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Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (alpha-aminoacyl)benzotriazoles [0.03%] 利用N-Fmoc保护的(α-氨酰)苯并三唑进行微波辅助固相多肽合成
Alan R Katritzky,Niveen M Khashab,Megumi Yoshioka et al. Alan R Katritzky et al.
A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(alpha-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.
Anticancer activity of selected phenolic compounds: QSAR studies using ridge regression and neural networks [0.03%] 选择酚类化合物的抗肿瘤活性：用岭回归和神经网络进行QSAR研究
Sisir Nandi,Marjan Vracko,Manish C Bagchi Sisir Nandi
Phenol and its congeners are known to induce caspase-mediated apoptosis activity and cytotoxicity on various cancer cell lines. Apoptosis, scavenging of radicals, antioxidant, and pro-oxidant characteristics are primarily responsible for th...
Multi-way analysis of quantum topological molecular similarity descriptors for modeling acidity constant of some phenolic compounds [0.03%] 基于量子拓扑分子相似性描述符的多维分析在某些酚类化合物酸常数建模中的应用
Mahnaz Esteki,Bahram Hemmateenejad,Taghi Khayamian et al. Mahnaz Esteki et al.
Three-way analyses of quantum topological molecular similarity descriptors were used for quantitative structure property relationship modeling of the acidity constant of some phenol derivatives. A three-way data was built for different mole...
Osman A B S M Gani Osman A B S M Gani
Docking and scoring tools are often used in the early stages of drug discovery projects today. Because the language of this field of drug design often includes intermingled terms of physics, chemistry, biology, and medicine, the significant...
Efficient use of the iron ortho-nitrophenylporphyrin chloride to mimic biological oxidations of dimethylaminoantipyrine [0.03%] 有效利用铁邻硝基苯基卟啉氯化物模拟二甲氨基安替比林的生物氧化反应
Marc J Bazin,Helen Shi,Jeannine Delaney et al. Marc J Bazin et al.
Major metabolites of dimethylaminoantipyrine have been synthesized using iron ortho-nitrophenylporphyrin chloride as biomimetic catalyst. Reactivity of iron tetrakis-ortho-nitrophenylporphyrin chloride [Fe(TNO2PP)Cl] has been compared with ...
Dihydropyridine derivatives to overcome atypical multidrug resistance: design, synthesis, QSAR studies, and evaluation of their cytotoxic and pharmacological activities [0.03%] 克服非典型多药耐药的二氢吡啶衍生物的设计、合成、QSAR研究及其细胞毒性和药理活性评价
Ahmad R Mehdipour,Katayoun Javidnia,Bahram Hemmateenejad et al. Ahmad R Mehdipour et al.
Multidrug resistance (MDR) is defined as resistance of tumor cells to the cytotoxic action of multiple structurally dissimilar and functionally divergent drugs commonly used in chemotherapy. Until now, there is no evidence for the effect of...
Synthesis, QSAR and calcium channel modulator activity of new hexahydroquinoline derivatives containing nitroimidazole [0.03%] 含硝基咪唑的新六氢喹啉衍生物的合成、QSAR及钙通道调节活性研究
Ramin Miri,Katayoun Javidnia,Hossein Mirkhani et al. Ramin Miri et al.
The discovery that 1,4-dihydropyridine class of calcium channel antagonists inhibit Ca2+ influx represented a major therapeutic advance in the treatment of cardiovascular disease. In contrast to the effects of known calcium channel blockers...
A template-assembled model of the N-peptide helix bundle from HIV-1 Gp-41 with high affinity for C-peptide [0.03%] 一个模板组装的HIV-1GP41N肽螺旋束模型与C肽结合亲和力高
Weiming Xu,John W Taylor Weiming Xu
The infection of target cells by HIV-1 is initiated by fusion of the viral and cell membranes, which is mediated by the viral glycoproteins, gp120 and gp41. After initial cell binding by gp120, the folding of gp41 to form a stable six-helix...
Anti-proliferative and pro-apoptotic properties of 3-bromoacetoxy calcidiol in high-risk neuroblastoma [0.03%] 3-溴乙酰氧基麦角钙化醇对高危神经母细胞瘤的抗增殖和促凋亡作用
Thilo S Lange,Rakesh K Singh,Kyu Kwang Kim et al. Thilo S Lange et al.
The cytotoxic, anti-proliferative and apoptotic effects of 3-Bromoacetoxy Calcidiol (B3CD), a derivative of vitamin D3 precursor calcidiol, on human neuroblastoma (NB) cells were examined. NB, predominantly a tumor of early childhood, is th...
Insight into the metabolism rate of quinone analogues from molecular dynamics simulation and 3D-QSMR methods [0.03%] 基于分子动力学模拟和三维QSMR的生物须酸类似物代谢速率研究新见解
Hai-Feng Chen,Mao-Ying Wu,Zhuo Wang et al. Hai-Feng Chen et al.
Molecular dynamics simulation was applied to investigate the metabolism mechanism for quinone analogues. Favourable hydrogen bonds between ligand and NQO1, and parallel orientation between ligand and flavin adenine dinucleotide could explai...