Yichao Zhao,Qi Li,Huihui Zhu et al.
Yichao Zhao et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial lung disease without any effective treatment. Berberine (BBR), a botanical alkaloid, possesses extensive biological activities and has significant therapeu...
Rutaecarpine Attenuates Ovalbumin-Induced Asthma in Mice by Regulating the NF-κB Pathway [0.03%]
rutaecarpine通过调节NF-κB通路减弱卵清蛋白诱导的小鼠哮喘
Kongbo Chen,Junwei Chen
Kongbo Chen
Pediatric asthma is a common chronic condition with several pathological features, including airway inflammation, remodeling, and oxidative stress. Rutaecarpine (RUT), a bioactive alkaloid, exhibits therapeutic efficacy against various alle...
Design, Synthesis, and Evaluation of Bis-Chalcones and Bis-Flavones as Selective COX-2 Inhibitors [0.03%]
茋的衍生物作为选择性环氧合酶-2抑制剂的设计、合成及评价
Rui Pereira,Marisa Freitas,Alberto N Araújo et al.
Rui Pereira et al.
Over the past two decades, the search for safe and effective COX-2 inhibitors has spurred extensive research on flavonoids. Within this context, synthetic flavonoid dimers have emerged as a promising subclass with potential anti-inflammator...
Identification of 5-Gene Prognostic Markers and Functional Verification of RRBP1 in 5-Fluorouracil Resistance of Colorectal Cancer by Multi-Omics Analysis and Experimental Verification [0.03%]
基于多组学分析和实验验证的结直肠癌氟尿嘧啶耐药型五基因标志物鉴定及RRBP1功能确证
Hui Ge,Zheng Xiao,Peiming Zheng et al.
Hui Ge et al.
Acquired resistance to 5-fluorouracil (5-FU) is a primary clinical challenge in colorectal cancer (CRC) treatment. Our study aimed to identify key factors predictive of 5-FU resistance and to elucidate their functional mechanisms by combini...