Thibaut Dagand,Julien Paul Gigan,Rémi Fromentin et al.
Thibaut Dagand et al.
Purpose of review: HIV persists despite effective antiretroviral therapy (ART) due to long-lived reservoirs that resist immune clearance. In people with HIV (PWH) on ART, most infected cells reside in tissues rather than ...
How nonhuman primate infant and mother-infant models can inform pediatric HIV-1 cure research [0.03%]
非人类灵长类动物婴儿及母子模型如何推动儿童HIV-1治愈研究
Claire-Maëlle Fovet,Nabila Seddiki
Claire-Maëlle Fovet
Purpose of review: An estimated 1.4 million children live with HIV-1, yet major gaps remain in understanding neonatal pathogenesis and curative strategies. Nonhuman primate (NHP) infant and mother-infant models provide a ...
HIV broadly neutralizing antibodies for children: implementation barriers in low-income settings [0.03%]
低收入地区为儿童实施艾滋病毒广谱中和抗体的障碍
Arantza Cobela-García,Alfredo Tagarro,Pablo Rojo
Arantza Cobela-García
Purpose of review: Broadly neutralizing monoclonal antibodies (bNAbs) represent a transformative frontier for the prevention, treatment, and potential remission of HIV in children. Given that over 95% of the pediatric pop...
Virological biomarkers of HIV remission in children: implications for pediatric cure strategies [0.03%]
儿童HIV缓解的病毒学生物标志物：对儿科治愈策略的意义
Kavidha Reddy,Thumbi Ndung&#x;u
Kavidha Reddy
Purpose of review: Sustained antiretroviral therapy (ART)-free HIV remission has been observed in a few early-treated children, highlighting the potential for pediatric HIV cure strategies. However, the risks associated w...
Claudia Melo,Jonathan S Lochner,Alberto Bosque
Claudia Melo
Purpose of review: Well tolerated, scalable strategies capable of targeting latent HIV reservoirs are essential for the development of cure approaches that can be implemented globally. In recent years, common γ-chain cyt...
What can spontaneous controllers, posttreatment controllers and postintervention controllers teach us about an HIV cure? [0.03%]
自发控制者、治疗控制者和干预控制者能教会我们怎样的HIV治愈方式？
Joel N Blankson
Joel N Blankson
Purpose of review: HIV controllers are a heterogenous population of people living with HIV who control viral replication without antiretroviral therapy. The purpose of this review is to summarize potential mechanisms of c...
Andrea Mastrangelo,Riddhima Banga,Matthieu Perreau
Andrea Mastrangelo
Purpose of review: The existence of HIV controllers offers the possibility of identifying specific immune-virological attributes associated with the control of HIV replication, possibly guiding the development of immunolo...
Novel attributes of HIV-1 elite controllers: redefining persistent HIV-1 remission [0.03%]
HIV-1精英控制者的新特征：重新定义持续的HIV-1缓解
Ezequiel Ruiz-Mateos
Ezequiel Ruiz-Mateos
Cristina Moral-Turón,María Antequera-Martínez,Ezequiel Ruiz-Mateos
Cristina Moral-Turón
Purpose of review: In this review, we intend to define the main characteristics of the elite controller reservoir, exploring into its heterogeneity, which goes hand in hand with the different progression phenotypes within...
Nicolas Noel,Olivier Lambotte
Nicolas Noel
Purpose of review: Achieving a functional cure for HIV remains a major challenge. In this context, elite controllers (ECs) - rare people living with HIV who maintain durable virological suppression without antiretroviral ...