Quiet but not silent: assessing the impact of intact and defective HIV proviral DNA in the brain [0.03%]
寂静而不沉默：评估完整和缺陷HIV原病毒DNA在脑中的影响
Emily K Chalmers,Janna Jamal Eddine,Liam Yucel et al.
Emily K Chalmers et al.
Purpose of review: People with HIV (PWH) require lifelong antiretroviral therapy (ART) to maintain viral suppression, yet integrated HIV DNA persists in long-lived cellular reservoirs in blood and tissues. Most integrated...
Melissa Churchill
Melissa Churchill
Heidi M Crane
Heidi M Crane
Thomas A Angelovich,Kathleen Busman-Sahay,Janna Jamal Eddine et al.
Thomas A Angelovich et al.
Purpose of review: Neurocognitive disorders and neuropathology continue to affect a subset of people with HIV (PWH) despite long-term viral suppression with antiretroviral therapy (ART). The mechanisms driving persistent ...
Glucagon-like peptide-1 receptor agonists in the aging population of people with HIV: emerging evidence and clinical implications [0.03%]
人胰高糖素样肽-1受体激动剂在HIV感染人群中应用的证据和临床意义——聚焦老年人群的影响
Lara Haidar,Joseph A C Delaney
Lara Haidar
Purpose of review: The increasing use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) for type 2 diabetes and obesity has generated interest in their potential role among people with HIV (PWH), who experience a hi...
Ekta Singh,Alan L Landay,Matthew L Mendoza
Ekta Singh
Purpose of review: People with HIV (PWH) on effective antiretroviral therapy continue to experience a disproportionate burden of age-related comorbidities and multimorbidity. This review explores HIV-associated aging as a...
Measuring neurocognitive impairment in virally suppressed HIV: HIV-associated neurocognitive disorders, HIV-associated brain injury problems and solutions [0.03%]
艾滋病病毒感染抑制患者的神经认知功能检测：艾滋病相关的神经认知障碍及其脑损伤问题与对策研究
Bruce J Brew,Lucette A Cysique
Bruce J Brew
Purpose of review: To discuss neurocognition measurement in view of current controversies in HIV-associated neurocognitive disorders (HAND). Recent findin...
Rogier W Sanders,Tom G Caniels,John P Moore et al.
Rogier W Sanders et al.
Purpose of review: It is standard practice to protect infants against viruses that they are exposed to early in life, during childhood, or as adults. While HIV-1 is only rarely a risk in the period between the end of brea...
Nanouk Zuidmeer,Jori Symons,Monique Nijhuis
Nanouk Zuidmeer
Purpose of the review: This review summarizes recent advances in understanding HIV infection of the brain, focusing on viral persistence in microglia and associated pathogenesis during viremia and viral suppression. We hi...