Cycloastragenol Ameliorates Psoriasis by Promoting Keratinocyte Autophagy via Modulating Subcellular Localization of ZKSCAN3 [0.03%]
环马兜铃酸基因醇通过调控ZKSCAN3亚细胞定位促进角质形成细胞自噬从而改善银屑病
Jie Xia,Du Zhang,Teng Zhang et al.
Jie Xia et al.
Psoriasis is a prevalent chronic skin disease. Cycloastragenol (CAG) has been shown to activate autophagy and alleviate epidermal keratinocyte hyperproliferation in psoriasis. This study aimed to clarify the mechanism of CAG-mediated autoph...
CD163 and TYROBP Are Two Therapeutic Targets for Hyperglycemia-Induced Mesangial Cell Stress [0.03%]
CD163和TYROBP是高血糖诱导的系膜细胞应激的两个治疗靶点
Zhang Ran,Zhang Guiling,Fan Yanna et al.
Zhang Ran et al.
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes. This study aimed to identify hub genes and explore potential therapeutic drugs for DN. Differentially expressed genes were analyzed between DN and normal samples ...
Multimodal Fusion of mpMRI Radiomics, Clinical Features, and Hematological Biomarkers Enhances Machine Learning-Based Prediction of Biochemical Recurrence in Prostate Cancer Patients [0.03%]
基于多模式融合的机器学习前列腺癌生化复发预测模型研究
Yinxing Zhu,Zeyu Yang,Zhipeng Liu et al.
Yinxing Zhu et al.
To develop and validate an interpretable machine-learning model for early prediction of biochemical recurrence (BCR) by fusing multiparametric MRI radiomics, clinical variables, and hematological biomarkers. A total of 172 patients (115 BCR...
Network Pharmacology and Transcriptomic Analysis Reveal the Mechanism by Which Ginsenoside CK Remodels the Tumor Immune Microenvironment to Inhibit Liver Cancer Progression [0.03%]
网络药理学和转录组分析揭示红参皂苷CK重塑肿瘤免疫微环境抑制肝癌进展的机制
Fangzhi Ye,Yong Wang,Qiaohui Du et al.
Fangzhi Ye et al.
The study aimed to investigate the mechanism by which ginsenoside CK downregulates EZH2 to activate the dendritic cell-NK cell axis, promoting antitumor immunity in hepatocellular carcinoma (HCC). Potential targets of ginsenoside CK for HCC...
Multi-Omics and Molecular Dynamics Analysis for Biomarker Discovery in Chronic Rhinosinusitis With Nasal Polyps [0.03%]
慢性鼻窦炎伴鼻息肉的多组学及分子动力学生物标志物筛选研究
Qian Guo,Xinjie Qiao,Shuman Huang et al.
Qian Guo et al.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifaceted inflammatory condition that significantly affects patients clinically. It is vital to comprehend the basic molecular mechanisms and to discover new biomarkers. This researc...
Identification of New CD36 Antagonists by Structure-Based Virtual Screening [0.03%]
基于结构的虚拟筛选识别新的CD36拮抗剂
Sandra L Guerrero-Rodríguez,Luis Córdova-Bahena,Fabiola Cortés-Mendoza et al.
Sandra L Guerrero-Rodríguez et al.
CD36 is a transmembrane glycoprotein that facilitates the uptake of fatty acids and oxidized low-density lipoproteins. CD36 is overexpressed in various types of cancer and CD36+ cancer cells display enhanced malignancy, including resistance...
Synthesis of New Hydrazone Derivatives, Characterization, Single Crystal X-Ray, Antimicrobial, SEM, and DFT Studies [0.03%]
新型腙衍生物的合成、表征、单晶X射线分析、抗菌活性、扫描电镜及密度泛函理论研究
Hakan Ünver,Abdüllatif Karakaya,Ülküye Dudu Gül et al.
Hakan Ünver et al.
Fifteen new hydrazine derivatives were synthesized and structurally characterized using NMR (1H NMR and 13C NMR) spectroscopy techniques. Furthermore, the crystal structure of compound 1647 was figured out by the single crystal X-ray analys...
Synthesis, Cytotoxic Activity, and Molecular Docking Study of New Thiazole-Incorporated Indenopyridazine Derivatives as Potential Antiproliferative Drugs [0.03%]
一类新型噻唑并茚吡啶杂衍生物的合成、抗肿瘤活性及分子对接研究
Alaa M Alqahtani,Sultan I Alkbaysi,Mariam Mojally et al.
Alaa M Alqahtani et al.
Cancer is among the leading causes of death in the world today. Several strategies were used to control cancer including chemotherapy, radiotherapy and targeted therapy. Among the problems related to antiproliferative chemotherapy against c...
Transformer-Based Model for Drug Design and Therapy Response Prediction [0.03%]
基于变压器模型的药物设计及治疗反应预测方法
Zheng Gu,Junxian Yu
Zheng Gu
The use of transformer models in drug design is gradually emerging. The models are applied in chemical structure prediction and target discovery. Textual sequences and graphs are commonly used to describe molecules. In this review, we discu...
Design of Hybrid Bioactive Peptides Derived From Cecropin and Cathepsin for Therapeutic Application [0.03%]
基于蚕蛹素和半胱氨酸蛋白酶的杂化生物活性肽的设计及其应用研究
Gabriele Santos Cepinho,Bruna Vitória Scavassa,Gabrielle L de Cena et al.
Gabriele Santos Cepinho et al.
The escalating global health crisis of antimicrobial resistance demands the urgent development of novel therapeutic agents with new mechanisms of action. Bioactive peptides (BAPs), and specifically antimicrobial peptides (AMPs), represent a...