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期刊名:Chemical biology & drug design

缩写:CHEM BIOL DRUG DES

ISSN:1747-0277

e-ISSN:

IF/分区:3.2/Q3

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共收录本刊相关文章索引193
Alan R Katritzky,Niveen M Khashab,Megumi Yoshioka et al. Alan R Katritzky et al.
A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(alpha-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.
Sisir Nandi,Marjan Vracko,Manish C Bagchi Sisir Nandi
Phenol and its congeners are known to induce caspase-mediated apoptosis activity and cytotoxicity on various cancer cell lines. Apoptosis, scavenging of radicals, antioxidant, and pro-oxidant characteristics are primarily responsible for th...
Mahnaz Esteki,Bahram Hemmateenejad,Taghi Khayamian et al. Mahnaz Esteki et al.
Three-way analyses of quantum topological molecular similarity descriptors were used for quantitative structure property relationship modeling of the acidity constant of some phenol derivatives. A three-way data was built for different mole...
Osman A B S M Gani Osman A B S M Gani
Docking and scoring tools are often used in the early stages of drug discovery projects today. Because the language of this field of drug design often includes intermingled terms of physics, chemistry, biology, and medicine, the significant...
Marc J Bazin,Helen Shi,Jeannine Delaney et al. Marc J Bazin et al.
Major metabolites of dimethylaminoantipyrine have been synthesized using iron ortho-nitrophenylporphyrin chloride as biomimetic catalyst. Reactivity of iron tetrakis-ortho-nitrophenylporphyrin chloride [Fe(TNO2PP)Cl] has been compared with ...
Ahmad R Mehdipour,Katayoun Javidnia,Bahram Hemmateenejad et al. Ahmad R Mehdipour et al.
Multidrug resistance (MDR) is defined as resistance of tumor cells to the cytotoxic action of multiple structurally dissimilar and functionally divergent drugs commonly used in chemotherapy. Until now, there is no evidence for the effect of...
Ramin Miri,Katayoun Javidnia,Hossein Mirkhani et al. Ramin Miri et al.
The discovery that 1,4-dihydropyridine class of calcium channel antagonists inhibit Ca2+ influx represented a major therapeutic advance in the treatment of cardiovascular disease. In contrast to the effects of known calcium channel blockers...
Weiming Xu,John W Taylor Weiming Xu
The infection of target cells by HIV-1 is initiated by fusion of the viral and cell membranes, which is mediated by the viral glycoproteins, gp120 and gp41. After initial cell binding by gp120, the folding of gp41 to form a stable six-helix...
Thilo S Lange,Rakesh K Singh,Kyu Kwang Kim et al. Thilo S Lange et al.
The cytotoxic, anti-proliferative and apoptotic effects of 3-Bromoacetoxy Calcidiol (B3CD), a derivative of vitamin D3 precursor calcidiol, on human neuroblastoma (NB) cells were examined. NB, predominantly a tumor of early childhood, is th...
Hai-Feng Chen,Mao-Ying Wu,Zhuo Wang et al. Hai-Feng Chen et al.
Molecular dynamics simulation was applied to investigate the metabolism mechanism for quinone analogues. Favourable hydrogen bonds between ligand and NQO1, and parallel orientation between ligand and flavin adenine dinucleotide could explai...